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FOG acts as a repressor of red blood cell development in Xenopus 总被引:4,自引:0,他引:4
Deconinck AE Mead PE Tevosian SG Crispino JD Katz SG Zon LI Orkin SH 《Development (Cambridge, England)》2000,127(10):2031-2040
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GATA-1 and FOG (Friend of GATA-1) are each essential for erythroid and megakaryocyte development. FOG, a zinc finger protein, interacts with the amino (N) finger of GATA-1 and cooperates with GATA-1 to promote differentiation. To determine whether this interaction is critical for GATA-1 action, we selected GATA-1 mutants in yeast that fail to interact with FOG but retain normal DNA binding, as well a compensatory FOG mutant that restores interaction. These novel GATA-1 mutants do not promote erythroid differentiation of GATA-1- erythroid cells. Differentiation is rescued by the second-site FOG mutant. Thus, interaction of FOG with GATA-1 is essential for the function of GATA-1 in erythroid differentiation. These findings provide a paradigm for dissecting protein-protein associations involved in mammalian development. 相似文献
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GATA-6 activates transcription of surfactant protein A 总被引:8,自引:0,他引:8
Bruno MD Korfhagen TR Liu C Morrisey EE Whitsett JA 《The Journal of biological chemistry》2000,275(2):1043-1049
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Phosphatidylinositol 3-kinase/Akt induced by erythropoietin renders the erythroid differentiation factor GATA-1 competent for TIMP-1 gene transactivation
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Kadri Z Maouche-Chretien L Rooke HM Orkin SH Romeo PH Mayeux P Leboulch P Chretien S 《Molecular and cellular biology》2005,25(17):7412-7422
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Boudreau F Rings EH van Wering HM Kim RK Swain GP Krasinski SD Moffett J Grand RJ Suh ER Traber PG 《The Journal of biological chemistry》2002,277(35):31909-31917