A chronic implant for recording of cochlear potentials in primates

A new technique for the continuous recording of peripheral bioelectrical activity in the auditory system of primates is described. Because of basic differences in the anatomy of the temporal bone, the approach to the round window of the cochlea is more difficult in most primates than in lower animals. A relatively simple surgical approach, which made possible the placement of an electrode into the perilymph of the inner ear via the well-demarcated horizontal semicircular canal was therefore developed and is described in detail. The bared tip of a Teflon-coated wire was cemented into the canal opening with carboxylate cement, and the wire attached to a permanent electrical connector on the skull. Cochlear microphonic and action potentials of 50 to 100 μV amplitude were thus recorded on a continuing basis at the same time that behavioral studies of primate auditory acuity were conducted.     

人工耳蜗植入聋儿术前基因检测及家系分析

摘要: 国内外研究表明GJB2、SLC26A4(PDS)和线粒体DNA(Mitochondrial DNA, mtDNA)的病理性突变导致了大部分的遗传性聋。 文章收集了2006年4月~2007年9月接受人工耳蜗(Cochlear implant, CI)植入的14 例患儿及其父母的外周血, 应用基因诊断方法进行 GJB2、SLC26A4(PDS)和mtDNA 1555位点突变检测。结果显示, 35.7%的患儿检测到致病突变, 其中28.6%为GJB2基因突变, 类型均为235delC纯和突变, 其父母为携带GJB2 235delC的杂和子; 7.1%为mtDNA A1555G突变, 其母亲亦携带mtDNA A1555G突变。这表明CI 植入聋儿最常见的基因突变是GJB2 235delC突变, 其次是mtDNA A1555G突变, 通过对耳聋家系常见致病基因的检测和家系分析, 可以对优生优育及减少耳聋发病率提供科学准确的遗传信息。     

Audiovisual Reviews

Book reviewed in this article:
Television Productions: Teacher's Guide, anonymous, no date, 16 pp. Free from Time-Life Multimedia. The Tribal Eye, David Attenborough
Television Productions: The Tribal Eye, David Attenborough     

Audiovisual Notes

Growing Up at Paradisc. 1977 . By Sundy Wilson .
Mbindo Lala: a Hospital in Village Form . 1976.     

Audiovisual Review

Book reviewed in this article:
Films: St-Pascal . 1972. A University of Guelph Production. Raymond Pollard
Films: Pour la suite du monde . 1963. Produced by the National Film Board of Canada. Pierre Perrault
Films: Le règne du jour . 1966. Produced by the National Film Board of Canada. Pierre Perrault     

Audiovisual Books

Book reviewed in this article:
The Inuit Print/L'estampe inuit . Helga Goetz.
Pitseolak: Pictures Out of My Life . Dorothy Eber     

Spatio-temporal source modeling of evoked potentials to acoustic and cochlear implant stimulation

Spatio-temporal source modeling (STSM) of event-related potentials was used to estimate the loci and characteristics of cortical activity evoked by acoustic stimulation in normal hearing subjects and by electrical stimulation in cochlear implant (CI) subjects. In both groups of subjects, source solutions obtained for the N₁/P₂ complex were located in the superior half of the temporal lobe in the head model. Results indicate that it may be possible to determine whether stimulation of different implant channels activates different regions of cochleotopically organized auditory cortex. Auditory system activation can be assessed further by examining the characteristics of the source wave forms. For example, subjects whose cochlear implants provided auditory sensations and normal hearing subjects had similar source activity. In contrast, a subject in whom implant activation evoked eyelid movements exhibited different source wave forms. STSM analysis may provide an electrophysiological technique for guiding rehabilitation programs based on the capabilities of the individual implant user and for disentangling the complex response patterns to electrical stimulation of the brain.     

A new stimulation strategy for recording electrical auditory evoked potentials in cochlear implant patients

Recording electrical auditory brainstem responses (EABR) provides clinical insight about responses of the residual post-cochlear neural system to electrical stimulation in profoundly deaf patients. A new strategy is presented for stimulating patients already implanted with a 15-electrode cochlear implant. Since the device is fully re-programmable via a RS-232 PC interface, it was possible to load a specific stimulating strategy designed to improve the spatial locus and the temporal structure of the impulse stimulation. Waves III to V emerge more clearly when this method is applied.     

Hysteresis in Audiovisual Synchrony Perception

The effect of stimulation history on the perception of a current event can yield two opposite effects, namely: adaptation or hysteresis. The perception of the current event thus goes in the opposite or in the same direction as prior stimulation, respectively. In audiovisual (AV) synchrony perception, adaptation effects have primarily been reported. Here, we tested if perceptual hysteresis could also be observed over adaptation in AV timing perception by varying different experimental conditions. Participants were asked to judge the synchrony of the last (test) stimulus of an AV sequence with either constant or gradually changing AV intervals (constant and dynamic condition, respectively). The onset timing of the test stimulus could be cued or not (prospective vs. retrospective condition, respectively). We observed hysteretic effects for AV synchrony judgments in the retrospective condition that were independent of the constant or dynamic nature of the adapted stimuli; these effects disappeared in the prospective condition. The present findings suggest that knowing when to estimate a stimulus property has a crucial impact on perceptual simultaneity judgments. Our results extend beyond AV timing perception, and have strong implications regarding the comparative study of hysteresis and adaptation phenomena.     

Determination of frictional conditions between electrode array and endosteum lining for use in cochlear implant models

Frictional conditions between the electrode array (in cochlear implants) and the endosteum lining covering the walls of the interior scala tympani structure strongly influence the sliding behaviour of the electrode array. Friction coefficients, determined by a simple but effective method based on the impending slippage model of electrode arrays sliding over the endosteum lining are reported in this paper. In this study, friction coefficients of the Nucleus standard straight and the Contour arrays have been determined with and without lubricants applied on the endosteum lining. In the absence of applied lubricants, friction coefficients were found to be 0.19 for the Nucleus standard straight array and 0.12 for the Contour array. Application of lubricants (glycerin and sorbelene) has the potential to lower the friction coefficient for Nucleus standard straight array (0.12 and 0.15) and for the Contour array (0.04 and 0.08). These results are used in finite element models to predict accurately the trajectories of electrode arrays and sliding contact pressures on cochlear structures to evaluate the likelihood of damage sustained during insertion.     

The Audiovisual Tau Effect in Infancy

Background

Perceived spatial intervals between successive flashes can be distorted by varying the temporal intervals between them (the “tau effect”). A previous study showed that a tau effect for visual flashes could be induced when they were accompanied by auditory beeps with varied temporal intervals (an audiovisual tau effect).

Methodology/Principal Findings

We conducted two experiments to investigate whether the audiovisual tau effect occurs in infancy. Forty-eight infants aged 5–8 months took part in this study. In Experiment 1, infants were familiarized with audiovisual stimuli consisting of three pairs of two flashes and three beeps. The onsets of the first and third pairs of flashes were respectively matched to those of the first and third beeps. The onset of the second pair of flashes was separated from that of the second beep by 150 ms. Following the familiarization phase, infants were exposed to a test stimulus composed of two vertical arrays of three static flashes with different spatial intervals. We hypothesized that if the audiovisual tau effect occurred in infancy then infants would preferentially look at the flash array with spatial intervals that would be expected to be different from the perceived spatial intervals between flashes they were exposed to in the familiarization phase. The results of Experiment 1 supported this hypothesis. In Experiment 2, the first and third beeps were removed from the familiarization stimuli, resulting in the disappearance of the audiovisual tau effect. This indicates that the modulation of temporal intervals among flashes by beeps was essential for the audiovisual tau effect to occur (Experiment 2).

Conclusions/Significance

These results suggest that the cross-modal processing that underlies the audiovisual tau effect occurs even in early infancy. In particular, the results indicate that audiovisual modulation of temporal intervals emerges by 5–8 months of age.     

Some New Audiovisual Catalogues

Book reviewed in this article:
Films, The Visualization of Anthropology . Lori A. Baldwin, M. Kathleen Duttro , and Geza Teleki , eds.
The World of Islam, Images and Echoes: A Critical Guide to Films and Recordings . Ellen-Fairbanks Bodman , gen ed.
Media Log. A Guide to Television, Film and Radio Programs Supported by the National Endowment for the Humanities . Lilian Jimenez, Mara Mayor , and Virginia Schofield , eds.
Encyclopaedia Cinematographica: Cultural Anthropology Catalog . Richard Lytle and John K. Mallory , compilers.
Films from D.E.R . Toby Alice Volkman
Native Americans on Film and Video . Elizabeth Weatherford , ed.     

A phenomenological computational model of the evoked action potential fitted to human cochlear implant responses

There is a growing interest in biomedical engineering in developing procedures that provide accurate simulations of the neural response to electrical stimulus produced by implants. Moreover, recent research focuses on models that take into account individual patient characteristics.We present a phenomenological computational model that is customized with the patient’s data provided by the electrically evoked compound action potential (ECAP) for simulating the neural response to electrical stimulus produced by the electrodes of cochlear implants (CIs). The model links the input currents of the electrodes to the simulated ECAP.Potentials and currents are calculated by solving the quasi-static approximation of the Maxwell equations with the finite element method (FEM). In ECAPs recording, an active electrode generates a current that elicits action potentials in the surrounding auditory nerve fibers (ANFs). The sum of these action potentials is registered by other nearby electrode. Our computational model emulates this phenomenon introducing a set of line current sources replacing the ANFs by a set of virtual neurons (VNs). To fit the ECAP amplitudes we assign a suitable weight to each VN related with the probability of an ANF to be excited. This probability is expressed by a cumulative beta distribution parameterized by two shape parameters that are calculated by means of a differential evolution algorithm (DE). Being the weights function of the current density, any change in the design of the CI affecting the current density produces changes in the weights and, therefore, in the simulated ECAP, which confers to our model a predictive capacity.The results of the validation with ECAP data from two patients are presented, achieving a satisfactory fit of the experimental data with those provided by the proposed computational model.