共查询到20条相似文献,搜索用时 78 毫秒
1.
Pilar Gonzalo Marta C. Guadamillas María Victoria Hernández-Riquer Ángela Pollán Araceli Grande-García Rubén A. Bartolomé Amit Vasanji Chiara Ambrogio Roberto Chiarle Joaquín Teixidó Juha Risteli Suneel S. Apte Miguel A. del Pozo Alicia G. Arroyo 《Developmental cell》2010,18(1):77-89
Highlights? Myeloid cells fuse during osteoclast and giant cell formation ? MT1-MMP is required for this fusion in vitro and in vivo ? MT1-MMP regulates the GTPase Rac1 through p130Cas binding ? MT1-MMP proteolytic activity is not required 相似文献
2.
Paulo A. Gameiro Juanjuan Yang Ana M. Metelo Rocio Pérez-Carro Rania Baker Zongwei Wang Alexandra Arreola W. Kimryn Rathmell Aria Olumi Pilar López-Larrubia Gregory Stephanopoulos Othon Iliopoulos 《Cell metabolism》2013,17(3):372-385
Highlights? HIF is necessary and sufficient to induce reductive carboxylation in RCC cell lines ? HIF promotes the reductive carboxylation flux by reducing citrate levels ? HIF-expressing tumors display reductive carboxylation in vivo ? HIF renders RCC cells sensitive to glutaminase inhibition in vitro and in vivo 相似文献
3.
Milka Sarris Jean-Baptiste Masson Damien Maurin Lieke M. Van der Aa Pierre Boudinot Hugues Lortat-Jacob Philippe Herbomel 《Current biology : CB》2012,22(24):2375-2382
Highlights? Chemokines form tissue-bound gradients in vivo through heparan sulfate proteoglycans ? Chemokines guide neutrophils in vivo as haptotactic gradients ? Chemokines guide neutrophils toward infection loci by triggering orthotaxis ? Chemokines locally restrict neutrophil motility at sites of infection 相似文献
4.
Celine Delaloy Lei Liu Jin-A Lee Hua Su Fanxia Shen Guo-Yuan Yang William L. Young Kathy N. Ivey Fen-Biao Gao 《Cell Stem Cell》2010,6(4):323-335
Highlights? miR-9 is expressed in hESC-derived early hNPCs and their progeny ? Loss of miR-9 inhibits early hNPC proliferation and delays maturation ? miR-9 knockdown promotes hNPC migration in vitro and in vivo ? Stathmin is a target of miR-9 and mediates its effects in early hNPCs 相似文献
5.
Kuancan Liu Ming Jiang Yun Lu Hao Chen Jun Sun Shaoping Wu Wei-Yao Ku Hiroshi Nakagawa Yoshiaki Kita Shoji Natsugoe Jeffrey H. Peters Anil k. Rustgi Mark W. Onaitis Amy Kiernan Xiaoxin Chen Jianwen Que 《Cell Stem Cell》2013,12(3):304-315
Highlights? Sox2+ve basal stem/progenitor cells self-renew and differentiate in vitro and in vivo ? Conditional Sox2 overexpression promotes the expansion of basal progenitor cells ? Sox2 cooperates with an inflammatory microenvironment to induce squamous cancer ? Sox2 and Stat3 together transform mouse and human esophageal progenitor cells 相似文献
6.
Bérengère de Laval Patrycja Pawlikowska Laurence Petit-Cocault Chrystèle Bilhou-Nabera Geneviève Aubin-Houzelstein Michèle Souyri Frédéric Pouzoulet Murielle Gaudry Françoise Porteu 《Cell Stem Cell》2013,12(1):37-48
Highlights? Mpl loss increases γ-irradiation-induced genomic instability in HSPCs ? TPO promotes DNA repair in vitro and in vivo in HSPCs ? TPO increases DNA-PK activity and NHEJ-mediated repair efficiency in HSPCs ? A single TPO injection before mouse TBI limits long-term HSC injury and mutagenesis 相似文献
7.
Abdelfattah El Ouaamari Dan Kawamori Ercument Dirice Chong Wee Liew Jennifer L. Shadrach Jiang Hu Hitoshi Katsuta Jennifer Hollister-Lock Wei-Jun Qian Amy J. Wagers Rohit N. Kulkarni 《Cell reports》2013,3(2):401-410
Highlights? Circulating nonneuronal factors drive β cell replication in LIRKO mice ? LIRKO serum increases mouse and human islet β cell replication in vitro ? LIRKO serum induces selective β cell replication in vivo ? Hepatocyte-derived factors stimulate mouse and human β cell replication in vitro 相似文献
8.
Dominique Seetapun Brian T. Castle Alistair J. McIntyre Phong T. Tran David J. Odde 《Current biology : CB》2012,22(18):1681-1687
Highlights? The microtubule (MT) GTP cap is ~750 tubulin subunits in vivo and extends over 1 μm ? EGFP brightness can be calibrated in vivo using GFP-tubulin signals from MTs ? The presence of GTP-tubulin in the MT lattice influences MT shortening and rescue ? MT tip trackers, like EB1, can be highly concentrated at the MT plus end (~100 μM) 相似文献
9.
Ruiyu Xie Logan J. Everett Hee-Woong Lim Nisha A. Patel Jonathan Schug Evert Kroon Olivia G. Kelly Allen Wang Kevin A. D’Amour Allan J. Robins Kyoung-Jae Won Klaus H. Kaestner Maike Sander 《Cell Stem Cell》2013,12(2):224-237
Highlights? Pancreatic lineage progression is governed by PcG-dependent chromatin remodeling ? A temporal chromatin signature predicts regulators of pancreatic development ? Endocrine cells differentiated from hESCs in vivo are similar to native human islets ? In vitro-produced malfunctioning endocrine cells exhibit aberrant chromatin structure 相似文献
10.
Olivier Genest Michael Reidy Timothy O. Street Joel R. Hoskins Jodi L. Camberg David A. Agard Daniel C. Masison Sue Wickner 《Molecular cell》2013,49(3):464-473
Highlights? Using a genetic screen, we selected for defective mutants of E. coli Hsp90 ? The mutants are impaired in ATP-dependent chaperone activity ? The mutations define a client-binding region of E. coli Hsp90 ? Mutation of homologous residues in yeast Hsp90 causes in vivo and in vitro defects 相似文献
11.
Highlights? PARP1 recognizes DNA strand breaks through substrate-assisted dimerization. ? PARP1 ZFIII and WGR domains link DNA break recognition to enzyme activation. ? Tankyrase-dependent PARylation regulates Wnt signalling and Cherubism syndrome. 相似文献
12.
Jia-Hui Ng Vibhor Kumar Masafumi Muratani Petra Kraus Jia-Chi Yeo Lai-Ping Yaw Kun Xue Thomas Lufkin Shyam Prabhakar Huck-Hui Ng 《Developmental cell》2013,24(3):324-333
Highlights? Modified small-scale ChIP-seq method applicable to small number of cells ? Genome-wide maps of H3K4me3, H3K27me3, H3K27ac, and H2BK20ac of germ cells in vivo ? Identification of active and inactive regulatory elements in germ cells in vivo ? Germ cell H3K27me3 regions are enriched for retrotransposon repeats 相似文献
13.
Sa Kan Yoo Qing Deng Peter J. Cavnar Yi I. Wu Klaus M. Hahn Anna Huttenlocher 《Developmental cell》2010,18(2):226-236
Highlights? Neutrophil motility in live zebrafish requires PI(3)K activity at the leading edge ? Localized photo-activation of Rac can to direct migration in vivo ? Rac activation rescues protrusion but not polarization in PI(3)K-inhibited cells ? Separable two-tier regulation of F-actin dynamics and protrusion by PI(3)K 相似文献
14.
Reut Shalgi Jessica A. Hurt Irina Krykbaeva Mikko Taipale Susan Lindquist Christopher B. Burge 《Molecular cell》2013,49(3):439-452
Highlights? Global translation elongation pause at 5′ end of ORFs in severe heat shock ? Modulation of Hsp70 levels/activity affects elongation pausing ? Pausing is associated with hydrophobic N termini ? Hsp70 shows reduced ribosome association and altered interactions in heat stress 相似文献
15.
Venters BJ Wachi S Mavrich TN Andersen BE Jena P Sinnamon AJ Jain P Rolleri NS Jiang C Hemeryck-Walsh C Pugh BF 《Molecular cell》2011,41(4):480-492
Highlights? Genomic maps of 200 yeast regulators in normal and stress conditions provide a compendium for discovery ? SAGA assembly pathway is associated with more regulation than the TFIID pathway ? SAGA-linked regulators are distal, and TFIID-linked regulators are proximal to the promoter ? During heat shock, SAGA- and TFIID-linked regulators displayed distinct mobilization patterns 相似文献
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17.
Wenhua Wang Alexandre Maucuer Ankit Gupta Valérie Manceau Karen R. Thickman William J. Bauer Scott D. Kennedy Joseph E. Wedekind Michael R. Green Clara L. Kielkopf 《Structure (London, England : 1993)》2013,21(2):197-208
Highlights? Splicing factor SF1 phosphorylation on a conserved SPSP motif is required in vivo ? SPSP phosphorylation (P) induces local folding within an SF1/U2AF65 interface ? Phosphorylation promotes an acutely bent (P)SF1/U2AF65/RNA conformation 相似文献
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19.
Mark A. Chua Sonja Schmid Jasmine T. Perez Ryan A. Langlois Benjamin R. tenOever 《Cell reports》2013,3(1):23-29
Highlights? Demonstrates how a bicistronic gene can influence biological circuits ? Characterizes potency of innate immune antagonism in vivo ? Demonstrates how host factors can contribute to the timing of a virus life cycle ? Implicates NEP accumulation in the timing of IAV infection 相似文献
20.
Chunzhang Yang Kristin Huntoon Alexander Ksendzovsky Zhengping Zhuang Russell R. Lonser 《Cell reports》2013,3(1):52-59
Highlights? Loss of mutant pVHL in VHL-associated tumors is due to rapid degradation ? Mutant pVHL maintains its intrinsic function as an E3 ligase ? HDACIs stabilize mutant pVHL and ameliorate tumor growth in vivo ? HDACIs represent a targeted therapy for VHL-associated tumors 相似文献