Plasticity‐led evolution: A survey of developmental mechanisms and empirical tests

Recent years have witnessed increased interest in evaluating whether phenotypic plasticity can precede, facilitate, and possibly even bias adaptive evolution. Despite accumulating evidence for “plasticity‐led evolution” (i.e., “PLE”), critical gaps remain, such as: how different developmental mechanisms influence PLE; whether some types of traits and taxa are especially prone to experience PLE; and what studies are needed to drive the field forward. Here, we begin to address these shortcomings by first speculating about how various features of development—modularity, flexible regulation, and exploratory mechanisms—might impact and/or bias whether and how PLE unfolds. We then review and categorize the traits and taxa used to investigate PLE. We do so both to identify systems that may be well‐suited for studying developmental mechanisms in a PLE context and to highlight any mismatches between PLE theory and existing empirical tests of this theory. We conclude by providing additional suggestions for future research. Our overarching goal is to stimulate additional work on PLE and thereby evaluate plasticity's role in evolution.     

Social is Emotional

This is a biological approach to the philosophy of mind that feeds an investigation of the phenomena of “social” and “emotional”, both of which are widespread in nature. I scrutinize the non-dualistic Darwinian concept of the continuity of mind. For practical reasons, I address mind at different levels of organization: The systemic mind are the properties of which a common, coherent evolution works upon. Separated from this is “language-mind”: the crystallization of thought in words, which is a strictly human phenomenon. As the phenomenology of the body is a theory of philosophy that lie beyond language it can—to a certain extent—be extrapolated across a species boundary. In the process the phenomenology of the body comes to resemble biosemiotics and with this tool, I investigate a field study of social play behavior in canids. This leads to a possibility to study the non-human experience of emotion as “locally meaningful phenomena”.     

Mesenchymal stromal cell therapy for coronavirus disease 2019: which? when? and how much?

Mesenchymal stromal cells (MSCs) are under active consideration as a treatment strategy for controlling the hyper-inflammation and slow disease progression associated with coronavirus disease 2019 (COVID-19). The possible mechanism of protection through their immunoregulatory and paracrine action has been reviewed extensively. However, the importance of process control in achieving consistent cell quality, maximum safety and efficacy—for which the three key questions are which, when and how much—remains unaddressed. Any commonality, if it exists, in ongoing clinical trials has yet to be analyzed and reviewed. In this review, the authors have therefore compiled study design data from ongoing clinical trials to address the key questions of “which” with regard to tissue source, donor profile, isolation technique, culture conditions, long-term culture and cryopreservation of MSCs; “when” with regard to defining the transplantation window by identifying and staging patients based on their pro-inflammatory profile; and “how much” with regard to the number of cells in a single administration, number of doses and route of transplantation. To homogenize MSC therapy for COVID-19 on a global scale and to make it readily available in large numbers, a shared understanding and uniform agreement with respect to these fundamental issues are essential.     

The interpretation of selection coefficients

Evolutionary biologists have an array of powerful theoretical techniques that can accurately predict changes in the genetic composition of populations. Changes in gene frequencies and genetic associations between loci can be tracked as they respond to a wide variety of evolutionary forces. However, it is often less clear how to decompose these various forces into components that accurately reflect the underlying biology. Here, we present several issues that arise in the definition and interpretation of selection and selection coefficients, focusing on insights gained through the examination of selection coefficients in multilocus notation. Using this notation, we discuss how its flexibility—which allows different biological units to be identified as targets of selection—is reflected in the interpretation of the coefficients that the notation generates. In many situations, it can be difficult to agree on whether loci can be considered to be under “direct” versus “indirect” selection, or to quantify this selection. We present arguments for what the terms direct and indirect selection might best encompass, considering a range of issues, from viability and sexual selection to kin selection. We show how multilocus notation can discriminate between direct and indirect selection, and describe when it can do so.     

The Semiglades: The Collision of Restoration,Social Values,and the Ecosystem Concept

Defining success targets in restoration and how social values affect them are two commonly discussed issues in restoration today. We believe that how success is commonly defined—with vague terms such as “healthy ecosystem” or cited as a return to a previous, historic state—needs to be reevaluated. With the increasing number of novel ecosystems, there is an increasing conflict between the ecosystem concept, social values, and restoration. This arises from the fact that ecosystems are defined by the values of the scientists describing them, necessarily constraining the ecosystem to a generally static concept. It is not directly the concept, but how it is perceived through our filter of social values that represses the creativity and innovation needed in restoration today. Within restoration, we feel that the ecosystem concept does a disservice by ignoring the increasing number of novel systems, and that hinders real progress in a time when hesitation can be costly. To best illustrate this, we offer the example of restoration of the Florida Everglades and how it has become a novel system in pattern and process. We suggest renaming the Everglades “The Semiglades” in hopes of opening a dialog to expose social/ecosystem biases and include novel landscapes in management and planning.     

Three sensible paradigms for research on evolution and human behavior?

Far from being involved in a fundamental division, the study of evolution and human behavior is fortunate to have three potentially productive paradigms which could usefully coexist. In so far as “Darwinian psychology” (DP) is the study of causal mechanisms, guided by thinking about the tasks the mechanisms must perform, it has a clear place alongside the study of adaptedness. Instead of arguing its right to exist by pointing out problems with “adaptationism,” DP should present its audience with more examples of how DP research can be conducted. Meanwhile, adaptationists might move on from asking whether people behave as if they are maximizing fitness, and decide what to do with their finding that the answer is often “yes.” They might also get actively involved with dual inheritance theory, developing ways to make it yield more predictions.     

Invasion ecology goes to town: from disdain to sympathy

How can one understand the increasing interest in “urban invasions”, or biological invasions in urban environments? We argue that interest in urban invasions echoes a broader evolution in how ecologists view “the city” in relation to “the natural”. Previously stark categorical distinctions between urban and natural, human and wild, city and ecology have floundered. Drawing on conceptual material and an analysis of key texts, we first show how the ecological sciences in general—and then invasion science in particular—previously had a blind spot for cities, despite a number of important historical and continental European exceptions. Then, we document the advent of an urban turn in ecology and, more recently, in invasion ecology, and how this has challenged fundamental concepts about “nativity”, “naturalness”, and human agency in nature. The urban turn necessitates more explicit and direct attention to human roles and judgements. Ecology has moved from contempt (or indifference) for cities, towards interest or even sympathy.     

Medical Humanitarianism Under Atmospheric Violence: Health Professionals in the 2013 Gezi Protests in Turkey

During the 2013 Gezi protests in Turkey, volunteering health professionals provided on-site medical assistance to protesters faced with police violence characterized by the extensive use of riot control agents. This led to a government crackdown on the medical community and the criminalization of “unauthorized” first aid amidst international criticisms over violations of medical neutrality. Drawing from ethnographic observations, in-depth interviews with health care professionals, and archival research, this article ethnographically analyzes the polarized encounter between the Turkish government and medical professionals aligned with social protest. I demonstrate how the context of “atmospheric violence”—the extensive use of riot control agents like tear gas—brings about new politico-ethical spaces and dilemmas for healthcare professionals. I then analyze how Turkish health professionals framed their provision of health services to protestors in the language of medical humanitarianism, and how the state dismissed their claims to humanitarian neutrality by criminalizing emergency care. Exploring the vexed role that health workers and medical organizations played in the Gezi protests and the consequent political contestations over doctors’ ethical, professional, and political responsibilities, this article examines challenges to medical humanitarianism and neutrality at times of social protest in and beyond the Middle East.     

Extending Ethnoprimatology: Human–Alloprimate Relationships in Managed Settings

The majority of studies in ethnoprimatology focus on areas of sympatry where humans and nonhuman primates (hereafter, primates) naturally coexist. We argue that much can be gained by extending the field’s scope to incorporate settings where humans manage most aspects of primates’ lives, such as zoos, laboratories, sanctuaries, and rehabilitation centers (hereafter, managed settings). We suggest that the mixed-methods approach of ethnoprimatology, which facilitates examination of both humans’ and primates’ responses to one another, can reveal not only how humans’ ideas about primates shape management strategies, but also how those management strategies affect primates’ lives. Furthermore, we note that a greater focus on managed settings will strengthen links between ethnoprimatology and primate rights/welfare approaches, and will introduce new questions into discussions of ethics in primatology. For example, managed settings raise questions about when it might be justifiable to restrict primates’ freedom for a “greater good,” and the desirability of making primates’ lives more “natural” even if this would decrease their well-being. Finally, we propose that because ethnoprimatology is premised on challenging false dichotomies between categories of field site—specifically, between “natural” and “unnatural” free-ranging populations—it makes sense for ethnoprimatologists to examine settings in which humans exert considerable control over primates’ lives, given that the distinction between “wild” and “captive” is similarly unclear.     

Regulation of obesity and insulin resistance by nitric oxide

Obesity is a risk factor for developing type 2 diabetes and cardiovascular disease and has quickly become a worldwide pandemic with few tangible and safe treatment options. Although it is generally accepted that the primary cause of obesity is energy imbalance, i.e., the calories consumed are greater than are utilized, understanding how caloric balance is regulated has proven a challenge. Many “distal” causes of obesity, such as the structural environment, occupation, and social influences, are exceedingly difficult to change or manipulate. Hence, molecular processes and pathways more proximal to the origins of obesity—those that directly regulate energy metabolism or caloric intake—seem to be more feasible targets for therapy. In particular, nitric oxide (NO) is emerging as a central regulator of energy metabolism and body composition. NO bioavailability is decreased in animal models of diet-induced obesity and in obese and insulin-resistant patients, and increasing NO output has remarkable effects on obesity and insulin resistance. This review discusses the role of NO in regulating adiposity and insulin sensitivity and places its modes of action into context with the known causes and consequences of metabolic disease.     

The Two Faces of Social Interaction Reward in Animal Models of Drug Dependence

Drug dependence is a serious health and social problem. Social factors can modify vulnerability to developing drug dependence, acting as risk factors or protective factors. Whereas stress and peer environment that encourage substance use may increase drug taking, strong attachments between family members and peer environment that do not experience drug use may protect against drug taking and, ultimately, drug dependence. The rewarding effects of drug abuse and social interaction can be evaluated using animal models. In this review we focus on evaluating social interaction reward in the conditioned place preference paradigm. We give an overview of how social interaction, if made available within the drug context, may facilitate, promote and interact with the drug’s effects. However, social interaction, if offered alternatively outside the drug context, may have pronounced protective effects against drug abuse and relapse. We also address the importance of the weight difference parameter between the social partners in determining the positive or “agonistic” versus the hostile or “antagonistic” social interaction. We conclude that understanding social interaction reward and its subsequent effects on drug reward is sorely needed for therapeutic interventions against drug dependence.     

The business perspective in ecological restoration: issues and challenges

Much of the practice of restoration is conducted by businesses—contractors, consultants, designers, engineers. Restoration businesses interact with a variety of stakeholders to complete projects on time and on budget, and to achieve ecological and business objectives. Our research explores the business perspective in restoration; it is based on data collected from businesses (contractors, consultants, design engineers), agencies, and nongovernmental organizations involved in a Superfund cleanup project in Montana, one of the largest river restoration efforts ever. Our findings highlight several areas restoration businesses must navigate. First, restoration businesses must juggle potentially competing goals, maintaining ecological integrity while achieving profitability objectives. Second, these businesses must manage the risk that arises from variability in the natural environment as well as individuals' risk tolerances. Third, they must navigate the disconnect between “science” and “practice,” including how to best monitor restoration projects. Fourth, they must make decisions about new techniques and innovations. Fifth, on‐the‐ground implementation must acknowledge that personnels' motives and expertise might conflict with original plans. We discuss these findings in relation to relevant scholarly research, offering implications for theory and practice. For example, the business of ecological restoration requires learning over time to be profitable while achieving the desired ecological and social outcomes; restoration businesses leverage monitoring in pursuit of adaptive management and engage “frontline personnel” as important voices in the restoration process. Understanding the business of restoration adds an important perspective in the complex dynamics of social‐ecological systems.     

Fecal microbiota transplants: emerging social representations in the English-language print media

This study investigates how English-language news sources have represented fecal microbiota transplants (FMT). FMT involves transferring stool from a healthy donor to a recipient with a dysfunctional intestinal flora in order to repopulate their gut microbiome. FMT applications are increasingly moving into mainstream clinical care. We investigate press coverage of stool transplants, as well as broader themes associated with health and the gut microbiome, in order to uncover emerging social representations. Our findings show that print media focused in particular on creating novel, mainly hopeful, social representations of feces through wordplay and punning, side-lining issues of risk and fear. We also identify changing metaphorical framings of microbes and bacteria from “enemies” to “friends”, and ways in which readers are familiarized with FMT through the depiction of the process as both mundane and highly medicalized.     

Synthetic biology, patenting, health and global justice

The legal and moral issues that synthetic biology (SB) and its medical applications are likely to raise with regard to intellectual property (IP) and patenting are best approached through the lens of a theoretical framework highlighting the “co-construction” or “co-evolution” of patent law and technology. The current situation is characterized by a major contest between the so-called IP frame and the access-to-knowledge frame. In SB this contest is found in the contrasting approaches of Craig Venter’s chassis school and the BioBricks school. The stakes in this contest are high as issues of global health and global justice are implied. Patents are not simply to be seen as neutral incentives, but must also be judged on their effects for access to essential medicines, a more balanced pattern of innovation and the widest possible social participation in innovative activity. We need moral imagination to design new institutional systems and new ways of practising SB that meet the new demands of global justice.     

No water for the poor: the Roma ethnic minority and local governance in Slovakia

This article contributes to the emerging critiques of inequalities in the access to water by focusing on three inter-related aspects: affordability, accessibility and quality of water. Based on extensive fieldwork, the paper explores the situation in segregated Roma settlements in Slovakia and highlights the critical role of power asymmetries at a local level. It builds a conceptual framework using Bourdieu’s notions of “social field”, “habitus”, “doxa”, and “capital”, highlighting the central role of power asymmetries at a local level. Insights are drawn on how dominantly positioned social actors command decision-making regarding water supply, and how social hierarchies, inequalities and the “positionality” of Roma as a marginalized group are functional to the lack of political will to address insufficient water access for Roma in any efficient manner.     

What,if anything,is a social niche?

The term “social niche” is rapidly increasing in usage, particularly in the context of “social niche construction.” But what (if anything) is a social niche? Here, we survey papers that have used the term to uncover commonalities and discrepancies in its definition. We aim to alert researchers to the need for more consistency in how the term is used in the literature, and we provide a working definition of “social niche:” the set of social environments in which the focal individual has non-zero inclusive fitness. We consider the extent to which a social niche is analogous to an ecological niche, discuss whether a population-level social niche can be meaningfully identified, and describe conceptual insights about the properties of social niches, focusing on social niche construction. We highlight questions about social niches that demand more theoretical and empirical attention.     

The scanning behavior of juncos: A game-theoretical approach

Flocking birds frequently look up or “scan” while they are feeding on the ground. High scanning rates increase the probability that the birds in a flock will see an approaching predator in time to avoid predation; however, high scanning rates also decrease the feeding rates of the scanning individuals. Since the scanning rate that maximizes the survival probability of one individual depends on how frequently other birds in the same flock are scanning, the optimal scanning behavior must be modeled as a game. We develop a realistic model of scanning behavior and use it to find two game theoretical solutions—the “co-operative” or Pareto optimum and the “selfish” or Nash optimum. The observed scanning rates do not differ significantly from the co-operative optimal scanning rate. We argue that in a game where players meet again and again such apparent co-operation may be an evolutionarily stable strategy.     

Untamed <Emphasis Type="Italic">Jianghu</Emphasis> or Emerging Profession: Diagnosing the Psycho-Boom amid China’s Mental Health Legislation

This article focuses on the psychotherapy debate in China that was triggered by the country’s mental health legislation. Seeing the release of the draft Mental Health Law in 2011 as a “diagnostic event” (Moore in Am Ethnol 14(4):727–736, 1987), I examine the debate in order to unravel the underlying logic and ongoing dynamics of the psycho-boom that has become a conspicuous trend in urban China since the early 2000s. Drawing on my fieldwork in Beijing and Shanghai, I use the two keywords of the debate—“jianghu” (literally “rivers and lakes”), an indigenous term that evokes an untamed realm, and “profession,” a foreign concept whose translation requires re-translation—to organize my delineation of its contours. I describe how anticipation of state regulation prompted fears and discontents as well as critical reflections and actions that aimed to transform the field into a profession. The efforts to mark out a professional core against the backdrop of unruly jianghu further faced the challenge of an alternative vision that saw popularization as an equally noble cause. The Mental Health Law came into effect in 2013; ultimately, however, it did not introduce substantive regulation. Finally, I discuss the implications of this debate and the prospects of the psycho-boom.     

Life Cycle Attribute Assessment

Practitioners of life cycle assessment (LCA) have recently turned their attention to social issues in the supply chain. The United Nations life cycle initiative's social LCA task force has completed its guidelines for social life cycle assessment of products, and awareness of managing upstream corporate social responsibility (CSR) issues has risen due to the growing popularity of LCA. This article explores one approach to assessing social issues in the supply chain—life cycle attribute assessment (LCAA). The approach was originally proposed by Gregory Norris in 2006, and we present here a case study. LCAA builds on the theoretical structure of environmental LCA to construct a supply chain model. Instead of calculating quantitative impacts, however, it asks the question “What percentage of my supply chain has attribute X?” X may represent a certification from a CSR body or a self‐defined attribute, such as “is locally produced.” We believe LCAA may serve as an aid to discussions of how current and popular CSR indicators may be integrated into a supply chain model. The case study demonstrates the structure of LCAA, which is very similar to that of traditional environmental LCA. A labor hours data set was developed as a satellite matrix to determine number of worker hours in a greenhouse tomato supply. Data from the Quebec tomato producer were used to analyze how the company performed on eight sample LCAA indicators, and conclusions were drawn about where the company should focus CSR efforts.