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TOMM70 is a subunit of the outer mitochondrial membrane translocase that plays a major role as a receptor of hydrophobic pre-proteins targeted to the mitochondria. We report the presence of two nuclear respiratory factor 2 (NRF-2) binding motifs in the 5'-flanking region of the human Tomm70 gene and establish their essential role for promoter activity by using reporter assays in HeLa cells. We show that both NRF-2 binding sites are functional and present evidence that interactions between these sites and a CpG island contribute to expression. Mobility shift assays show that these NRF-2 sites are specifically recognized by NRF-2 present in HeLa nuclear extracts. 相似文献
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Control of mitochondrial biogenesis during myogenesis 总被引:5,自引:0,他引:5
Kraft CS LeMoine CM Lyons CN Michaud D Mueller CR Moyes CD 《American journal of physiology. Cell physiology》2006,290(4):C1119-C1127
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