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1.
Abstract Rats exhibit ultradian as well as circadian rhythms in activity. Short‐term activity rhythms appear to result from bouts of feeding‐related behavior interspersed with periods of quiescence. We examined the relationship of activity to feeding in 12 male Long‐Evans derived rats during ad lib and restricted feeding (RF) conditions to determine the effect of RF on both circadian and ultradian activity rhythms. By the end of 20 days of RF all animals exhibited an ultradian periodicity of approximately 12 hours. A twenty‐four hour rhythm in feeding persisted, apparently due to the rats adapting to the diurnal feeding period. General findings were that RF resulted in anticipatory activity prior to feeding and that short‐term activity fluctuations and investigations of the food bin continued during RF even though overall nocturnal activity decreased. The results suggest that male rats of this strain exhibit ultradian activity rhythms that appear to be strongly related to feeding. 相似文献
2.
Menatallah M. Mohammed Aida A. Hussein Zohour N. Ibrahim 《Biological Rhythm Research》2018,49(2):175-185
Circadian and stress systems have a crucial role in adaptation of organisms to environmental challenges. This study investigates the ability of Oscillatoria brevis (O. brevis) β-carotene extract (βC) in modulating the circadian alternations of locomotor activity (LA) and serum melatonin (M) rhythms under chronic unpredictable stress (CUS) in rats. Twenty rats (5 rats/group) were used in monitoring LA using running wheels. Eighty rats (20 rats/group) were used in observing circadian serum M profile. Rats were randomly divided into four groups, viz. control, βC-treated, CUS-exposed, and “βC-treated&CUS-exposed” groups. CUS-exposure was applied for 21 days. One hour before exposure, βC was daily administered (10 mg/kg), intraperitoneally (IP). Blood was sampled at 6-h intervals for 5 rats/time point at Zeitgeber (ZT) 3, 9, 15, and 21. Results demonstrated that unstressed rats exhibited circadian M pattern and nocturnal LA rhythm with acrophase around ZT 21 and ZT 15, respectively. CUS-exposure revealed a disturbance in these patterns. Phase shifting of M and LA profiles was recorded. A decrease M acrophase and a significant decrease in LA (p < 0.05) were recorded at ZT 9. Daily βC administration in stressed rats modulates the CRs alternation induced by CUS. It may be concluded that βC ameliorated the induced alternations in circadian rhythms. 相似文献
3.
Alan M. Rosenwasser 《Biological Rhythm Research》2013,44(2):91-96
Abstract Inbred mouse strains differ in the expression of free‐running circadian activity rhythms. Although previous studies have suggested that BALB/c mice fail to display coherent rhythmicity under constant light, these studies presented only averaged data, and not individual animals’ activity patterns. In the present study, wheel‐running activity rhythms were monitored from individual BALB/c mice during long‐term exposure to constant red light All mice displayed dramatic lability of circadian activity rhythms, characterized by spontaneous alterations in both free‐running period and rhythm coherence. These results suggest that the circadian system in this strain is composed of a population of weakly‐coupled circadian oscillators. 相似文献
4.
W. M. U. Daniels A. Jaffer V. A. Russell J. J. F. Taljaard 《Neurochemical research》1993,18(2):159-164
Bilateral injection of 6-hydroxydopamine into the medial forebrain bundle (MFB) significantly decreased monoamine concentrations in the hypothalamus. The noradrenaline and serotonin content of the paraventricular nucleus (PVN) was also significantly reduced. These drastic decreases in neurotransmitter concentration did not alter basal secretion of corticosterone. Isoproterenol. a -adrenoceptor agonist (1 mg/kg, i.p.), significantly stimulated corticosterone release in saline and MFB lesioned rats. This stimulation did not differ significantly between the two groups. Clonidine, an 2-adreceptor agonist, injected either intraperitoneally or intracerebrally just dorsal to the PVN, caused a dose-dependent increase in corticosterone secretion. The stimulation of corticosterone release by clonidine (250 g/kg, i.p.) was antagonised by the selective 2-adreceptors antagonist, yohimbine (1 mg/kg, i.p.) and significantly reduced by the MFB lesion. These results suggest that corticosterone secretion is stimulated by activation of 2-adreceptors which occur on noradrenergic nerve terminals in the PVN. 相似文献
5.
Alain E. Reinberg Marc Riedel Cedric Riedel Eric Brousse Yvan Touitou 《Chronobiology international》2017,34(8):1158-1174
Systolic (S) and diastolic (D) blood pressures (BP) [SBP and DBP] are circadian rhythmic with period (τ) in healthy persons assumed to be maintained at 24.0h. We tested this assumption in a sample of 30 healthy career (mean >12 yrs) 30-to-46 yr-old male Caucasian French firefighters (FFs) categorized into three groups according to work schedule and duties: Group A – 12 FFs working 12h day, 12h night, and occasionally 24h shifts and whose primary duties are firefighting plus paramedical and road rescue services; Group B – 9 FFs working mostly 12h day and 12h night shifts and whose duties are answering incoming emergency calls and coordinating service vehicle dispatch from fire stations with Group A personnel; Group C – 9 day shift (09:00–17:00h) FFs charged with administrative tasks. SBP and DBP, both in winter and in summer studies of the same FFs, were sampled by ambulatory BP monitoring every 1h between 06:00–23:00h and every 2h between 23:01–05:59h, respectively, their approximate off-duty wake and sleep spans, for 7 consecutive days. Activity (wrist actigraphy) was also sampled at 1-min intervals. Prominent τ of each variable was derived by a power spectrum program written for unequal-interval time series data, and between-group differences in incidence of τ≠24h of FFs were assessed by chi square test. Circadian rhythm disruption (τ≠24h) of either the SBP or DBP rhythm occurred almost exclusively in night and 24h shift FFs of Group A and B, but almost never in day shift FFs of Group C, and it was not associated with altered τ from 24.0h of the circadian activity rhythm. In summer, occurrence of τ≠24 for FFs of Group A and B differed from that for FFs of Group C in SBP (p=0.042) and DBP (p=0.015); no such differences were found in winter (p>0.10). Overall, manifestation of prominent τ≠24h of SBP or DBP time series was greater in summer than winter, 27.6% versus 16.7%, when workload of Group B FFs, i.e. number of incoming emergency telephone calls, and of Group A FFs, i.e. number of dispatches for provision of emergency services, was, respectively, two and fourfold greater and number of 12h night shifts worked by Group B FFs and number of 24h shifts worked by Group A FFs was, respectively, 92% and 25% greater. FFs of the three groups exhibited no winter-summer difference in τ≠24h of SBP or SDP; however, τ≠24h of DBP in Group B FFs was more frequent in summer than winter (p=0.046). Sleep/wake cycle disruption, sleep deprivation, emotional and physical stress, artificial light-at-night, and altered nutrient timings are hypothesized causes of τ≠24h for BP rhythms of affected Groups A and B FFs, but with unknown future health effects. 相似文献
6.
《Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie》1999,322(9):759-770
Under free-running conditions, the grey lesser mouse lemur expresses a circadian activity–rest rhythm with a period particularly short (22.50 ± 0.6 h) for a mammal. Light exerts a strong suppressive effect upon activity. After transfer from nycthemeral to free-running conditions the duration of activity was systematically increased. This extension took place in the first cycle and was characterized by both a phase advance in activity onset and an even larger phase delay in activity offset. This phenomenon was more pronounced after long day entrainment. Any shift of the light–dark cycle was followed the next day by a corresponding shift in activity onset. The phase response curve pattern was similar to that already described for nocturnal mammals. Due to the strength of light as a zeitgeber and the plasticity of the response to photic conditions, the mouse lemur appears as a convenient species for chronobiological studies on non-human primates. 相似文献
7.
Circadian rhythms of flashing and glow were recorded simultaneously in Gonyaulax polyedra by determining maximum and minimum light emission at each measured interval of 28 sec. In constant light, the two rhythms in some cases showed different period lengths (tau), the glow rhythm being up to 1 hr shorter than the flashing rhythm. Lower temperatures shortened the tau of the glow rhythm more than that of the flashing rhythm. The amplitude of the flashing rhythm decreased when the temperature was increased from 15 degrees C to 25 degrees C, whereas that of the glow rhythm was increased. These results may indicate that the two rhythms are controlled by two separate oscillators. 相似文献
8.
Locomotory and stridulatory activity rhythms of male crickets (Teleogryllus commodus) were assayed simultaneously following various experimental procedures. These included (a) severing the pathways between the ocelli and the brain, between the ommatidia and the optic lobes, or between the optic lobes and the brain, and (b) RF cauterization of the pars intercerebralis. The results indicate that (1) light-dark cycles which entrain both rhythms are perceived by the compound eyes and not by the ocelli; (2) loss of connexion between the brain and the optic lobes leads to arrhythmicity in both behaviours, but a single optic lobe can maintain rhythmicity; (3) absence of neurosecretory cells in the pars intercerebralis is correlated with loss of stridulatory activity and arrhythmicity in locomotory behaviour. It is suggested that the pars intercerebralis serves as a site of coupling between a circadian pacemaker and various overt behaviours. However, intermediate control by the pars intercerebralis is assumed to be exerted via channels that can be either hormonal or purely neuronal in nature. 相似文献
9.
Circadian rhythms of feeding, oviposition, and emergence of the boll weevil (Coleoptera: Curculionidae) 总被引:2,自引:0,他引:2
SHOIL M. GREENBERG J. SCOTT ARMSTRONG MAMOUDOUSETAMOU THOMAS W. SAPPINGTON RANDY J. COLEMAN TONG-XIAN LIU 《Insect Science》2006,13(6):461-467
Circadian rhythm of feeding, oviposition, and emergence of boll weevil adults were determined at five different photophases (24, 14, 12, 10, and 0 hours) and a constant 27℃ temperature, 65% RH in the laboratory. Squares from Petri dishes, where they were exposed to boll weevil females, were removed and examined for feeding and oviposition punctures every 4 hours during daylight (0700-1900 h) and every 12 h at night (1900-0700 h) over eight consecutive days. Cohorts of randomly selected egg-punctured squares were sampled from ovipositing females at 0700, 1100, 1500, and 1900 during 24 hours and under different photophase treatments, and maintained in Petri dishes at 27 + I℃, 65% RH. Dishes were observed twice daily (1900 and 0700 h) for adults emerging at day or night. Circadian rhythm of oviposition was not affected by the length of the photophase. The boll weevil has round-the-clock circadian rhythm of oviposition, with a daytime preference. We observed that 82.4%-86.0% of the boll weevil eggs were deposited between 0700 and 1900 h, and 14.0%-17.6% between 1900 and 0700 h during a 24-h period. Feeding of boll weevil females in photoperiods 24:0 h (complete light) and 0:24 h (complete darkness) did not significantly change between 0700-1900 h versus 1900-0700 h, while the d .ally cycle of light and darkness in other photoperiods significantly increased the feeding punctures from 0700-1900 compared with 1900-0700 h. The circadian rhythm of emergence depended significantly on the time of oviposition and the length of the photophase. Investigation of boll weevil circadian rhythm provides a better understanding of boll weevil ecology and reveals potential weak links for improving control technologies targeting their reproductive strategies. 相似文献
10.
Jonathan S. Emens Krista Yuhas Jennifer Rough Nidhi Kochar Dawn Peters Alfred J. Lewy 《Chronobiology international》2013,30(3):474-493
Differences in morningness‐eveningness among humans are commonly ascribed to circadian parameters, such as circadian period and responsivity to environmental time cues, as well as homeostatic sleep drive. Light is the primary synchronizer of the human biological clock, and if circadian differences exist between morning and evening types, they should have different phase angles of entrainment to the light/dark cycle; that is, morning and evening types should have different patterns of light exposure relative to endogenous circadian phase (ECP). When phase angle of entrainment is strictly defined as the relationship between a marker of ECP and the timing of light exposure, such differences have been demonstrated in the laboratory under controlled light/dark cycles and have recently been shown under conditions of spring and summer light exposure outside the laboratory, taking into account the variable intensity of light. Here, we report similar results from a large (n=66), diverse cohort of morning and evening types across the age span studied at all different times of the year. Differences between morning and evening types in light exposure relative to ECP, indicative of a difference in the phase angle of entrainment to the external light/dark cycle, were found. Specifically, evening types, compared to morning types, had a higher ratio of phase advancing to phase delaying by light. We interpret this as indicating a longer circadian period (τ) in evening types. 相似文献
11.
The authors define a subject as euchronic when the circadian parameters--tau (tau=period), ? (acrophse or peak time), A (amplitude), and M (MESOR=24 h rhythm-adjusted mean)--of a set of circadian variables are within the confidence limits of appropriate reference values of healthy subjects (HS). We define internal desynchronization as a state in which the circadian tau of a set of rhythms differs from 24 h and when the tau of a given variable differs from that of other variables. Such a state was first observed in singly isolated HS without access to time cues and clues. Herein, data and analyses are presented demonstrating that internal desynchronization appears to be a rather common phenomenon in HS dwelling in their natural environment (i.e., in the presence of usual zeitgebers). This has been documented by longitudinal studies (n approximately=15 days) of the circadian rhythm in sleep-wakefulness, body temperature, right- and left-hand-grip strength, and reaction time involving a total of 246 HS and 134 shift workers (SW), with 45.5% showing good and 54.5% poor SW tolerance. The presence of internal desynchronization observed in SW was associated SW intolerance, with symptoms being sleep alteration/disturbances, sleeping-pill dependence, persisting fatigue (asthenia), mood alteration, and digestive complaints. Internal desynchronization was also documented in groups of HS and tolerant SW, though it was almost the rule among the intolerant SW. The authors introduce two new terms: allochronism to describe the time organization of those SW who evidence internal desynchronization without detectable clinical symptoms, and dyschronism to describe the time organization of those SW who exhibit internal desynchrobization plus the symptoms of SW intolerance or medical illness. The condition of allochronism is not restricted only to SW tolerance, as it was detected in 112 HS without medical complains when exposed to various experimental conditions, including medications and placebos, sojourn in the high Arctic summer, intensive sport training, and task-loaded cognitive performance testing. Dyschronism in SW who are sleep-deprived is associated with persisting fatigue. An unpublished Gallup survey found that 47% of 2478 respondents experienced a state of asthenia during the previous 12 months, with symptoms mimicking those of SW intolerance. In one-third of the cases, the origin of the asthenia was undetermined. Taking into account the high incidence of internal desynchronization found in past investigations and the clinical observation that sleep deprivation is a consequence of many acute and chronic medical conditions (nocturnal pain, nocturnal asthma, etc.), it is suggested that dyschronism may be responsible for the asthenia of unknown origin, at least for some persons. The interindividual (including sex-related) variability in the propensity to exhibit an altered temporal organization, whether it be transient or persistent (i.e., reversible or non-reversible) suggests the involvement of genetic factors. The Dian-Circadian genetic model previously proposed by the authors seems pertinent to conceptualize and explain the various levels and output of internal desynchronization. 相似文献
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13.
Liang-fu Tseng Horace H. Loh Choh Hao Li 《Biochemical and biophysical research communications》1977,74(2):390-396
Human β-endorphin produced a potent antinociceptive response as estimated by the tail-flick test in rats after intraventricular injection. On a molar basis, the peptide was 21 times more potent than morphine and in addition, the peptide produced morphine-like catatonia and hypothermia. These responses were blocked by naloxone. Repeated injections of the peptide induced tolerance to analgesic response, catatonia and hypothermia. Cross tolerance to morphine was also observed. 相似文献
14.
The study aimed to determine the influence of repeated natural dawn and dusk twilight pulses in entraining the circadian flight activity rhythm of the microchiropteran bat, Hipposideros speoris, free‐running in constant darkness in a natural cave. The bats were exposed to repeated dawn or dusk twilight pulses at eight circadian phases. All bats exposed to dawn twilight pulses were entrained by advancing transients, and the stable entrainment was reached when the onset of activity occurred about 12 h before the lights‐on of the pulses, irrespective of the initial phase at which the bats were exposed to twilight. All bats exposed to dusk twilight pulses, however, were entrained by delaying transients, and the stable entrainment was reached when the onset of activity occurred about 1.6 h after the lights‐on of the pulses. The entrainment caused by dawn and dusk twilight pulses is discussed in the context of the postulated two photoreceptors: the short wavelength sensitive (S) photoreceptors mediating entrainment via dusk twilight, and the medium wavelength sensitive (M) photoreceptors mediating entrainment via dawn twilight. 相似文献
15.
Song-yan Liu Ti-yuan Li Zhitao Zhao Ricky Y. K. Man Fan Wang 《Molecular and cellular biochemistry》1994,132(2):109-115
Previous studies have shown the pathogenic effects of grains cultivated in the endemic areas of Keshan disease and selenium is effective in the prevention of this disease. In this study, liver damages induced by feeding grains from an endemic area (endemic diet), and the effects of selenium and -tocopherol supplement were examined. After 3 months on the endemic diet, the amounts of serum enzymes were significantly increased when compared to controls (animals receiving diet from a non-endemic area). Liver enzymes (alkaline phosphatase and choline esterase) were also found to be altered in the serum, further suggesting liver damages in animals on an endemic diet. Supplement of the endemic diet with selenium or -tocopherol reversed the changes in serum enzymes. Increase in lipid peroxidation in the liver of animals on the endemic diet was observed when compared to that in control animals. Selenium and -tocopherol supplements prevented the increase in lipid peroxidation in the liver by the endemic diet. Semi-quantitative histochemical analysis of glutamate dehydrogenase and succinate dehydrogenase in liver tissue showed that the livers of animals on an endemic diet were more sensitive to ischemic damagesin vitro. Supplementation of the endemic diet with either selenium or -tocopherol reduced the sensitivity to ischemic damages. The results suggest that increased lipid peroxidation in the liver of rats on an endemic diet may be responsible for liver damages and elevation of serum enzymes. Restoration of glutathione peroxidase activity by selenium supplement or an increase in the content of -tocopherol in the liver can prevent lipid peroxidation in animals on an endemic diet and thus provide the protective effects against liver damages. 相似文献
16.
Mohammad Askar Bhanot Sanjay McNeill John H. 《Molecular and cellular biochemistry》2001,223(1-2):103-108
The PI3 kinase signalling pathway is an important pathway in mediating the glucoregulatory effects of insulin and skeletal muscle (SKM) is the major tissue involved in glucose utilization. In diabetes this pathway is impaired, either due to lack of insulin as in Type 1 diabetes, or due to insulin resistance as in Type 2 diabetes. Bis(maltolato)oxovanadium IV (BMOV), an insulin mimetic/enhancing agent, produces a marked glucose lowering effect in models of both types of diabetes. Some in vitro studies have shown that phosphatidylinositol 3 kinase (PI3 kinase) activity is enhanced by vanadium. In the present study we looked at changes in PI3 kinase expression and activity in SKM from STZdiabetic and fa/fa Zucker rats treated with BMOV for 3 weeks. Although BMOV treatment completely normalized glucose levels in STZdiabetic rats, no effect was observed on basal or insulin-stimulated PI3 kinase activity. In fatty Zucker rats, activation of PI3 kinase activity after insulin injection was impaired as compared to age matched lean controls, but BMOV again did not affect the activity. These results suggest that although PI3 kinase is an important signalling factor in glucose utilization, vanadium treatment does not reduce hyperglycemia through activation of SKM PI3 kinase in vivo. 相似文献
17.
Gerard J. Boer Henriëtte A. Griffioen Hans Duindam Tjitske P. van der Woude Wop J. Rietveld 《Biological Rhythm Research》2013,44(2):118-136
Summary Suprachiasmatic nucleus (SCN)‐lesioned rats which had received a fetal SCN graft were kept in constant red light for three months. After this period it was examined whether those rats that showed a recovered free‐running circadian rhythm could be entrained to light/dark cycles. To this end, they were subjected to a 12 h light/12 h dark schedule, followed by a 12 h light shift and again to dark conditions. In addition, the same regime was imposed on SCN‐grafted rats without recovered circadian rhythms and on sham‐grafted animals with a lesion, which were studied as controls. The presence of an SCN graft was identified immunocytochemically by the presence of vasopressin, vasoactive intestinal polypeptide and somatostatin cells. Drinking, eating and wheel‐running rhythms were found to synchronize to the light/dark cycles in all rats, not with standing the presence of an SCN graft was. A 12 h light shift was immediately followed by a shift in the three rhythms. Under final dark conditions, free‐running patterns reappeared in rhythm‐recovered animals, without any convincing evidence for entrainment of the rhythms in the pattern of transition. Behavioral rhythms in SCN‐lesioned rats are apparently masked by 12 h light/dark schedules via other visual pathways than the direct projection from the retina to the SCN. 相似文献
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Abstract The circadian rhythms of blood pressure (BP) and heart rate (HR) were documented in 30 patients for a 24‐hour period before and during the 24 hours that included unilateral surgery for senile cataract or retinal detachment. The patients were premedicated with diazepam. Anaesthesia was induced at a fixed time (09.00) in all patients with thiopentone, and muscle relaxation was with pancuronium. Maintenance was with enflurane in 15 patients and with fentanyl and droperidol in the rest. Though the intraoperative changes in haemodynamic parameters were dissimilar with the two types of maintenance agents, but both types had a similar effect on the circadian rhythms of blood pressure and heart rate. Whereas preoperatively the BP and HR circadian rhythms were nearly in phase, with their peaks in the late morning to early afternoon, the postoperative rhythms underwent a dissociation to a phase shift in the BP 24‐h pattern. The phase effect may be hypothetically attributed to direct pharmacological actions or to masking effects. 相似文献
20.
Processes involved in the operation of the circadian pacemaker are well characterized; however; little is known about what mechanisms drive the overt diurnal, nocturnal, or crepuscular behavior in a species. In this context, dual‐phasing rodents, such as Octodon degus, emerge as a useful model to decipher these keys. Two main chronotypes, nocturnal and diurnal, have been traditionally described in laboratory‐housed degus based on the percentage of activity displayed by the animals during the scotophase or photophase. However, if one considers also the entrainment phase angle during the first days following a change from LD to DD conditions, a third chronotype (intermediate)—or more properly, a continuous grading of circadian expressions between diurnal and nocturnal chronotype—can be observed. Our experiments suggest the pacemaker of the diurnal animal is entrained to the photophase, and light does not exert a negative masking effect. The pacemaker of the nocturnal degus, on the other hand, is entrained to the scotophase, and light exerts a strong negative masking effect. Finally, the intermediate chronotype is characterized by variable negative masking effect of light overlapping a pacemaker entrained to the photophase. The phase shift inversion from diurnal to nocturnal chronotype is related to the availability of a wheel in the cage, and the effect may be located downstream from the clock. However, body temperature rhythm recordings, less affected by masking effects, point to an involvement of the circadian pacemaker in chronotype differentiation, as transient entrainment cycles, and not an abrupt phase shift, were detected after providing access to the wheel. The diurnality of degus seems to be the result of a variety of mechanisms, which may explain how different processes can lead to similar chronotypes. 相似文献