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Sex-specific gene regulation. The Doublesex DM motif is a bipartite DNA-binding domain 总被引:1,自引:0,他引:1
Narendra U Zhu L Li B Wilken J Weiss MA 《The Journal of biological chemistry》2002,277(45):43463-43473
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Background:
The DM domain is a zinc finger-like DNA binding motif first identified in the sexual regulatory proteins Doublesex (DSX) and MAB-3, and is widely conserved among metazoans. DM domain proteins regulate sexual differentiation in at least three phyla and also control other aspects of development, including vertebrate segmentation. Most DM domain proteins share little similarity outside the DM domain. DSX and MAB-3 bind partially overlapping DNA sequences, and DSX has been shown to interact with DNA via the minor groove without inducing DNA bending. DSX and MAB-3 exhibit unusually high DNA sequence specificity relative to other minor groove binding proteins. No detailed analysis of DNA binding by the seven vertebrate DM domain proteins, DMRT1-DMRT7 has been reported, and thus it is unknown whether they recognize similar or diverse DNA sequences. 相似文献5.
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Lannoy VJ Rodolosse A Pierreux CE Rousseau GG Lemaigre FP 《The Journal of biological chemistry》2000,275(29):22098-22103