Peptoids belong to a class of sequence-controlled polymers containing N-alkylglycine units. Ren et al. use tandem mass spectrometry to characterize the fragmentation patterns of some singly and doubly protonated peptoids with one basic residue at different positions. Upon collision-induced dissociation, a charged peptoid dissociates into two sets of charged fragments: B-ions, containing the N-terminal residue (structure on the left); and Y-ions, containing the C-terminal residue (structure on the right). The Y-ions are of higher abundance than the B-ions, revealing that the C-terminal fragments have a higher affinity toward the charge carrier, the proton. (DOI: 10.1002/bip.23358 )
Probing amyloid formation of intrinsically disordered proteins (IDPs) in aqueous solutions with ionic liquids (ILs) could help identify the IL–IDP interactions causing the process in this media. Takekiyo et al. report that ethylammonium nitrate (EAN) initiates the formation of intermolecular β-sheet structure – amyloid-like aggregates – of α-synuclein. The cations and anions of EAN function as charges to mask side chains, leading to the formation of a polyproline II helix that assists the formation of α-synuclein aggregates. The present results could help develop promoting agents for amyloid aggregates in biomaterials science. (DOI: 10.1002/bip.23352)
A novel volumetric information fusion based on joint weighted evaluation and stationary wavelet transform is proposed. Threedimensional stationary wavelet transform was performed on multi-focus data to obtain wavelet coefficients. Differential evolution based on joint weighted evaluation was then employed to optimize the block size of division. Corresponding sub-coefficients of multi-focus data were fused with the proposed fusion rule. Finally, large volumetric and high-resolution photoacoustic imaging can be achieved by applying the inverse stationary wavelet transform. Further details can be found in the article by Xianlin Song, Sihang Li, Zhuangzhuang Wang, and| Xiongjun Cao ( e202200234 )
Beautiful underwater view of an edible brown alga, Sargassum fusiforme (Fucales, Phaeophyceae) at the rocky shore in Sakurajima, Kagoshima, Japan (Photo by Ryuta Terada). Characteristic responses of the PSII photochemical efficiency on desiccation and salinity gradients in S. fusiforme are reported by Yonemori et al. in this issue.
A dual‐raster‐scanned photoacoustic microscope (DRS‐PAM) was reported, which integrates a two‐dimensional motorized translation stage for large field‐of‐view imaging and a two‐axis fast galvanometer scanner for real‐time imaging. The DRS‐PAM provides a flexible transition from wide‐field monitoring the vasculature of organs to real‐time imaging of local dynamics. Further details can be found in the article by Fei Yang, Zhiyang Wang, Wuyu Zhang, et al. ( e202000022 ).
Jackson County, Illinois, U.S.A., Photo by Nathan Soley (right) Champaign County, Illinois, U.S.A., Photo by Nathan Soley (left) Soley and Sipes “Reproductive biology and pollinators of the invasive shrub Autumn olive (Elaeagnus umbellata Thunberg)”. https://doi.org/10.1111/1442-1984.12307
This study presents a novel intraoperative in vivo imaging approach which harnessed Cerenkov luminescence (CL) to detect primary and metastatic colorectal cancer (CRC) using clinically approved radiopharmaceuticals. In the mice and swine experiments, the proposed approach effectively improved the effect of CRC surgery. The approach is believed to be promising for utilizing CL in open surgery. Further details can be found in the article by Zeyu Zhang, Yawei Qu, Yu Cao et al. ( e201960152 )
A Orobanche boninsimae and its visitors, Japanese white-eyes (Zosterops japonicus). Photo by Akihiro Nishimura at Chichijima Island, the Bonin Islands, Japan. Nishimura & Takayama (2023) “First record of potential bird pollination in the holoparasitic genus Orobanche L.” Plant Species Biology, 6–17 https://doi.org/10.1111/1442-1984.12389
We report on an attempt to increase the therapeutic effect of photodynamic therapy using a lipid nanoparticle (LNP). The findings indicate that the internal structure of the LNPs change depending on the amount of photosensitizer in the particle. The photoactivity and cell-killing effect of photosensitizer also changed with increasing amount of cargo, suggesting that the internal structure of the LNP is an important factor that affect the therapeutic effect. Further details can be found in the article by Fumika Kubota, Satrialdi, Yuta Takano, Masatoshi Maeki, Manabu Tokeshi, Hideyoshi Harashima, and Yuma Yamada ( e202200119 ).
The detection of colon cancer by using Poincaré sphere and 2D polarimetric imaging approach. Further details can be found in the article by Deyan Ivanov, Viktor Dremin, Alexander Bykov, Ekaterina Borisova, et al. ( e202000082 ).
A false‐colored and merged image of fresh, ex vivo rat kidney acquired using an excitation‐scanning hyperspectral imaging system. The spectral image was acquired using excitation wavelengths from 360 to 550 nm. Colors represent principal components extracted from a spectral image cube featuring no added labels or markers. Further details can be found in the article by Peter F. Favreau, Joshua A. Deal, Bradley Harris, et al. ( e201900183 ).
Cover Image Tulipa pumila. This photo was taken by Sandro Pratesi at Doccino at the municipality of Riparbella, province of Pisa, Tuscany, Italy (DOI: 10.1111/1442-1984.12267 ).
The cover image is based on the Original Article Regulatory role of human fibrocartilage stem cells in condyle osteochondroma by Qing Yin et al., https://doi.org/10.1111/cpr.13342 .
Confocal Raman microscopy provides composition and constitution of label-free samples at high spatial-resolution. In this study, the histology of atherosclerotic arteries was measured using a custom-built confocal Raman microscopy that was developed to improve imaging speed, diffraction efficiency, and spectral resolution. Additionally, the machine learning method was used to enhance the accuracy of classification. Results show that each layer of arteries and lipid-rich inflamed plaque can be successfully characterized. Further details can be found in the article by Jingchao Xing, Dong-Ryoung Lee, Jin Won Kim, and Hongki Yoo ( e202200243 ).
Cover Image The pistillate-phase flowers of Artabotrys (Annonaceae): A. blumei (left) and A. brachypetalus (right). Photos by Junhao Chen, taken in Hong Kong and South Africa, respectively (DOI: 10.1111/1442-1984.12273 ).
A type of compact and cost‐effective light‐sheet imaging device, termed sub‐voxel‐resolving light‐sheet add‐on module (SLAM), is developed to cooperate with conventional 2D epifluorescence microscope, allowing high‐contrast, resolution‐improved 3D imaging of various biological samples at high throughput. Further details can be found in the article by Fang Zhao, Yicong Yang, Yi Li, et al. ( e201960243 ).
An optical fan was demonstrated to screen leukemia cells from the blood sample at the single‐cell level in a noninvasive and noncontact manner. Further details can be found in the article by Xiaoshuai Liu, Yuchao Li, Xiaohao Xu, Yao Zhang, Baojun Li ( e201900155 ).
