共查询到20条相似文献,搜索用时 31 毫秒
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An alternative, human SRC promoter and its regulation by hepatic nuclear factor-1alpha 总被引:2,自引:0,他引:2
Bonham K Ritchie SA Dehm SM Snyder K Boyd FM 《The Journal of biological chemistry》2000,275(48):37604-37611
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Boudreau F Rings EH van Wering HM Kim RK Swain GP Krasinski SD Moffett J Grand RJ Suh ER Traber PG 《The Journal of biological chemistry》2002,277(35):31909-31917
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Hirokane H Nakahara M Tachibana S Shimizu M Sato R 《The Journal of biological chemistry》2004,279(44):45685-45692
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Tarumi T Kravtsov DV Zhao M Williams SM Gailani D 《The Journal of biological chemistry》2002,277(21):18510-18516
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Apolipoprotein A-IV (apoA-IV) is a 46 kDa glycoprotein that associates with triglyceride-rich and high density lipoproteins. Blood levels of apoA-IV generally correlate with triglyceride levels and are increased in diabetic patients. This study investigated the mechanisms regulating the in vivo expression of apoA-IV in the liver and intestine of mice in response to changes in nutritional status. Fasting markedly increased liver and ileal apoA-IV mRNA and plasma protein concentrations. This induction was associated with increased serum glucocorticoid levels and was abolished by adrenalectomy. Treatment with dexamethasone increased apoA-IV expression in adrenalectomized mice. Marked increases of apoA-IV expression were also observed in two murine models of diabetes. Reporter gene analysis of the murine and human apoA-IV/C-III promoters revealed a conserved cooperative activation by the hepatic nuclear factor-4 alpha (HNF-4 alpha) and the peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1 alpha) but no evidence of a direct regulatory role for the glucocorticoid receptor. Consistent with these in vitro data, induction of apoA-IV in response to fasting was accompanied by increases in HNF-4 alpha and PGC-1 alpha expression and was abolished in liver-specific HNF-4 alpha-deficient mice. Together, these results indicate that the induction of apoA-IV expression in fasting and diabetes likely involves PGC-1 alpha-mediated coactivation of HNF-4 alpha in addition to glucocorticoid-dependent actions. 相似文献