Policies and Programmatic Efforts Pertaining to Fatherhood: Commentary

The articles in this section focus attention on (1) the historical shift in policies that affect the young men of this nation (2) how fatherhood policies and programmatic efforts are expanding and (3) how fatherhood practices and policies could and perhaps should be expanded and elaborated further. These efforts are linked to a growing body of research documenting the importance of fathers in children's lives, summarized in other sections of this issue. In our commentary we review the changing policy and programmatic climate with regards to fathers and note the opportunities for the policy and programmatic worlds for the future and for policy and programmatic research to move to new levels in enhancing the knowledge base.     

Comments on Cabrera,Fitzgerald, Roggman,and Bradley: "Modeling the Dynamics of Paternal Influences on Children Over the Life Course"

This commentary on "Modeling the Dynamics of Paternal Influences on Children over the Life Course" briefly focuses on issues of universality, idealized fatherhood, developmental understanding of fatherhood, and measurement. It is suggested that expanding on these issues will strengthen the model's scope and broad applicability.     

Commentary: Impact of Father Involvement on Children's Developmental Trajectories: New Findings Panel for the National Fatherhood Forum

Numerous scholars have called for increased attention to, and sophistication in, understanding the family roles of fathers and their influence on children's development. The articles in this section provide notable moves forward in several arenas, focusing on traditionally understudied populations of fathers, employing a variety of data collection methodologies, and assessing leading theoretical models in the field. In this commentary, the authors review these strengths and delineate important next steps for fathering research. They call for increased research in three arenas: (1) attention to fathers' uniqueness through detailed study of the similarities and differences in mothers' and fathers' behaviors and effects on children; (2) a focus on generalizability, developing models and methods that can be applied across diverse samples of fathers; and (3) more rigorous development and assessment of models delineating fathers' influence on children's development, attending to both promotive and harmful effects of fathering.     

Making Fathers Count: Methodological Dilemmas and Emerging Solutions

This commentary reviews recent methodological approaches to empirical investigations of hard-to-reach fathers. It suggests that the growing heterogeneity of fatherhood needs to be matched by a more flexible methodological tool-kit.     

Is communication improving between general practitioners and psychiatrists?

General practitioners and psychiatrists communicate mainly by letter. To ascertain the most important items of information that should be included in these letters ("key items") questionnaires were sent to 80 general practitioners and 80 psychiatrists. A total of 120 referral letters sent to psychiatric clinics in 1973 and 1983 were studied, together with the psychiatrists'' replies, and these were rated for the inclusion of "key items." General practitioners'' letters contain less information about the family but more about psychiatric history than they did a decade ago. Overall, psychiatrists'' letters have not changed. Registrars, however, now include noticeably more "key items" than they did 10 years ago, but their letters remain twice the length of those written by consultants. It is suggested that letter writing skills are vital to good patient management and should be taught to postgraduate trainees in general practice and psychiatry.     

The prevention and eradication of smallpox: a commentary on Sloane (1755) ‘An account of inoculation’

Sir Hans Sloane''s account of inoculation as a means to protect against smallpox followed several earlier articles published in Philosophical Transactions on this procedure. Inoculation (also called ‘variolation’) involved the introduction of small amounts of infectious material from smallpox vesicles into the skin of healthy subjects, with the goal of inducing mild symptoms that would result in protection against the more severe naturally acquired disease. It began to be practised in England in 1721 thanks to the efforts of Lady Mary Wortley Montagu who influenced Sloane to promote its use, including the inoculation of the royal family''s children. When Edward Jenner''s inoculation with the cow pox (‘vaccination’) followed 75 years later as a safer yet equally effective procedure, the scene was set for the eventual control of smallpox epidemics culminating in the worldwide eradication of smallpox in 1977, officially proclaimed by WHO in 1980. Here, we discuss the significance of variolation and vaccination with respect to scientific, public health and ethical controversies concerning these ‘weapons of mass protection’. This commentary was written to celebrate the 350th anniversary of the journal Philosophical Transactions of the Royal Society.     

When ‘blood speaks’: naming the father and the mystics of kinship in Dominica,Eastern Caribbean

This article explores the mystical implication of fathers in reproduction in Dominica, Eastern Caribbean. It traces naming acts that assign paternity at various points in the filial life course, each attempting to disambiguate paternity. Confronting a recurring anthropological problematic – the problem of paternity (paternity's inherent putativity) – the article argues that Dominicans contest uncertain physical fatherhood through the proverb ‘blood speaks’. The article elaborates how relatedness reveals itself in the subtle bodies of kin at three moments: through a local version of the couvade (‘sympathetic pregnancy’); in elders’ post-partum ritual scrutiny of children's bodies for familial resemblances; and during serendipitous encounters in later life. The article highlights how physical fatherhood is disclosed in fathers’ and children's symptoms, appearances, and sensations, revealing their kinship in transpersonal terms. Therefore, blood ‘speaks’ to counter broad-brushed narratives of Caribbean fatherly absence by revealing the physical and spiritual significance of fatherhood. Herein, the article revives classic anthropological debates on legitimacy, the couvade, and Caribbean kinship, whilst contributing to contemporary theorizations of blood and naming.     

人组织激肽释放酶4在激素依赖性肿瘤中的研究进展

人组织激肽释放酶基因家族由KLK1-KLK15构成,编码一组丝氨酸蛋白酶。研究发现KLK基因家族涉及癌细胞的多种生物学功能,且其表达受类固醇激素的调节。人组织激肽释放酶4是丝氨酸蛋白酶家族的一个成员,在多种激素依赖性肿瘤如卵巢癌、前列腺癌、乳腺癌、子宫内膜癌中高表达,且表达量受雌激素、孕激素、雄激素不同程度的调节。近年来很多文献报道人组织激肽释放酶4涉及癌细胞的增殖、上皮间质转化及细胞外基质的降解等过程,可能促进了肿瘤的发生、发展,且与激素依赖性肿瘤的预后不良有关。这些研究显示人组织激肽释放酶4与激素依赖性肿瘤关系密切,是其潜在的肿瘤标记物和治疗靶点,随着研究的进一步深入,有望应用于激素依赖性肿瘤的早期诊断、病程监测和治疗。     

Palliative care: views of patients and their families.

OBJECTIVE--To investigate the current problems and needs of terminally ill cancer patients and their family members, and to discover their views of hospital, community, and support team services. DESIGN--Prospective study of patients and families by questionnaire interviews in the patients'' homes. SETTING--Inner London and north Kent (London suburbs). SUBJECTS--65 Patients, each with a member of their family or a career. MAIN OUTCOME MEASURES--Ratings of eight current problems and ratings and comments on three services-hospital doctors and nurses, general practitioners and district nurses, and the support team staff-obtained after a minimum of two weeks'' care from palliative care support teams. RESULTS--Effect of anxiety on the patient''s nearest career. and symptom control were rated as the most severe current problems by both patients and families; a few patients and families identified other severe problems. Families'' ratings of pain control, symptom control, and effect of anxiety on the patient were significantly worse than the patients'' ratings (p less than 0.05). Support teams received the most praise, being rated by 58 (89%) patients and 59 (91%) of family members as good as excellent. General practitioners and district nurses were rated good or excellent by 46 (71%) patients and 46 (71%) family members, but six (9%) in each group rated the service as poor or very bad, and ratings in the inner London district were significantly worse than those in the outer London district. Hospital doctors and nurses were rated good or excellent by 22 (34%) patients and 35 (54%) of family members, and 14 (22%) patients and 15 (23%) family members rated this service as poor or very bad. Negative comments referred to communication (especially at diagnosis), coordination of services, the attitude of the doctor, delays in diagnosis, and difficulties in getting doctors to visit at home. Family members were more satisfied with the services than were patients. CONCLUSIONS--Palliative care needs to include both the patient and family because the needs of the family may exceed those of the patient. Support teams and some hospital and community doctors and nurses met the perceived needs of dying patients and families, but better education and organisation of services are needed.     

Monitoring equilibrium changes in RNA structure by 'peroxidative' and 'oxidative' hydroxyl radical footprinting

RNA molecules play an essential role in biology. In addition to transmitting genetic information, RNA can fold into unique tertiary structures fulfilling a specific biologic role as regulator, binder or catalyst. Information about tertiary contact formation is essential to understand the function of RNA molecules. Hydroxyl radicals (•OH) are unique probes of the structure of nucleic acids due to their high reactivity and small size.¹ When used as a footprinting probe, hydroxyl radicals map the solvent accessible surface of the phosphodiester backbone of DNA¹ and RNA² with as fine as single nucleotide resolution. Hydroxyl radical footprinting can be used to identify the nucleotides within an intermolecular contact surface, e.g. in DNA-protein¹ and RNA-protein complexes. Equilibrium³ and kinetic⁴ transitions can be determined by conducting hydroxyl radical footprinting as a function of a solution variable or time, respectively. A key feature of footprinting is that limited exposure to the probe (e.g., ''single-hit kinetics'') results in the uniform sampling of each nucleotide of the polymer.⁵In this video article, we use the P4-P6 domain of the Tetrahymena ribozyme to illustrate RNA sample preparation and the determination of a Mg(II)-mediated folding isotherms. We describe the use of the well known hydroxyl radical footprinting protocol that requires H₂O₂ (we call this the ''peroxidative'' protocol) and a valuable, but not widely known, alternative that uses naturally dissolved O₂ (we call this the ''oxidative'' protocol). An overview of the data reduction, transformation and analysis procedures is presented.Download video file.^{(82M, mov)}     

Identifying Targets of Human microRNAs with the LightSwitch Luciferase Assay System using 3'UTR-reporter Constructs and a microRNA Mimic in Adherent Cells

MicroRNAs (miRNAs) are important regulators of gene expression and play a role in many biological processes. More than 700 human miRNAs have been identified so far with each having up to hundreds of unique target mRNAs. Computational tools, expression and proteomics assays, and chromatin-immunoprecipitation-based techniques provide important clues for identifying mRNAs that are direct targets of a particular miRNA. In addition, 3''UTR-reporter assays have become an important component of thorough miRNA target studies because they provide functional evidence for and quantitate the effects of specific miRNA-3''UTR interactions in a cell-based system. To enable more researchers to leverage 3''UTR-reporter assays and to support the scale-up of such assays to high-throughput levels, we have created a genome-wide collection of human 3''UTR luciferase reporters in the highly-optimized LightSwitch Luciferase Assay System. The system also includes synthetic miRNA target reporter constructs for use as positive controls, various endogenous 3''UTR reporter constructs, and a series of standardized experimental protocols.Here we describe a method for co-transfection of individual 3''UTR-reporter constructs along with a miRNA mimic that is efficient, reproducible, and amenable to high-throughput analysis.Download video file.^{(45M, mov)}     

Avoiding risk at what cost? Putting use of medicines for breastfeeding women into perspective

Breastfeeding women often need to take medicines, and therefore health professionals need to consider the effects of medication on lactation and the breastfed infant, and any associated risks. This commentary discusses the tragic case of a young woman with a history of mental illness who committed suicide in the postpartum period. She was determined to be a 'good mother' and breastfeed, and to avoid any potential adverse effects of medication on her breastfed infant. The final outcome was fatal for both mother and child. We argue that if women require medication during lactation, all risks need to be considered ?C the risk of not treating the maternal medical condition may greatly outweigh the potential risk to the breastfed infant.     

The psychological and social effects of myocardial infarction on wives.

Eighty-two wives of men suffering a first myocardial infarction were interviewed while their husbands were in hospital, and again two months and a year after they went home. The wives had substantial and persistent psychological symptoms, and the husbands'' illness had continuing effects on their work, leisure and social activities, and family life and marriage, their psychosocial disability being comparable to that of the patients. Measures of psychosocial adjustment before the illness and the quality of the marriage and of family life were good predictors of outcome for the wives. The women had a major role in the patients'' readjustment during convalescence, and their attitudes and behaviour as well as the general quality of family life were important determinants of the rate and extent of the patients'' recovery. The wives of patients with myocardial infarction should have more practical help and advice during the hospital period, and the whole family should be given advice and help throughout the convalescence.     

Fathers and Public Policy

Until recently, policy makers viewed fathers' provision of child support as the most policy-relevant form of father involvement. In contrast, other policy initiatives have not been as widely explored. This article identifies current fatherhood policies and considers the mixed implications of these policy and practice interventions for father involvement and child well-being. We conclude with suggestions for future fatherhood policies and initiatives.     

重点生态功能区农户对生态系统服务的感知——以甘南高原为例

农户作为重点生态功能区的主要经济活动主体,其对生态系统服务的感知直接影响着环境行为,这不仅关系到生态保护计划的执行效果,更关系到该区主体功能的发挥。以地处青藏高原东缘的甘南高原为例,基于入户调查数据,分析了农户对草地、森林、湿地、农田生态系统服务的感知,并运用多元线性回归模型分析了影响农户生态系统服务感知的关键因素。结果表明:(1)甘南高原农户对森林、草地、农田、湿地生态系统服务的多样化感知依次减弱,其中,半农半牧区农户对各类生态系统服务的多样化感知强于农牧区;(2)农户对森林、草地、农田、湿地生态系统服务重要性、可管理性、脆弱性、损害度的感知度依次降低,且不同区域农户的属性感知存在差异;(3)个体特征、家庭特征是影响农户生态系统服务多样化感知的重要因素,个体特征、家庭特征、环境政策是影响农户生态系统服务属性感知的重要因素。     

沙化土地封禁保护政策的农户满意度及影响因素分析——以甘肃省为例

农户是生态治理政策的"践行者",也是政策效果的"检验者",其满意度对政策的可持续实施至关重要。基于甘肃省沙化土地封禁保护区周边1417份农户调查数据,运用帕累托分析方法和Ordered Logit模型,就沙化土地封禁保护政策的农户满意度及影响因素展开分析。研究结果表明:沙化土地封禁保护政策的农户总体满意度介于"一般"和"满意"之间,均值为3.67("非常满意"为5);外部影响因素分析表明,政策实施效果中风沙危害削减程度、荒漠化逆转程度、家庭收入提升状况、破坏行为减少程度与农户满意度之间存在正相关性;生态变化感知中的风沙强度、水资源紧缺程度对农户满意度起负向作用,降雨(雪)次数变化、荒漠植被盖度对农户满意度起正向作用。农户内部自身因素中,家庭人均收入、耕地、政府补贴、性别、教育程度、健康状况与农户满意度均通过显著性检验。控制变量因素中地方政府治理重视程度与农户满意度呈正相关性,平原地区的农户满意度明显高于山区。从政策角度看,农户生计改善是未来沙化土地封禁保护政策成功实施的关键保障。     

Meeting Report on the Conference on Fathers’ Role in Children’s Weight‐Related Behaviors and Outcomes

On September 22, 2017, “Engaging the Forgotten Parent: Conference of Experts on Fathers’ Role in Children’s Weight‐Related Behaviours and Outcomes” brought researchers, students, health professionals, community stakeholders, and knowledge users from Canada, Australia, and the United States together to Toronto, Ontario, for a 1‐day gathering focused on furthering scientific understanding of effective strategies to recruit, engage, and retain fathers in family‐based obesity research. Furthermore this conference focused on identifying key knowledge gaps and opportunities for collaborative research to further our understanding of fathers’ roles in the development of their children’s behaviors and weight outcomes. The following four themes emerged from the conference: (1) underrepresentation of fathers in family‐based obesity research, (2) fathers’ engagement in children’s weight‐related behaviors and desire to participate in research, (3) best practices in recruiting, engaging, and retaining fathers in research, and (4) key lessons learned from fatherhood research in developmental science.     

Challenges and opportunities of publishing supplements at <Emphasis Type="Italic">Arthritis Research &; Therapy</Emphasis>

Supplements are the cause of much debate in the world of journal publishing. Supplements are criticized for the fact that often they are funded by an external source, and journals have been known to shy away from their publication [1]. But is refusing to publish supplements the only answer? At Arthritis Research & Therapy, we feel that - if subjected to the full rigors of peer review - supplements can provide invaluable educational resources, exploring themes in a detailed and focused way that might not always be possible in the main journal.At Arthritis Research & Therapy, we have decided that the potential risk of a loss of objectivity in industry-sponsored supplements can be managed by scrupulous attention to the peer-review process. Therefore, in our experience, the benefit of publishing supplements greatly outweighs any perception of loss of objectivity. We should note that our colleagues in the pharmaceutical industry have embraced our approach with no efforts to circumvent our rules, as far as we know.We consider proceedings, review collections, and meeting abstracts for inclusion as supplements. Examples of recent supplements are easily accessed on the journal website. It will be apparent that the emphasis is on the molecular and cellular basis of immune and inflammatory mechanisms of disease. The underwriting by the sponsor of the cost of peer review and production ensures that the high-quality publication is freely available. Outlined below is the procedure that we follow when considering any potential supplements for the journal. We recognize the potential for competing interests to influence the content of articles where there is industry involvement, but we believe that by adhering to a stringent publication process we negate this risk with our supplement content.So, what is the procedure? First, in a change from the approach taken by many journals, we appoint an ''internal'' Supplement Editor (usually from the journal''s Editorial Board), whose role is to select peer reviewers and assess the suitability of the supplement articles for publication in the journal. This internal editor is selected by the Editors-in-Chief, and the sponsor''s approval is not sought in making this appointment. Before their appointment, internal editors are asked to declare any potential conflicts of interest, and full disclosures are included in both online and print versions of any supplements. In cases in which internal editors receive a stipend, this is paid for by the publisher - not the sponsor. All conflict of interest disclosures associated with supplement publications follow the National Library of Medicine policy for indexing supplement articles in MEDLINE [2].For some supplements, particularly where articles are commissioned externally, there may be an ''external'' Supplement Editor as well as the internal editor. Before their appointment, external supplement editors must be approved by the Editors-in-Chief. Their role is to identify the subject matter and propose suitable authors for the individual supplement articles, with the proviso that all content must be approved by the Editors-in-Chief. The external editor is not involved in the peer review of any of the articles once submitted. They are also asked for full conflict of interest disclosures, which are included in the supplement publication alongside those of the internal editor.One of the common criticisms levied against supplements is that the articles are not peer-reviewed to the journal''s normal standards. At Arthritis Research & Therapy, supplement articles go through the same thorough peer-review process as articles do in the main journal [3]. The Editors-in-Chief have full editorial control, including the ability to ask authors to make extensive revisions, and reserve the right to reject articles that do not meet the journal''s standards. And in accordance with the guidelines of the International Committee for Medical Journal Editors [4], all contracts clearly include information about editorial control and the role of the internal supplement editor.In addition to disclosures from the individual editors, sources of funding for a supplement are prominently displayed on the supplement title page, and funding is also acknowledged in each individual article. We ensure that supplements can be clearly distinguished as separate from the main journal content on the journal homepage. As with all of our articles, individual authors declare their conflicts of interest. This complies with the good publication practice (GPP2) guidelines [5]. We also adhere to the guidelines of the European Medical Writers Association [6] by ensuring that the involvement of any medical writers is disclosed in an article''s acknowledgments section along with their sources of funding.We hope that by ensuring that there is full transparency of disclosures from everyone involved in supplements and following strictly the peer-review procedure described above, we avoid the potential pitfalls of supplement publishing. The guidelines of the International Committee of Medical Journal Editors themselves state that supplements ''serve useful purposes'' and it is our responsibility as editors to ensure that they continue to be useful without allowing ourselves to be subject to industry influence. By publicly disclosing our policy for supplement review here, we hope that other journals will be more open about their peer-review policies for supplements and that they adopt similarly stringent practices in the future.     

Complexities in Research on Fathering: Illustrations from the Tufts Study of Young Fathers

Theory and research suggest that the transition to parenthood is a major life transition, and that adaptation to the parenting role is influenced by a complex set of factors, including the relationship with the child's mother, family of origin, and how the father is situated within sociocultural contexts. The father–]mother relationship is particularly important for men making the transition to fatherhood. This study examined patterns of fathering among young fathers (15–24 years) and investigated how fathers' relationships with the mothers of their young children (infants and toddlers) were related to fathering. In general, higher quality father–mother relationships were related to greater father involvement with children; when mothers were perceived as barriers to involved fathering fathers also had less accurate and adaptive parenting knowledge, attitudes, and behavior. Person-centered analyses revealed quite complex relations between father–mother relationships and father–child interaction. One pattern showed strong positive father–mother relationships associated with a disengaged pattern of father–child interaction, while another pattern showed sensitive and positive father–child engagement in the context of negative or distant father–mother relationships. Four patterns of association between fathering and mother–father relationships were demonstrated. Results highlight the complexity of understanding fathering and family relationships among young fathers.