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1.
A highly fecund inbred mouse line has been established from the Quackenbush Swiss (QS) outbred strain by full-sib inbreeding combined with selection for high number of pups born alive (NBA) and low interlitter interval (ILI). After more than 50 generations of inbreeding and selection, this line, named QSi5, has an NBA of 13.4 and an ILI of 29 days, averaged over the first four parities, and a total productivity of 50.7 NBA. With its exceptional reproductive performance, this line will be very useful in the creation of resources (including advanced intercross lines) for analysis of quantitative trait loci for a wide range of traits, and for the cost-effective creation of congenic lines. 相似文献
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G B Kirillicheva M S Solov'eva I G Baturina T N Shchukovskaia G A Maslennikov 《Biulleten' eksperimental'no? biologii i meditsiny》1992,113(3):296-297
The activity of 5'-nucleotidase of peritoneal exudate in subcutaneous injection of histamine in a dose of 1.0-100 microliters was studied in mice of different lines (CBA, C57, B1/6, Balb/c, NFS/n, NFR/n). There were interline differences in the influence of histamine on this metabolic index. 相似文献
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Males of inbred strains were orally given lead acetate water solution during 150 days. Changes were found in the structure of the seminiferous tubules and in spermatozoa. The pathological changes in Leydig cells brought about a decline in levels of androgens. 相似文献
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Hierarchical relationship between bone traits and mechanical properties in inbred mice 总被引:2,自引:2,他引:0
Abstract
Osteoporotic fracture incidence and underlying risk factors like low peak bone mass are heritable, but the genetic basis of
osteoporosis remains poorly understood. Based on beam theory, stating that mechanical properties of a structure depend on
both the amount and quality of the constituent materials, we investigated the relationship between whole bone mechanical properties
and a set of morphological and compositional traits in femurs of eight inbred mouse strains. K-means cluster analysis revealed
that individual femora could be classified reliably according to genotype based on the combination of bone area (tissue amount),
moment of inertia (tissue distribution), and ash content (tissue quality). This trait combination explained 66–88% of the
inter-strain variability in four whole-bone mechanical properties that describe all aspects of the failure process, including
measures of brittleness. Stiffness and maximum load were functionally associated with cortical area, while measures of brittleness
were associated with ash content. In contrast, work-to-failure was not directly related to a single trait but depended on
a combination of trait magnitudes. From these findings, which were entirely consistent with established mechanical theory,
we developed a hierarchical paradigm relating the mechanical properties that define bone fragility with readily measurable
phenotypic traits that exhibit strong heritability. This paradigm will help guide the search for genes that underlie fracture
susceptibility and osteoporosis. Moreover, because the traits we examined are measurable with non-invasive means, this approach
may also prove directly applicable to osteoporosis risk assessment. 相似文献
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Absence of pregnancy-block in mice when stud and test males belong to an inbred strain 总被引:2,自引:0,他引:2
H M Bruce 《Journal of reproduction and fertility》1968,17(2):407-408
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The inbred mouse strain DDD was found to have an extremely high incidence of hydronephrosis (37/37 in adult males and 12/32 in adult females). The hydronephrosis was classified as open with no definite cause for obstruction. The condition was either unilateral in the right kidney or bilateral. Another feature of the hydronephrotic kidney was circulatory failure. Hydronephrosis in strain DDD mice is considered to be a useful experimental animal model with additional possible use, in investigating disturbances of renal haemodynamics and function. 相似文献
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M A Savina 《Parazitologiia》1986,20(5):413-416
Distinct differences in the intensity and dynamics of the infection with cysts of toxoplasms of law virulent (Czech) strain of brain of mice of three different pure lines and strainless ones differing in the sensitivity to the agent during a chronic period of infection have been noted. In sensitive mice of AKR line the period of formation and growth of cysts as well as the period of their elimination from the brain is longer than in less sensitive ones. In this connection cysts in the brain of these mice turned out to be larger than in the brain of less sensitive mice of CC57BR line. Activation of the infection in the brain, revealed microscopically, is observed most commonly in mice of AKR line (40%), more seldom in CC57BR (9.1%) and strainless ones (7.7%) and is not observed at all in resistent BALB/c. Lethality of these mice was by 9 months of infection 87, 40, 41 and 5.3%, respectively. 1-1.5 year after the infection in animals without relapses the infection level of brain was equally low. 相似文献
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Appropriately immunized mice display a response that is biologically equivalent to rat rapid expulsion. Only two inbred strains ( derived from NIH Swiss mice) have been shown to respond in this manner. Mice of the , CBA, , C3H, SJL, or C57Bl strains are “nonresponders” which require approximately twice as much intestinal exposure (in days) to Trichinella spiralis to elicit a response half as effective. Genetically, the responder is dominant, autosomal, and does not appear to be linked to the MHC. The characteristics of mouse and rat rapid expulsion of T. spiralis are not identical but share these features: initial rejection within 24 hr of challenge; a rejection efficiency >90%, from 1 to 5 weeks after the primary; induction of response does not require exposure to the complete infection; rapid expulsion is immunologically specific for preadults; adult worms are resistant. While a genetic basis for responsiveness exists in mice there is, as yet, no evidence for genetic control in rats. In both mice and rats, rapid expulsion is distinguished from the intestinal hyperreactivity associated with rejection of the primary infection by the kinetics and amplitude of the rejection of transplanted adult worms. 相似文献
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E. R. Soares 《Biochemical genetics》1979,17(7-8):577-583
A new allele of Es-1, designated Es-1
e, has been identified in the mouse. This allele was discovered segregating among the progeny of a strain DBA/2J male and is apparently the result of a spontaneous mutation within this strain. Genetic analyses have shown that this mutation is heritable and, further, that both heterozygous and homozygous progeny are viable and fertile. To date, no discernible deleterious effects have been identified as associated with this mutation. 相似文献
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L S Nazarova I V Isupov L P Pavlova A V Gor'kova V A Dushkin 《Biulleten' eksperimental'no? biologii i meditsiny》1988,105(6):761-764
The data obtained during the study of the morphological changes in the internal organs and blood of 6 mouse strains at the early stages of anti-plague immunity are presented. It has been established that the introduction of 5.10(3) and 1.10(5) m. b. of the EV vaccine strain resulted in the development of morphological changes typical of residual virulence. The degree of these changes depended on the haplotype of the animals and the dose used. The most resistant to injury induced by EV strain were CBA mice (haplotype H-2k) and the most sensitive were C57BL/6 mice (haplotype H-2b). 相似文献
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Spontaneous hydronephrosis in the inbred mouse strain NZC 总被引:1,自引:0,他引:1
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The mode of inheritance of hydronephrosis was investigated by crossing inbred DDD mice having a high incidence of hydronephrosis and C57BL/6 mice having normal kidneys. In the males, incidences of hydronephrosis in F1 animals were intermediate between the two parental strains at a rate of 32.6% in (DDD x C57BL/6)F1 and 23.4% in reciprocal F1. The same tendency was observed in F2 male animals. In BCF1 males, the number of affected mice was higher in (C57BL/6 x DDD) F1 x DDD (72.4%) than in (DDD x C57BL/6)F1 x C57BL/6 (11.1%). A few affected mice were found among the females of hybrids F1, F2 and BCF1. These results suggested that hydronephrosis in the DDD strain of mice was controlled by polygenes, and that male hormones may have some effect on the occurrence of hydronephrosis. 相似文献
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David W. Threadgill Delia Yee Argabin Matin Joseph H. Nadeau Terry Magnuson 《Mammalian genome》1997,8(6):390-393
The 129 mouse is the most widely used strain in gene targeting experiments. However, numerous substrains exist with demonstrable
physiological differences. In this study a set of simple sequence length polymorphisms (SSLPs) was used to determine the relatedness
of selected 129 substrains. 129/SvJ was significantly different from the other 129 substrains and is more accurately classified
as a recombinant congenic strain (129cX/Sv), being derived from 129/Sv and an unknown strain. This mixed genetic background
could complicate gene targeting experiments by reducing homologous recombination efficiency when constructs and ES cells are
not derived from the same 129 substrain. Additionally, discrepancies due to different genetic backgrounds may arise when comparing
phenotypes of genes targeted in different 129-derived ES cell lines.
Received: 2 December 1996 / Accepted: 10 February 1997 相似文献