共查询到20条相似文献,搜索用时 0 毫秒
1.
F. Richard Ellis Niall P. Keaney D. G. F. Harriman D. W. Sumner K. Kyei-Mensah J. H. Tyrrell J. B. Hargreaves R. K. Parikh P. L. Mulrooney 《BMJ (Clinical research ed.)》1972,3(5826):559-561
The methods used to screen patients for malignant hyperpyrexia at present are not sufficiently accurate. This paper reports more specific methods of detecting patients liable to develop malignant hyperpyrexia. A motor-point muscle biopsy is performed for histopathological examination and to detect muscle contracture in vitro after exposure to halothane and suxamethonium. 相似文献
2.
The caffeine contracture of normal human muscle, which has been used as a model for malignant hyperpyrexia, is greatly potentiated by halothane. Prior administration of procaine markedly reduces the halothane-potentiated caffeine contracture, and procaine given at the height of the contracture induces relaxation. Lignocaine, on the other hand, produces a variable response and sometimes increases the contracture.The muscle from a patient with an inherited susceptibility to malignant hyperpyrexia contracted spontaneously with halothane alone, and this contracture was reversed by procaine.These experiments support the therapeutic use of procaine in malignant hyperpyrexia. 相似文献
3.
M. A. Denborough G. L. Warne R. F. W. Moulds P. Tse F. I. R. Martin 《BMJ (Clinical research ed.)》1974,3(5929):493-495
An increased glucose-induced insulin response has been observed in patients susceptible to malignant hyperpyrexia. This raises the possibility that the membrane abnormality present in the calcium-storing membranes in the muscle cell in malignant hyperpyrexia may be present also in the beta cell of the pancreas. 相似文献
4.
While the serum level of creatine phosphokinase is useful as a screening test for malignant hyperpyrexia it does not provide certain identification of susceptible individuals. A much more accurate prediction may be made by pharmacological testing in vitro of muscle biopsy specimens. Individuals susceptible to malignant hyperpyrexia have muscle with heightened sensitivity to halothane, caffeine, succinylcholine, potassium chloride, and temperature change. Use of this test allows separation of susceptible individuals from those not at risk in families of patients who have experienced malignant hyperpyrexia. 相似文献
5.
Gaisford G. Harrison 《BMJ (Clinical research ed.)》1971,3(5772):454-456
Experiments in susceptible Landrace pigs have shown that procaine blocks the initiation of anaesthetic-induced malignant hyperpyrexia by both halothane and succinylcholine. Pretreatment with curare prevents only the trigger action of succinylcholine. In a preliminary study procaine was used to treat the established syndrome in five pigs, two of which survived. On the basis of these findings a treatment regimen can be suggested for patients who develop malignant hyperpyrexia. 相似文献
6.
7.
8.
Herbert Y. Reynolds 《The Yale journal of biology and medicine》1978,51(1):97-Feb;51(1):97
9.
10.
11.
Biochemical and Molecular Genetic Basis of Hydrogenases 总被引:1,自引:0,他引:1
Hydrogenases catalyse the reversible reduction of protons to molecular hydrogen. Applied research is focused on structure and catalytic function under the aspect of hydrogen formation. In this review we summarize the current knowledge about properties and physiological roles of hydrogenases in pro- and eukaryotes and compile molecular genetical data about structural features of prokaryotic hydrogenases. Finally, prospects are given for the possible application of hydrogenases or ‘hydrogenase-like catalysts’ in energy production. 相似文献
12.
R. Cecil Brown 《BMJ (Clinical research ed.)》1954,2(4903):1526-1527
13.
14.
G. G. Harrison J. F. Biebuyck J. Terblanche D. M. Dent R. Hickman S. J. Saunders 《BMJ (Clinical research ed.)》1968,3(5618):594-595
Work in pigs has shown that malignant hyperpyrexia during anaesthesia may occur without suxamethonium having been given. A virtually constant feature in reported cases and in our own observations is that all subjects developing hyperpyrexia had received nitrous oxide and halothane. 相似文献
15.
Alan B. Hooper 《Journal of bacteriology》1969,97(2):776-779
The specific activities of isocitric dehydrogenase, alpha-ketoglutaric dehydrogenase, succinic dehydrogenase, malic dehydrogenase, and reduced nicotinamide adenine dinucleotide (NADH) oxidase were determined in extracts of Nitrosomonas europaea and compared with the corresponding values for Anacystis nidulans and autotrophically grown Hydrogenomonas eutropha. In common with other obligate autotrophs and in contrast to facultative autotrophs, Nitrosomonas extracts lacked alpha-ketoglutaric dehydrogenase and KCN-sensitive NADH oxidase activity and had low succinic dehydrogenase activity. The Nitrosomonas NADH oxidase appeared to be of the peroxidase type. 相似文献
16.
17.
18.
19.
Brajesh Kumar Singh Ramesh Chander Kuhad Ajay Singh Rup Lal K. K. Tripathi 《Critical reviews in biotechnology》2013,33(3):197-225
AbstractFungal arachidonic acid (ARA)-rich oil is an important microbial oil that affects diverse physiological processes that impact normal health and chronic disease. In this article, the historic developments and technological achievements in fungal ARA-rich oil production in the past several years are reviewed. The biochemistry of ARA, ARA-rich oil synthesis and the accumulation mechanism are first introduced. Subsequently, the fermentation and downstream technologies are summarized. Furthermore, progress in the industrial production of ARA-rich oil is discussed. Finally, guidelines for future studies of fungal ARA-rich oil production are proposed in light of the current progress, challenges and trends in the field. 相似文献
20.