共查询到20条相似文献,搜索用时 31 毫秒
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A M Musti V M Ursini E V Avvedimento V Zimarino R Di Lauro 《Nucleic acids research》1987,15(20):8149-8166
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M F Norman T N Lavin J D Baxter B L West 《The Journal of biological chemistry》1989,264(20):12063-12073
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Thyroid hormone regulates the mouse thyrotropin beta-subunit gene promoter in transfected primary thyrotropes 总被引:13,自引:0,他引:13
W M Wood M Y Kao D F Gordon E C Ridgway 《The Journal of biological chemistry》1989,264(25):14840-14847
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5'-Flanking DNA of the rat growth hormone gene mediates regulated expression by thyroid hormone 总被引:10,自引:0,他引:10
J Casanova R P Copp L Janocko H H Samuels 《The Journal of biological chemistry》1985,260(21):11744-11748
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Thyroid-stimulating-hormone-alpha (TSH-α) is the common subunit of the heterodimeric hormone TSH and also of other glycoprotein hormones. Although both expression and promoter-methylation profiles of the gene have been observed in the pituitary gland and placenta, no observation has been reported in the thyroid gland. We examined TSH-α expression in normal and cancer thyroid tissues. Real-time RT-PCR and immunohistochemistry indicated that TSH-a was repressed in normal tissues while activated in cancer tissues. To identify the epigenetic mechanism of upregulation of TSH-α, the methylation status of the seven CpG sites in the TSH-a promoter was examined in sixty thyroid cancer tissues. Two CpG sites showed remarkably higher levels of methylation in cancer (46 and 45%) than in normal tissues (24 and 23%) (p=0.010 and 0.003). These findings indicate that TSH-α is expressed in the thyroid cancer tissue per se and that its expression can be affected by promoter methylation. 相似文献
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