Xenopus connexins: how frogs bridge the gap

Animal species use specialized cell-to-cell channels, called gap junctions, to allow for a direct exchange of ions and small metabolites between their cells' cytoplasm. In invertebrates, gap junctions are formed by innexins, while vertebrates use connexin (Cx) proteins as gap-junction-building blocks. Recently, innexin homologs have been found in vertebrates and named pannexins. From progress in the different genome projects, it has become evident that every class of vertebrates uses their own unique set of Cxs to build their gap junctions. Here, we review all known Xenopus Cxs with respect to their expression, regulation, and function. We compare Xenopus Cxs with those of zebrafish and mouse, and provide evidence for the existence of several additional, non-identified, amphibian Cxs. Finally, we identify two new Xenopus pannexins by screening EST libraries.     

Why the leopard got its spots: relating pattern development to ecology in felids

A complete explanation of the diversity of animal colour patterns requires an understanding of both the developmental mechanisms generating them and their adaptive value. However, only two previous studies, which involved computer-generated evolving prey, have attempted to make this link. This study examines variation in the camouflage patterns displayed on the flanks of many felids. After controlling for the effects of shared ancestry using a fully resolved molecular phylogeny, this study shows how phenotypes from plausible felid coat pattern generation mechanisms relate to ecology. We found that likelihood of patterning and pattern attributes, such as complexity and irregularity, were related to felids' habitats, arboreality and nocturnality. Our analysis also indicates that disruptive selection is a likely explanation for the prevalence of melanistic forms in Felidae. Furthermore, we show that there is little phylogenetic signal in the visual appearance of felid patterning, indicating that camouflage adapts to ecology over relatively short time scales. Our method could be applied to any taxon with colour patterns that can reasonably be matched to reaction-diffusion and similar models, where the kinetics of the reaction between two or more initially randomly dispersed morphogens determines the outcome of pattern development.