共查询到20条相似文献,搜索用时 31 毫秒
2.
3.
成纤维细胞生长因子9(FGF9)的研究进展 总被引:1,自引:0,他引:1
成纤维细胞生长因子9(fibroblast growth factor 9,FGF9)是成纤维细胞生长因子家族(FGFs)的成员之一。广泛分布于人体各种组织中,它参与骨骼发育、血管形成、胚胎发育、损伤修复、细胞凋亡、神经再生、肿瘤生长等多种生理和病理的过程,可有效促进有丝分裂和细胞生长。研究发现,FGF9不仅在骨骼发育和生长期对软骨形成和成骨生成起着重要的作用,而且对卵巢癌的发生、神经再生、性腺分化等方面也有重要的影响,对FGF9作为一个有用治疗靶点发挥作用的功能和机制仍有待进一步的发现及研究。现针对FGF9的特点,综述了其在表达及适应征机制方面的研究进展,为FGF9进一步的研究及合理开发利用提供参考。 相似文献
4.
Alibek Kazhgaly uly Malayev 《Visual Anthropology: Published in cooperation with the Commission on Visual Anthropology》2013,26(4):285-302
In this article the author offers an original interpretation of patterns found on the world's most ancient felts (Fifth Century BCE). These artifacts have been recovered from frozen burial mounds in the Altai Mountains. The interpretation presented here constitutes a new approach to the study of ornamentation as a system of symbols. 相似文献
5.
6.
7.
8.
使用多种生物信息学工具来预测、比较尘螨变应原Der f 9、Der p 9和Blo t 9的一级、二级、三级结构及抗原表位,找出3种蛋白结构及功能的异同。Der f 9、Der p 9和Blo t 9氨基酸序列一致性为82.07%,都含有3个胰蛋白酶活性位点氨基酸及2个功能结构区特异性序列;二级和三级结构中都由α-螺旋、β-折叠和无规卷曲组成;活性位点氨基酸在三级结构中完全重合,并相互靠近构成蛋白酶的活性中心;主要潜在抗原表位区域都为5个,并在第47-49aa和200-203aa区域出现了重合,但表位重合区的氨基酸种类不完全相同。应用生物信息方法预测和比较了Der f 9、Der p 9和Blo t 9结构与抗原方面的信息,为进一步研究变应原第9组分的生物学功能、疫苗研制奠定了基础。 相似文献
9.
《Life sciences》1994,54(6):PL69-PL74
The in vivo metabolism of 9-cis-retinoic acid (9-c-RA), an endogenous ligand of retinoid X receptors (RXRs), which can also bind to retinoic acid receptors (RARs), was examined in pregnant mice and rats following a single oral dose of 100 mg 9-cis- retinaldehyde (9-c-RAL) / kg body weight. 9-Cis-retinoyl-β-glucuronide (9-c-RAG), a metabolite not found in vivo before, was a major metabolite of 9-c-RA in mouse plasma and was also present in all mouse tissues examined as well as in rat plasma. In both species putative oxidation products of retinoic acids and high levels of retinyl esters were found. Concentrations of retinoic acid isomers and retinoyl-β-D-glucuronides in the mouse plasma greatly exceeded those of the rat plasma. The finding of high levels of 9-c-RAG underlines the importance of glucuronidation in the metabolism of retinoids. 相似文献
10.
《Bioscience, biotechnology, and biochemistry》2013,77(4):1032-1037
The relationship between the antibacterial activity and structure of 9-O,9′-O-demethyl (+)-virgatusin (Virg 3) was examined. The conversion of hydroxy groups on the 9 and 9′ positions to amino groups increased the activity. It was found that the 3′-methoxy group was more important for higher activity than the 4′-methoxy group on the 7′-phenyl group, and that the 3,4-methylenedioxy group on the 7-phenyl group was necessary for activity. 相似文献
11.
19.
PCSK9结构与功能 总被引:1,自引:0,他引:1
前蛋白转化酶枯草溶菌素9(PCSK9)基因属于前蛋白转化酶(PC)家族,由信号肽、前结构域、催化结构域和羧基末端结构域组成.大量研究发现,PCSK9能介导低密度脂蛋白受体(LDLR)降解,调节血浆LDL胆固醇(LDL-C)水平;而PCSK9的两类主要突变,功能获得型、功能缺失型可分别导致高胆固醇血症和低胆固醇血症. 因而研究PCSK9对相关心血管疾病的防治有重要意义. PCSK9结构特性与其生化功能密切相关,突变致使其调节胆固醇代谢的机制更为复杂.本文旨在总结PCSK9结构与功能的分子生物学特性,并指出目前研究中存在的问题,以利对PCSK9的进一步探索. 相似文献