Deoxyribonuclease I (DNase I)

A number of phosphodiesterases, some of which possess additional biological activities (e.g., antitumor, immunosupressive, and so on), have been considered for use in targeted tumor therapy. We propose Deoxyribonuclease I (DNase I), a compact, monomeric enzyme, as a very attractive candidate for targeting to tumor cells. Only a small amount of enzyme targeted to a cell needs to enter the nucleus in order to degrade the chromosomal DNA, making a cell incapable of further replication. We describe preliminary data on the construction of a potent single-chain antibody (scFv) immunotoxin based on bovine pancreatic DNase I. The use of a mammalian enzyme should be much less toxic and less immunogenic than current immunotoxins and may expand the current limits of immunotoxin therapy.     

I Shop, Therefore I Am

The Shopping Experience. Pasi Folk and Colin Campbell eds. London: Sage, 1997. 212 pp.
. Theory of Shopping. Daniel Miller. Ithaca, NY: Cornell University Press, 1998. 180 pp.
Shopping, Place and Identity. Daniel Miller. Peter Jackson. Nigel Thrift. Beverly Holbrook. and Michael Rowlands. London: Routledge, 1998. 214 pp.     

I am what I eat and I eat what I am: acquisition of bacterial genes by giant viruses

Giant viruses are nucleocytoplasmic large DNA viruses (NCLDVs) that infect algae (phycodnaviruses) and amoebae (Mimivirus). We report an unexpected abundance in these giant viruses of islands of bacterial-type genes, including apparently intact prokaryotic mobile genetic elements, and hypothesize that NCLDV genomes undergo successive accretions of bacterial genes. The viruses could acquire bacterial genes within their bacteria-feeding eukaryotic hosts, and we suggest that such acquisition is driven by the intimate coupling of recombination and replication in NCLDVs.     

I. I. Mechnikoff's contribution to immunology

I. I. Mechnikoff's contribution to various aspects of immunology is evaluated. The 25 years' struggle of this scientist for the existence of phagocytosis theory is briefly described. Works of I. I. Mechnikoff dealing with several factors of humoral immunity and cytotoxins are reviewed. The significance of I. I. Mechnikoff's studies providing analysis of immune processes in the phylogenetic sense as well as his ideas about the nervous system role in immunity processes is stressed.     

Digitalisstudien I

Ohne ZusammenfassungMit 6 Textfiguren und 4 Tafeln.     

Ophryotrocha-Studien I

Ohne Zusammenfassung