共查询到20条相似文献,搜索用时 31 毫秒
1.
Joke G. van Bemmel Guillaume J. Filion Arantxa Rosado Wendy Talhout Marcel de Haas Tibor van Welsem Fred van Leeuwen Bas van Steensel 《Molecular cell》2013,49(4):759-771
Highlights? DamID identifies 42 previously unknown chromatin proteins ? Binding maps of new and known chromatin components yield a chromatin network model ? The network model predicts functions of most of the 42 new chromatin proteins ? The chromatin protein network is functionally compartmentalized 相似文献
2.
Ruiyu Xie Logan J. Everett Hee-Woong Lim Nisha A. Patel Jonathan Schug Evert Kroon Olivia G. Kelly Allen Wang Kevin A. D’Amour Allan J. Robins Kyoung-Jae Won Klaus H. Kaestner Maike Sander 《Cell Stem Cell》2013,12(2):224-237
Highlights? Pancreatic lineage progression is governed by PcG-dependent chromatin remodeling ? A temporal chromatin signature predicts regulators of pancreatic development ? Endocrine cells differentiated from hESCs in vivo are similar to native human islets ? In vitro-produced malfunctioning endocrine cells exhibit aberrant chromatin structure 相似文献
3.
4.
Pietro Vella Andrea Scelfo SriGanesh Jammula Fulvio Chiacchiera Kristine Williams Alessandro Cuomo Alessandra Roberto Jesper Christensen Tiziana Bonaldi Kristian Helin Diego Pasini 《Molecular cell》2013,49(4):645-656
Highlights? Ogt forms a complex with Tet1 and Tet2 in the nucleus of embryonic stem cells ? Ogt preferentially associates with promoter regions in proximity of TSS ? Ogt shows >90% of colocalization with Tet1 at methylation-free CpG-rich elements ? Tet1 is required for global Ogt chromatin recruitment regulating its activity 相似文献
5.
6.
Hume Stroud Maxim V.C. Greenberg Suhua Feng Yana V. Bernatavichute Steven E. Jacobsen 《Cell》2013,152(1-2):352-364
Highlights? Genome-wide single-nucleotide resolution methylation maps in 86 silencing mutants ? Complex interplays between different DNA methylation pathways ? Identification of novel regulators of DNA methylation 相似文献
7.
Yang Yu Ying Chen Bongwoo Kim Haibo Wang Chuntao Zhao Xuelian He Lei Liu Wei Liu Lai Man N. Wu Meng Mao Jonah R. Chan Jiang Wu Q. Richard Lu 《Cell》2013,152(1-2):248-261
Highlights? Activation of the Brg1 chromatin-remodeling complex drives OPC differentiation ? Olig2 prepatterns and directs Brg1 targeting to oligodendrocyte-specific enhancers ? Functional and stage-dependent Olig2/Brg1 targeting in oligodendrocyte development ? Olig2/Brg1 targeting coupled with epigenetic marking defines oligodendrocyte identity 相似文献
8.
Jaehoon Kim Jung-Ae Kim Robert K. McGinty Uyen T.T. Nguyen Tom W. Muir C. David Allis Robert G. Roeder 《Molecular cell》2013,49(6):1121-1133
Highlights? H2B ubiquitylation directly stimulates H3K4 methylation by the yeast Set1 complex ? Swd2 is not directly required for the H3K4 methylation activity of the yeast Set1 complex ? The Set1 n-SET domain plays a critical role in H2Bub-dependent H3K4 methylation ? Spp1 is conditionally involved in n-SET- and H2Bub-dependent H3K4 methylation 相似文献
9.
Stanevich V Jiang L Satyshur KA Li Y Jeffrey PD Li Z Menden P Semmelhack MF Xing Y 《Molecular cell》2011,41(3):331-342
Highlights? LCMT-1 makes extensive contacts to PP2A active site for methylation of PP2A tail ? PP2A methylation is stimulated by phosphatase activation, hampered by inactivation ? LCMT-1 would facilitate efficient transition of activated PP2A to holoenzymes ? A high-affinity dnLCMT-1 mutant attenuates the cell cycle without causing cell death 相似文献
10.
ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency
Carlos F. Pereira Francesco M. Piccolo Tomomi Tsubouchi Stephan Sauer Natalie K. Ryan Ludovica Bruno David Landeira Joana Santos Ana Banito Jesus Gil Haruhiko Koseki Matthias Merkenschlager Amanda G. Fisher 《Cell Stem Cell》2010,6(6):547-556
Highlights? Mouse pluripotent cells reprogram human B cells in heterokaryons ? ESCs lacking PRC1 or PRC2 cannot successfully reprogram ? Failure of PRC1/2-deficient ESCs to reprogram is functionally dominant ? PRC1/2 play a critical role in the chromatin reorganization required for reprogramming 相似文献
11.
Yu M Mazor T Huang H Huang HT Kathrein KL Woo AJ Chouinard CR Labadorf A Akie TE Moran TB Xie H Zacharek S Taniuchi I Roeder RG Kim CF Zon LI Fraenkel E Cantor AB 《Molecular cell》2012,45(3):330-343
Highlights? PRC1 interacts with Runx1 and CBFβ ? PRC1 and Runx1/CBFβ colocalize on chromatin and coregulate a subset of genes ? PRC1 and Runx1/CBFβ deficiencies generate partial phenocopies of one another in vivo ? Runx1 directly recruits PRC1-independent of PRC2 相似文献
12.
Guanqun Zheng John Arne Dahl Yamei Niu Peter Fedorcsak Chun-Min Huang Charles J. Li Cathrine B. Vågbø Yue Shi Wen-Ling Wang Shu-Hui Song Zhike Lu Ralph P.G. Bosmans Qing Dai Ya-Juan Hao Xin Yang Wen-Ming Zhao Wei-Min Tong Xiu-Jie Wang Chuan He 《Molecular cell》2013,49(1):18-29
Highlights? ALKBH5 is a mammalian m6A RNA demethylase ? RNA demethylation affects mRNA export and RNA metabolism ? RNA demethylation is important for mouse fertility ? Reversible mammalian messenger RNA methylation affects gene expression 相似文献
13.
Alexander D. Ramos Aaron Diaz Abhinav Nellore Ryan N. Delgado Ki-Youb Park Gabriel Gonzales-Roybal Michael C. Oldham Jun S. Song Daniel A. Lim 《Cell Stem Cell》2013,12(5):616-628
Highlights? RNA-seq, RNA Capture-Seq of SVZ-NSCs reveals unannotated lncRNAs and splice variants ? lncRNA loci have dynamic chromatin signatures, including bivalency in SVZ-NSCs ? Online resource facilitates discovery of lncRNAs involved in adult neurogenesis ? lncRNAs can regulate glial-neuronal lineage specification of SVZ-NSCs 相似文献
14.
Lorene Rozier Yige Guo Shaun Peterson Mai Sato Richard Baer Jean Gautier Yinghui Mao 《Molecular cell》2013,49(6):1097-1107
Highlights? The MRN-CtIP pathway is required for metaphase chromosome alignment in egg extracts ? MRN inhibition interferes with spindle assembly around DNA-coated beads ? MRN inhibition in cells causes a metaphase delay and disrupts the RanGTP gradient ? The MRN complex regulates the stable association of RCC1 to chromatin 相似文献
15.
Francesco M. Piccolo Hakan Bagci Karen E. Brown David Landeira Jorge Soza-Ried Amelie Feytout Dylan Mooijman Petra Hajkova Harry G. Leitch Takashi Tada Skirmantas Kriaucionis Meelad M. Dawlaty Rudolf Jaenisch Matthias Merkenschlager Amanda G. Fisher 《Molecular cell》2013,49(6):1023-1033
Highlights? EGCs can erase DNA methylation at ICRs in somatic cells after fusion ? EGCs selectively induce 5hmC accumulation at ICRs in the somatic genome ? Conversion of 5mC to 5hmC at these imprinted domains requires Tet1 ? Tet2 depletion results in delayed reprogramming by EGCs 相似文献
16.
Yumi Kim Junhyun Lim Miji Yeom Hyunmin Kim Jeongsik Kim Lei Wang Woe Yeon Kim David E. Somers Hong Gil Nam 《Cell reports》2013,3(3):671-677
Highlights? GI forms dynamic subnuclear structures ? GI and ELF4 physically interact at nuclear bodies ? ELF4 regulates subnuclear localization of GI ? ELF4 sequesters GI to nuclear bodies from the CO promoter 相似文献
17.
Isabel Beerman Christoph Bock Brian S. Garrison Zachary D. Smith Hongcang Gu Alexander Meissner Derrick J. Rossi 《Cell Stem Cell》2013,12(4):413-425
Highlights? Locus-specific alterations of the DNA methylome accompany HSC aging ? Methylation changes target genes expressed downstream of HSCs to alter HSC potential ? HSC potential, DNA methylation, and replicative limits depend on divisional history ? Aging and forced proliferation of HSC results in DNA hypermethylation of PRC2 targets 相似文献
18.
Highlights? ESCs with short telomeres do not stably differentiate and can resume proliferation ? Critically short telomeres impair Nanog regulation during ESC differentiation ? Short telomeres elicit genome-wide DNA hypomethylation and altered H3K27me3 levels ? Impaired DNA methylation and differentiation are rescued by Dnmt3b or telomere elongation 相似文献
19.
Yifeng Xu Yizhong Wang Hume Stroud Xiaofeng Gu Bo Sun Eng-Seng Gan Kian-Hong Ng Steven E. Jacobsen Yuehui He Toshiro Ito 《Current biology : CB》2013,23(4):345-350
Highlights? The Arabidopsis matrix protein TEK silences transposons and repeat-containing genes ? Binding of TEK on targets affects chromatin conformation and histone modifications ? TEK protein associates with FVE/MSI5-containing histone deacetylation complex ? TEK directs repressive modification as a key structural component in gene silencing 相似文献
20.
Maria A. Hahn Runxiang Qiu Xiwei Wu Arthur X. Li Heying Zhang Jun Wang Jonathan Jui Seung-Gi Jin Yong Jiang Gerd P. Pfeifer Qiang Lu 《Cell reports》2013,3(2):291-300
Highlights? 5hmC levels increase in neuronal function-related genes during neurogenesis ? 5hmC gain is accompanied by H3K27me3 loss at promoters and gene bodies ? Gain of 5hmC is not associated with substantial DNA demethylation ? Polycomb and Tet protein together promote proper progression of neurogenesis 相似文献