共查询到20条相似文献,搜索用时 31 毫秒
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Gusterson RJ Jazrawi E Adcock IM Latchman DS 《The Journal of biological chemistry》2003,278(9):6838-6847
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The major histocompatibility complex (MHC) class II transactivator (CIITA) regulates the expression of genes involved in the immune response, including MHC class II genes and the interleukin-4 gene. Interactions between CIITA and sequence-specific, DNA-binding proteins are required for CIITA to function as an activator of MHC class II genes. CIITA also interacts with the coactivators CBP (also called p300), and this interaction leads to synergistic activation of MHC class II promoters. Here, we report that CIITA forms complexes with itself and that a central region, including the GTP-binding domain is sufficient for self-association. Additionally, this central region interacts with the C-terminal leucine-rich repeat as well as the N-terminal acidic domain. LXXLL motifs residing in the GTP-binding domain are essential for self-association. Finally, distinct differences exist among various CIITA mutant proteins with regard to activation function, subcellular localization, and association with wild-type protein and dominant-negative potential. 相似文献
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Acetylation of nucleosomal histones by p300 facilitates transcription from tax-responsive human T-cell leukemia virus type 1 chromatin template
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Lu H Pise-Masison CA Fletcher TM Schiltz RL Nagaich AK Radonovich M Hager G Cole PA Brady JN 《Molecular and cellular biology》2002,22(13):4450-4462
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Kavita Purnanda Bhat Agnieszka Dorota Truax Susanna Fletcher Greer 《The Journal of biological chemistry》2010,285(34):25893-25903
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Gobin SJ Biesta P de Steenwinkel JE Datema G van den Elsen PJ 《The Journal of biological chemistry》2002,277(42):39525-39531