共查询到20条相似文献,搜索用时 453 毫秒
1.
Lihua J Zhu Claude Gazin Nathan D Lawson Hervé Pagès Simon M Lin David S Lapointe Michael R Green 《BMC bioinformatics》2010,11(1):237
Background
Chromatin immunoprecipitation (ChIP) followed by high-throughput sequencing (ChIP-seq) or ChIP followed by genome tiling array analysis (ChIP-chip) have become standard technologies for genome-wide identification of DNA-binding protein target sites. A number of algorithms have been developed in parallel that allow identification of binding sites from ChIP-seq or ChIP-chip datasets and subsequent visualization in the University of California Santa Cruz (UCSC) Genome Browser as custom annotation tracks. However, summarizing these tracks can be a daunting task, particularly if there are a large number of binding sites or the binding sites are distributed widely across the genome. 相似文献2.
NELF and GAGA factor are linked to promoter-proximal pausing at many genes in Drosophila 总被引:1,自引:0,他引:1
Lee C Li X Hechmer A Eisen M Biggin MD Venters BJ Jiang C Li J Pugh BF Gilmour DS 《Molecular and cellular biology》2008,28(10):3290-3300
3.
4.
5.
The ChIP-chip and ChIP-seq techniques enable genome-wide mapping of in vivo protein-DNA interactions and chromatin states. The cross-platform and between-laboratory variation poses a challenge to the
comparison and integration of results from different ChIP experiments. We describe a novel method, MM-ChIP, which integrates
information from cross-platform and between-laboratory ChIP-chip or ChIP-seq datasets. It improves both the sensitivity and
the specificity of detecting ChIP-enriched regions, and is a useful meta-analysis tool for driving discoveries from multiple
data sources. 相似文献
6.
7.
8.
9.
10.
11.
12.
《Epigenetics》2013,8(6):318-321
Next-generation sequencing is poised to unleash dramatic changes in every area of molecular biology. In the past few years, chromatin immunoprecipitation (ChIP) on tiled microarrays (ChIP-chip) has been an important tool for genome-wide mapping of DNA-binding proteins or histone modifications. Now, ChIP followed by direct sequencing of DNA fragments (ChIP-seq) offers superior data with less noise and higher resolution and is likely to replace ChIP-chip in the near future. We will describe advantages of this new technology and outline some of the issues in dealing with the data. ChIP-seq generates considerably larger quantities of data and the most challenging aspect for investigators will be computational and statistical analysis necessary to uncover biological insights hidden in the data. 相似文献
13.
14.
15.
16.
17.
18.
19.
Sandip De David M Edwards Vibha Dwivedi Jianming Wang Wazeer Varsally Hannah
L Dixon Anand
K Singh Precious O Owuamalam Matthew T Wright Reece P Summers Md Nazmul Hossain Emily
M Price Marcin
W Wojewodzic Francesco Falciani Nikolas J Hodges Marco Saponaro Kayoko Tanaka Claus M Azzalin Peter Baumann Daniel Hebenstreit Saverio Brogna 《Nucleic acids research》2022,50(1):350