共查询到20条相似文献,搜索用时 15 毫秒
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Human STAGA complex is a chromatin-acetylating transcription coactivator that interacts with pre-mRNA splicing and DNA damage-binding factors in vivo 总被引:7,自引:0,他引:7 下载免费PDF全文
Martinez E Palhan VB Tjernberg A Lymar ES Gamper AM Kundu TK Chait BT Roeder RG 《Molecular and cellular biology》2001,21(20):6782-6795
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A TFTC/STAGA module mediates histone H2A and H2B deubiquitination, coactivates nuclear receptors, and counteracts heterochromatin silencing 总被引:3,自引:0,他引:3
Zhao Y Lang G Ito S Bonnet J Metzger E Sawatsubashi S Suzuki E Le Guezennec X Stunnenberg HG Krasnov A Georgieva SG Schüle R Takeyama K Kato S Tora L Devys D 《Molecular cell》2008,29(1):92-101
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Frank SR Parisi T Taubert S Fernandez P Fuchs M Chan HM Livingston DM Amati B 《EMBO reports》2003,4(6):575-580
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Flinn EM Wallberg AE Hermann S Grant PA Workman JL Wright AP 《The Journal of biological chemistry》2002,277(26):23399-23406
The N-terminal domain of c-Myc plays a key role in cellular transformation and is involved in both activation and repression of target genes as well as in modulated proteolysis of c-Myc via the proteasome. Given this functional complexity, it has been difficult to clarify the structures within the N terminus that contribute to these different processes as well as the mechanisms by which they function. We have used a simplified yeast model system to identify the primary determinants within the N terminus for (i) chromatin remodeling of a promoter, (ii) gene activation from a chromatin template in vivo, and (iii) interaction with highly purified Gcn5 complexes as well as other chromatin-remodeling complexes in vitro. The results identify two regions that contain autonomous chromatin opening and gene activation activity, but both regions are required for efficient interaction with chromatin-remodeling complexes in vitro. The conserved Myc boxes do not play a direct role in gene activation, and Myc box II is not generally required for in vitro interactions with remodeling complexes. The yeast SAGA complex, which is orthologous to the human GCN5-TRRAP complex that interacts with Myc in human cells, plays a role in Myc-mediated chromatin opening at the promoter but may also be involved in later steps of gene activation. 相似文献
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