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The generation of various subtypes of neurons and glial cells at the right time and place is crucial for the proper development
of the vertebrate CNS. Although the mechanisms and factors for the regulation of neuronal diversity in the CNS have been well
studied, the mechanisms regulating the sequential production of neuronal and glial cells from neural precursors remain poorly
understood. This study shows that Tcf3, a member of the Lef/Tcf family of proteins, is required to inhibit the premature oligodendroglial
fate specification of spinal cord precursors using the transgenic zebrafish, which expresses a dominant repressor form of
Tcf3 under the control of a heat-shock inducible promoter. In addition, the data revealed that Tcf3 function in oligodendroglial
fate specification is mediated independently of canonical Wnt signaling. Altogether, these results show a novel function for
Tcf3 in regulating the timing of oligodendroglial fate specification in the spinal cord. 相似文献
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Dee CT Hirst CS Shih YH Tripathi VB Patient RK Scotting PJ 《Developmental biology》2008,320(1):289-301
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Epigenetic control of neural stem cell fate 总被引:18,自引:0,他引:18
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《Fly》2013,7(6):316-319
In this “Extra View” article we highlight some of the recently accumulating evidence showing that Hox genes are involved at different steps during the development of neural cell lineages to control segmental patterning of the CNS. In addition to their well-known early role in establishing segmental identities, Hox genes act on neural stem cells and their progeny at various stages during embryonic and postembryonic development to control proliferation, cell fate and/or apoptosis in a segment-specific manner. This leads to differential shaping of serially homologous lineages and thus to structural diversification of segmental CNS units (neuromeres) in adaptation to their specific functional tasks in processing sensory information and generation of motor patterns. 相似文献
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Matter-Sadzinski L Matter JM Ong MT Hernandez J Ballivet M 《Development (Cambridge, England)》2001,128(2):217-231
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Human Mesenchymal Stem Cells Signals Regulate Neural Stem Cell Fate 总被引:12,自引:0,他引:12
Neural stem cells (NSCs) differentiate into neurons, astrocytes and oligodendrocytes depending on their location within the
central nervous system (CNS). The cellular and molecular cues mediating end-stage cell fate choices are not completely understood.
The retention of multipotent NSCs in the adult CNS raises the possibility that selective recruitment of their progeny to specific
lineages may facilitate repair in a spectrum of neuropathological conditions. Previous studies suggest that adult human bone
marrow derived mesenchymal stem cells (hMSCs) improve functional outcome after a wide range of CNS insults, probably through
their trophic influence. In the context of such trophic activity, here we demonstrate that hMSCs in culture provide humoral
signals that selectively promote the genesis of neurons and oligodendrocytes from NSCs. Cell–cell contacts were less effective
and the proportion of hMSCs that could be induced to express neural characteristics was very small. We propose that the selective
promotion of neuronal and oligodendroglial fates in neural stem cell progeny is responsible for the ability of MSCs to enhance
recovery after a wide range of CNS injuries.
Special issue dedicated to Anthony Campagnoni. 相似文献