共查询到20条相似文献,搜索用时 15 毫秒
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《Electronic Notes in Theoretical Computer Science》1995,96(1):1-5
Multichannel recordings of visual evoked potentials (VEPs) have proved to be useful in the evaluation of visual field defects. We studied the topographic distribution of transient VEPs in 15 migraine patients (8 with visual aura and 7 without) and 15 age-matched controls during the migraine-free interval. All the subjects included in the study had normal visual fields. VEPs were recorded from 9 electrodes placed on the posterior scalp. Stimuli were full-field and hemifield reversing square wave grating patterns of medium spatial frequency (4 c/deg). The groups did not show significant differences in latencies and amplitudes of the major components (N70, P100) recorded from the midline. However, migraine patients with visual hemianopic aura showed definite asymmetries in the VEP amplitude distribution. Significantly reduced, absent or polarity-invered VEP responses were recorded ipsilateral to the side of the prodromic visual symptoms. Direct comparison of affected and unaffected hemispheres by partial field stimulation confirmed these findings. According to the VEP cortical generator theory, these abnormalities suggest a functional anomaly consistent with the clinical syndrome and detectable also in the migraine-free interval. None of the migraine patients without aura or the controls showed VEP amplitude asymmetries. We conclude that multichannel VEP recordings may discriminate between different subtypes of migraine and contribute important physiopathological information to the study of this disease. 相似文献
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N. L. Pisareva 《Neurophysiology》1974,6(5):389-394
Evoked potentials arising in the visual cortex and superior colliculus to stimulation of the collateral eye by single, paired, and repetitive flashes were recorded in rabbits reared in darkness or in normal illumination. The absence of significant change in the latent period and amplitudes of the first two components of the collicular responses and of the recovery cycle and response to repetitive stimulation in the light-deprived animals suggest that photic stimulation does not affect the normal functional development of the rabbit retinotectal system. However, functional deafferentation in the early postnatal period gives rise to serious disturbances of visual cortical function, as reflected in a marked decrease in amplitude of the primary response, lengthening of the recovery cycle, and narrowing of the range of rhythm-binding frequencies of flashes. These disturbances were reversible. The period of maximal sensitivity of the rabbit retinocortical system to visual deprivation begins at the end of the first month of postnatal life. The possible mechanisms lying at the basis of these functional disturbances in light-deprived animals are discussed. 相似文献
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《Electronic Notes in Theoretical Computer Science》1987,68(3):161-171
Pattern-electroretinograms (P-ERGs) and visual evoked potentials (VEPs) were simulataneously recorded in 112 normal individuals aged 20–75. Two sized checks subtending 15′ and 31′ were used as stimuli. A weighted regression analysis was used to determine which of the variables, sex or age, was significant. The latency of the a and b wave of the P-ERGs showed a progressive increase with age but no difference between sexes. The effect was statistically significant for both 15′ and 31′ checks. There was no statistically significant aging effects for VEPs elicited by 31′ checks. Aging, however, affected N70, P100, and the interpeak interval between b wave to N70 and b wave to P100 for responses to 15′ checks. Shorter VEP latencies were noted in females for both 15′ and 31′ checks.The simultaneous recording of P-ERGs and VEPs has demonstrated that aging is a major variable at the retinal level. The effects on the a and b waves are mostly due to optic changes with aging and only partially to aging changes in the neuronal retinal circuitry. The effect of aging on VEPs is different for different size stimuli. The cause is a random neuronal cell loss in the visual pathways from the optic nerve to the visual cortex as the individual ages.The difference in VEP data between sexes may be related to anatomical size and hormonal influences. 相似文献
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I Czigler 《Activitas nervosa superior》1979,21(2):81-89
Visual evoked potentials to patterned stimulation of the upper and lower half of the visual field were investigated in nine adult Ss. The inter-stimulus interval varied between 350 and 2,600 msec. With patterned stimulation, no inter-stimulus interval effects were obtained for occipital components. In contrast for the vertex lead, on the other hand, as inter-stimulus interval increased, the N140-P200 amplitude increased. Because of the heterogeneity subjects' responses evoked by upper half-field stimulation, this effect was more pronounced in lower half-field stimulation. 相似文献
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I A Shimko 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》1984,34(1):124-128
The influence of long-term (3 months) locomotor deprivation of rats in a month age, on the evoked potentials (EP) of the sensorimotor and the visual cortex was studied in conditions of presentation of single and paired stimuli. Changes were revealed in both cortical zones. An increase of peak latency of the initial positive EP phase in the sensorimotor cortex, and prolongation of the process of changes in excitability of neural elements, elicited by conditioning stimulus, was revealed both in the sensorimotor and the visual areas. The effect of deprivation on the dynamics of changes in neuronal systems excitability was greater in the visual evoked responses. 相似文献
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《Electronic Notes in Theoretical Computer Science》1984,59(2):125-133
VEPs to checkerboard pattern-reversal were recorded from 18 epileptic patients who had EEG photoparoxysmal responses to stroboscopic light. Patients were grouped according to whether seizures were precipitated by environmental light stimuli, or television viewing. Longitudinal studies were conducted on 8 patients treated with valproic acid. We concluded the following: (1) Latency of the major positive peak (P2) of the pattern-reversal VEP was shorter among photosensitive patients than among normal controls. This was especially true of television-sensitive patients. (2) Valproic acid, when effective in controlling seizures, lengthened the P2 latency and decreased VEP amplitude. Studies of drug effects on VEPs may help to elucidate neurochemical mechanisms of the visual cortex. (3) Because of overlap of values with normals, VEP measurements are not at present very sensitive in the diagnosis of photosensitivity. However, longitudinal studies in individuals parallel clinical changes and may be useful as objective measures of improvement. 相似文献
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Kozlovskiĭ SA Vartanov AV 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》2000,50(4):638-646
Changes in human EEG and event-related potentials to the complex color stimulus were studied during performance of three cognitive tasks: passive viewing, visual searching, and memorizing and storing of the stimulus in the operative memory. It was shown that involvement of memory mechanisms resulted in the alpha rhythm suppression in both occipital and frontal brain areas. It was also accompanied by a generation of the slow positive component in the evoked potential recorded in the frontal areas (in the occipital areas this wave was manifested as negative). 相似文献
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Kharauzov AK Pronin SV Sobolev AF Koskin SA Boĭko EV Shelepin IuE 《Rossi?skii fiziologicheski? zhurnal imeni I.M. Sechenova / Rossi?skaia akademiia nauk》2005,91(8):956-969
Electrophysiological measurements of the threshold spatial frequency were conducted in 26 healthy subjects by using visual evoked potentials with the purpose of objective determination of the visual acuity. For that we proposed a universal method of the visual stimulation and EEG processing (using ICA decomposition in particular) to minimize errors arising on account of individual differences in the visual system functioning. As a result, a correlation of 0.74 and a logarithmic dependence were obtained between spatial resolution measured by electrophysiological and psychophysical methods. The proposed methods of objective measurement of visual resolution has a high effectiveness, does not depend on specificity of individual EEG and domination of different channels in the visual system. Therefore it is possible to determinate objectively the visual acuity in humans independently of their responses. 相似文献
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Steroid dependent changes in human visual evoked potentials 总被引:2,自引:0,他引:2
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Maturation of ERG and evoked visual potentials in mice 总被引:1,自引:0,他引:1
N Bonaventure P Karli 《Comptes rendus des séances de la Société de biologie et de ses filiales》1968,162(2):553-555
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Shevelev IA Mikhaĭlova ES Kulikov MA Slavutskaia AV 《Zhurnal vysshe? nervno? deiatelnosti imeni I P Pavlova》2008,58(2):151-162
3D tracing of equivalent current dipoles (ECDs) of averaged human visual evoked potentials (VEP) by their distribution across a 34-electrode array was obtained under short presentation of pattern-onset stimuli (sets of 45 horizontal, vertical bars or crosses). Using a 2-dipole spherical three-layer model, we dynamically (step of 1 ms) localized dipoles in four healthy subjects. Dipole locations were matched to anatomical brain regions visualized in structural MRI. Best-fitting source parameters were superimposed on MR images of each subject to identify the anatomical structures giving rise to the surface patterns. It was found that during 50-300 ms following the onset of the stimuli, the ECDs in all subjects were localized in the occipital cortex and demonstrated reliable systematic shift in localization. Two local (1-2 cm3) zones of the preferable dipole attendance were found at 5-6 cm behind zero line: the first one was localized near the midline of the brain, whereas the other zone was situated in the right hemisphere at a distance of 6-7 cm from the first zone. Their localization and strength of activation were reliably different for crosses and lines and changed during VEP generation. Zones of relatively rare dipole attendance were found also. The data are discussed in relation to localization of initial and endpoint of ECDs trajectories, as well as with sensitivity of the visual cortex to line crossing and branching. 相似文献
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Experiments on cats showed that complete operative exclusion of the reticular formation by precollicular section prevents the development of habituation of evoked potentials in the primary visual projection area and lateral geniculate body. Similar results were obtained after postcollicular section of the mesencephalon. The phenomenon of habituation of visual evoked potentials is found in posttrigeminal preparations. It is postulated that the tonic inhibitory division of the reticular formation plays an important role in the development of the habituation phenomenon.Odessa State Medical Institute. Translated from Neirofiziologiya, Vol. 4, No. 5, pp. 540–544, September–October, 1972. 相似文献
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The independent component analysis was applied to multichannel transient visual evoked potentials elicited by a high contrast pattern-reversal and motion-onset (motion velocity of 7 and 23 deg/s). Three overlapping independent components with different topographical distribution over the scalp were described. The first component displayed similar timing in response to all three stimuli (40-200 ms) but was a different in shape and scalp projection. This activation component is considered to reflect the stimulus properties. The second component (100-227 ms), related to negativity at about 160 ms, can be referred to visual processing of motion. The last component, attributed to positivity at 230 ms dominates in the fronto-central area and might represent a cognitive process. 相似文献
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In a complex choice reaction time experiment, patterned stimuli without luminance change were presented, and pattern-specific visual evoked potentials to lower half-field stimulation were recorded. Two experimental conditions were used. The first was the between-field selection, where square patterns were presented in either the lower or the upper half of the visual field. In a given stimulus run one of the half-fields was task-relevant, and the subjects' task was to press a microswitch to stimuli of higher duration value (GO stimuli), while they had to ignore shorter ones, i. e. stimuli of lower apparent spatial contrast (NOGO stimuli). They had to ignore the stimuli appearing in the irrelevant half-field (IRR stimuli). In order to ensure proper fixation, the subjects had to press another microswitch at the onset of a dim light at the fixation point (CRT stimuli). Our second experimental condition was the within-field selection, where the GO, NOGO, and IRR stimuli appeared in the lower half of the visual field. GO and NOGO were square patterns while IRR stimuli were constructed of circles, or vice versa. (The CRT stimuli were the same as in the previous condition.) Three pattern-specific visual evoked potential components were identified, i. e. CI (70 ms latency), CII (100 ms latency), and CIII (170 ms latency). There were marked selective attention effects on both the CI-CII and CII-CIII peak-to-peak amplitudes. In both experimental conditions, responses with the highest amplitude were evoked by the GO type of stimuli, while the IRR stimuli evoked the smallest responses. According to these results, attention effects on the pattern-specific visual evoked potentials in the first 200 ms cannot be attributed to a simple stimulus set kind of selection. 相似文献
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Soragna D Vettori A Carraro G Marchioni E Vazza G Bellini S Tupler R Savoldi F Mostacciuolo ML 《American journal of human genetics》2003,72(1):161-167
Migraine is a common and disabling neurological disease of unknown origin characterized by a remarkable clinical variability. It shows strong familial aggregation, suggesting that genetic factors are involved in its pathogenesis. Different approaches have been used to elucidate this hereditary component, but a unique transmission model and causative gene(s) have not yet been identified. We report clinical and molecular data from a large Italian pedigree in which migraine without aura (MO) segregates as an autosomal dominant trait. After exclusion of any association between MO and the known familial hemiplegic migraine and migraine with aura loci, we performed a genomewide linkage analysis using 482 polymorphic microsatellite markers. We obtained significant evidence of linkage between the MO phenotype and the marker D14S978 on 14q22.1 (maximum two-point LOD score of 3.70, at a recombination fraction of 0.01). Multipoint parametric analysis (maximum LOD score of 5.25 between markers D14S976 and D14S978) and haplotype construction showed strong evidence of linkage in a region of 10 cM flanked by markers D14S1027 and D14S980 on chromosome 14q21.2-q22.3. These results indicate the first evidence of a genetic locus associated with MO on chromosome 14. 相似文献