共查询到20条相似文献,搜索用时 671 毫秒
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Background
Microarray technology allows simultaneous measurement of thousands of genes in a single experiment. This is a potentially useful tool for evaluating co-expression of genes and extraction of useful functional and chromosomal structural information about genes. 相似文献2.
Background
The metastatic ability of tumor cells is determined by level of expression of specific genes that may be identified with the aid of cDNA microarray containing thousands of genes and can be used to establish the expression profile of disease related genes in complex biological system. 相似文献3.
Nuno A Fonseca Cristina P Vieira Peter WH Holland Jorge Vieira 《BMC evolutionary biology》2008,8(1):200
Background
Although homeobox genes have been the subject of many studies, little is known about the main amino acid changes that occurred early in the evolution of genes belonging to different classes. 相似文献4.
Mariana Conte Silvia de Simone Susan J Simmons Carlos L Ballaré Ann E Stapleton 《BMC plant biology》2010,10(1):112
Background
Understanding of the genetic architecture of plant UV-B responses allows extensive targeted testing of candidate genes or regions, along with combinations of those genes, for placement in metabolic or signal transduction pathways. 相似文献5.
Background
One of the important goals of microarray research is the identification of genes whose expression is considerably higher or lower in some tissues than in others. We would like to have ways of identifying such tissue-specific genes. 相似文献6.
Maayan Amit Noa Sela Hadas Keren Ze'ev Melamed Inna Muler Noam Shomron Shai Izraeli Gil Ast 《BMC molecular biology》2007,8(1):109
Background
Gene duplication and exonization of intronic transposed elements are two mechanisms that enhance genomic diversity. We examined whether there is less selection against exonization of transposed elements in duplicated genes than in single-copy genes. 相似文献7.
Alexander Y Panchin Mikhail S Gelfand Vasily E Ramensky Irena I Artamonova 《Biology direct》2010,5(1):54
Background
Gene duplications are a source of new genes and protein functions. The innovative role of duplication events makes families of paralogous genes an interesting target for studies in evolutionary biology. Here we study global trends in the evolution of human genes that resulted from recent duplications. 相似文献8.
Background
Microarray experiments, as well as other genomic analyses, often result in large gene sets containing up to several hundred genes. The biological significance of such sets of genes is, usually, not readily apparent. 相似文献9.
Debra T Burhans Lakshmi Ramachandran Jianxin Wang Ping Liang Hugh G Patterton Michael Breitenbach William C Burhans 《BMC evolutionary biology》2006,6(1):58
Background
Coordinately regulated genes often physically cluster in eukaryotic genomes, for reasons that remain unclear. 相似文献10.
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In search of suitable reference genes for gene expression studies of human renal cell carcinoma by real-time PCR 总被引:1,自引:0,他引:1
Monika Jung Azizbek Ramankulov Jan Roigas Manfred Johannsen Martin Ringsdorf Glen Kristiansen Klaus Jung 《BMC molecular biology》2007,8(1):47
Background
Housekeeping genes are commonly used as endogenous reference genes for the relative quantification of target genes in gene expression studies. No conclusive systematic study comparing the suitability of different candidate reference genes in clear cell renal cell carcinoma has been published to date. To remedy this situation, 10 housekeeping genes for normalizing purposes of RT-PCR measurements already recommended in various studies were examined with regard to their usefulness as reference genes. 相似文献14.
Background
Earlier methods for detecting major genes responsible for a quantitative trait rely critically upon a well-structured pedigree in which the segregation pattern of genes exactly follow Mendelian inheritance laws. However, for many outcrossing species, such pedigrees are not available and genes also display population properties. 相似文献15.
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Alan Villalobos Jon E Ness Claes Gustafsson Jeremy Minshull Sridhar Govindarajan 《BMC bioinformatics》2006,7(1):285-8
Background
Direct synthesis of genes is rapidly becoming the most efficient way to make functional genetic constructs and enables applications such as codon optimization, RNAi resistant genes and protein engineering. Here we introduce a software tool that drastically facilitates the design of synthetic genes. 相似文献17.
Chia-Huei Lee Chih-Min Liu Chun-Chiang Wen Shun-Min Chang Hai-Gwo Hwu 《Journal of biomedical science》2010,17(1):2
Background
Schizophrenia is a complex disorder with involvement of multiple genes. 相似文献18.
Barbara Hutter Matthias Bieg Volkhard Helms Martina Paulsen 《BMC evolutionary biology》2010,10(1):116
Background
In contrast to the majority of mammalian genes, imprinted genes are monoallelically expressed with the choice of the active allele depending on its parental origin. Due to their special inheritance patterns, maternally and paternally expressed genes might be under different evolutionary pressure. Here, we aimed at assessing the evolutionary history of imprinted genes. 相似文献19.
Mark TA Donoghue Channa Keshavaiah Sandesh H Swamidatta Charles Spillane 《BMC evolutionary biology》2011,11(1):47
Background
All sequenced genomes contain a proportion of lineage-specific genes, which exhibit no sequence similarity to any genes outside the lineage. Despite their prevalence, the origins and functions of most lineage-specific genes remain largely unknown. As more genomes are sequenced opportunities for understanding evolutionary origins and functions of lineage-specific genes are increasing. 相似文献20.
Peter Kharchenko Lifeng Chen Yoav Freund Dennis Vitkup George M Church 《BMC bioinformatics》2006,7(1):177-16