Gender in the Muslim Middle East

Feminists, Islam, and Nation: Gender and the Making of Modern Egypt. Margot Badran. Princeton, NJ: Princeton University Press, 1995. 352 pp.
Gender Politics in Sudan: Islamism, Socialism, and the State. Sondra Hale. Boulder, CO. Westview Press, 1996. 294 pp.
Quest for Conception: Gender, Infertility, and Egyptian Medical Traditions. Marcia C. Inhorn. Philadelphia: University of Pennsylvania Press, 1994. 441 pp.     

Visual Revolutions in the Middle East

Five years ago images from the Arab uprisings revealed a renewed investment in political visibility. Despite the brutal outcome of most of these revolts, the centrality of seeing for understanding the dynamics of political vision and struggle in the region remains salient. Images serve as important touchstones around which political narratives emerge and cohere. In this special issue on Visual Revolutions in the Middle East, seven scholars— Diana K. Allan, Zeynep Devrim Gürsel, Alisa Lebow, Peter Limbrick, Anjali Nath, Peter Snowdon and Mark R. Westmoreland—bring interdisciplinary attention to the generative possibilities of image-making in sites of political contestation. Whether through archival remnants, mobile screen technologies or the lens of a camera, the contributors to this collection explore the image as an agent of expression, engagement and critique, operating at the interface between political desires and evidentiary forms of visuality.     

Children in the Muslim Middle East

Children in the Muslim Middle East. Elizabeth Warnock Fernea. Austin: University of Texas Press, 1995.477 pp.     

Sandfly Fever Sicilian Virus-Leishmania major co-infection modulates innate inflammatory response favoring myeloid cell infections and skin hyperinflammation

BackgroundThe leishmaniases are a group of sandfly-transmitted diseases caused by species of the protozoan parasite, Leishmania. With an annual incidence of 1 million cases, 1 billion people living in Leishmania-endemic regions, and nearly 30,000 deaths each year, leishmaniasis is a major global public health concern. While phlebotomine sandflies are well-known as vectors of Leishmania, they are also the vectors of various phleboviruses, including Sandfly Fever Sicilian Virus (SFSV).Cutaneous leishmaniasis (CL), caused by Leishmania major (L. major), among other species, results in development of skin lesions on the infected host. Importantly, there exists much variation in the clinical manifestation between individuals. We propose that phleboviruses, vectored by and found in the same sandfly guts as Leishmania, may be a factor in determining CL severity. It was reported by our group that Leishmania exosomes are released into the gut of the sandfly vector and co-inoculated during blood meals, where they exacerbate CL skin lesions. We hypothesized that, when taking a blood meal, the sandfly vector infects the host with Leishmania parasites and exosomes as well as phleboviruses, and that this viral co-infection results in a modulation of leishmaniasis.Methodology/Principal findingsIn vitro, we observed modulation by SFSV in MAP kinase signaling as well as in the IRF3 pathway that resulted in a pro-inflammatory phenotype. Additionally, we found that SFSV and L. major co-infection resulted in an exacerbation of leishmaniasis in vivo, and by using endosomal (Toll-like receptor) TLR3, and MAVS knock-out mice, deduced that SFSV’s hyperinflammatory effect was TLR3- and MAVS-dependent. Critically, we observed that L. major and SFSV co-infected C57BL/6 mice demonstrated significantly higher parasite burden than mice solely infected with L. major. Furthermore, viral presence increased leukocyte influx in vivo. This influx was accompanied by elevated total extracellular vesicle numbers. Interestingly, L. major displayed higher infectiveness with coincident phleboviral infection compared to L. major infection alone.Conclusion/SignificanceOverall our work represents novel findings that contribute towards understanding the causal mechanisms governing cutaneous leishmaniasis pathology. Better comprehension of the potential role of viral co-infection could lead to treatment regimens with enhanced effectiveness.