Changes in Socioeconomic Inequality in Indonesian Children’s Cognitive Function from 2000 to 2007: A Decomposition Analysis

Background

Measuring social inequalities in health is common; however, research examining inequalities in child cognitive function is more limited. We investigated household expenditure-related inequality in children’s cognitive function in Indonesia in 2000 and 2007, the contributors to inequality in both time periods, and changes in the contributors to cognitive function inequalities between the periods.

Methods

Data from the 2000 and 2007 round of the Indonesian Family Life Survey (IFLS) were used. Study participants were children aged 7–14 years (n = 6179 and n = 6680 in 2000 and 2007, respectively). The relative concentration index (RCI) was used to measure the magnitude of inequality. Contribution of various contributors to inequality was estimated by decomposing the concentration index in 2000 and 2007. Oaxaca-type decomposition was used to estimate changes in contributors to inequality between 2000 and 2007.

Results

Expenditure inequality decreased by 45% from an RCI = 0.29 (95% CI 0.22 to 0.36) in 2000 to 0.16 (95% CI 0.13 to 0.20) in 2007 but the burden of poorer cognitive function was higher among the disadvantaged in both years. The largest contributors to inequality in child cognitive function were inequalities in per capita expenditure, use of improved sanitation and maternal high school attendance. Changes in maternal high school participation (27%), use of improved sanitation (25%) and per capita expenditures (18%) were largely responsible for the decreasing inequality in children’s cognitive function between 2000 and 2007.

Conclusions

Government policy to increase basic education coverage for women along with economic growth may have influenced gains in children’s cognitive function and reductions in inequalities in Indonesia.     

‘Arctic Crashes:’ Revisiting the Human-Animal Disequilibrium Model in a Time of Rapid Change

The paper introduces a new vision advanced by the recent project, Arctic People and Animal Crashes: Human, Climate and Habitat Agency in the Anthropocene (2014–2015) developed at the Smithsonian Institution. Unlike earlier top-down models of polar animal-climate-people connections that tied changes in Arctic species’ abundance and ranges to alternating warmer and cooler temperatures or high ice/low sea-ice regimes, rapid animal declines (‘crashes’) may be better approached at regional and local scales. This approach is close to Arctic peoples’ traditional vision that animals, like people, live in ‘tribes’ and that they ‘come and go’ according to their relations with the local human societies. As the Arctic changes rapidly and climate/sea-ice/ecotone boundaries shift, we see diverse responses by Arctic people and animals to environmental stressors. I examine recent data on the status of three northern mammal species – caribou/reindeer, Pacific walrus, and polar bear—during two decades of the ongoing Arctic warming. The emerging record may be best approached as a series of local human-animal disequilibria interpreted from different angles by population biologists, indigenous peoples, and anthropologists, rather than a top-down climate-induced ‘crash.’ Such new understanding implies the varying speed of change in the physical, animal, and human domains, which was not factored in the earlier models of climate–animal–people’s interactions.     

Springtime in the Delta: the Socio-Cultural Importance of Muskrats to Gwich’in and Inuvialuit Trappers through Periods of Ecological and Socioeconomic Change

Global socioeconomic and ecological changes strongly impact Indigenous communities by affecting food security, physical health, and overall wellbeing. Throughout the 1900s, residents of the Mackenzie Delta in Canada’s western Arctic relied heavily on the muskrat (Ondatra zibethicus) for food, fur, and culture, but recent changes to ecological and economic conditions have altered the nature of this relationship. We investigated the role of muskrats in the cultural traditions and land-based livelihoods of the Gwich’in and Inuvialuit residents of the Mackenzie Delta through interviews and meetings with over 70 community members. Although the role of muskrats has changed over the last 100 years, muskrat harvesting continues to offer Delta residents a meaningful way to remain engaged in, perpetuate, and strengthen their cultural identity and land-based traditions among generations, and ultimately, to foster individual and community wellbeing.     

Smallholders and the ‘Household Responsibility System’: Adapting to Institutional Change in Chinese Agriculture

During the last quarter century, China’s agricultural sector has undergone a dramatic transformation from collective to private production under the so-called “Household Responsibility System.” This incentive system, designed to increase yields, reallocated communal land to peasant households, creating hundreds of millions of smallholders with relative autonomy over land use decisions and crop selection. Based on recent ethnographic research, this paper discusses the smallholder farming system of a mixed-ethnic community that intensively cultivates small land plots for subsistence and market exchange in China’s populous southwestern province of Sichuan. The paper characterizes the smallholder system in terms of biodiversity of plant and animal species, market distribution of crops, multiple cropping systems, and labor and technology inputs. The paper also describes how smallholders adapt their agricultural practices and decisions to changing market conditions and agricultural policies. Significantly, these adaptive strategies focus on shifting to the production of various cash crops, including melons and mangoes. Implications for the long-term viability of China’s smallholders, particularly in ecologically and economically marginal areas, are also discussed.

The Influence of Second-Hand Cigarette Smoke Exposure during Childhood and Active Cigarette Smoking on Crohn’s Disease Phenotype Defined by the Montreal Classification Scheme in a Western Cape Population,South Africa

Background

Smoking may worsen the disease outcomes in patients with Crohn’s disease (CD), however the effect of exposure to second-hand cigarette smoke during childhood is unclear. In South Africa, no such literature exists. The aim of this study was to investigate whether disease phenotype, at time of diagnosis of CD, was associated with exposure to second-hand cigarette during childhood and active cigarette smoking habits.

Methods

A cross sectional examination of all consecutive CD patients seen during the period September 2011-January 2013 at 2 large inflammatory bowel disease centers in the Western Cape, South Africa was performed. Data were collected via review of patient case notes, interviewer-administered questionnaire and clinical examination by the attending gastroenterologist. Disease phenotype (behavior and location) was evaluated at time of diagnosis, according to the Montreal Classification scheme. In addition, disease behavior was stratified as ‘complicated’ or ‘uncomplicated’, using predefined definitions. Passive cigarette smoke exposure was evaluated during 3 age intervals: 0–5, 6–10, and 11–18 years.

Results

One hundred and ninety four CD patients were identified. Cigarette smoking during the 6 months prior to, or at time of diagnosis was significantly associated with ileo-colonic (L3) disease (RRR = 3.63; 95%CI, 1.32–9.98, p = 0.012) and ileal (L1) disease (RRR = 3.54; 95%CI, 1.06–11.83, p = 0.040) compared with colonic disease. In smokers, childhood passive cigarette smoke exposure during the 0–5 years age interval was significantly associated with ileo-colonic CD location (RRR = 21.3; 95%CI, 1.16–391.55, p = 0.040). No significant association between smoking habits and disease behavior at diagnosis, whether defined by the Montreal scheme, or stratified as ‘complicated’ vs ‘uncomplicated’, was observed.

Conclusion

Smoking habits were associated with ileo-colonic (L3) and ileal (L1) disease at time of diagnosis in a South African cohort.     

Genetic Changes Accompanying the Domestication of Pisum sativum: Is there a Common Genetic Basis to the ‘Domestication Syndrome’ for Legumes?

BACKGROUND AND AIMS: The changes that occur during the domestication of crops such as maize and common bean appear to be controlled by relatively few genes. This study investigates the genetic basis of domestication in pea (Pisum sativum) and compares the genes involved with those determined to be important in common bean domestication. METHODS: Quantitative trait loci and classical genetic analysis are used to investigate and identify the genes modified at three stages of the domestication process. Five recombinant inbred populations involving crosses between different lines representing different stages are examined. KEY RESULTS: A minimum of 15 known genes, in addition to a relatively few major quantitative trait loci, are identified as being critical to the domestication process. These genes control traits such as pod dehiscence, seed dormancy, seed size and other seed quality characters, stem height, root mass, and harvest index. Several of the genes have pleiotropic effects that in species possessing a more rudimentary genetic characterization might have been interpreted as clusters of genes. Very little evidence for gene clustering was found in pea. When compared with common bean, pea has used a different set of genes to produce the same or similar phenotypic changes. CONCLUSIONS: Similar to results for common bean, relatively few genes appear to have been modified during the domestication of pea. However, the genes involved are different, and there does not appear to be a common genetic basis to 'domestication syndrome' in the Fabaceae.     

‘The past is a promise to the future’: stories,persons, and the devil in Greece

Drawing on ethnography from central Greece, this article is about the way people narrate their encounters with the devil. Although it echoes the idea that life as told and life as lived are structured in the same way, it takes the argument a step further by suggesting they are structured through a narrative plot wherein the present and the future of the story-tellers pre-date the past of which their stories tell. It also foregrounds the link between this structure and a particular kind of morality which replicates the narrative logic of the stories, giving rise to an inherently relational personhood – a personhood that, just like the way in which its narration destabilizes the logic of before and after, destabilizes the distinction between self and other. Lastly, contextualizing the current economic crisis in the lives of such persons, the article suggests we need to think of it in relation to the devil and the stories people tell of him.     

Between Scylla and Charybdis: renegotiating resolution of the ‘obstetric dilemma’ in response to ecological change

Hominin evolution saw the emergence of two traits—bipedality and encephalization—that are fundamentally linked because the fetal head must pass through the maternal pelvis at birth, a scenario termed the ‘obstetric dilemma’. While adaptive explanations for bipedality and large brains address adult phenotype, it is brain and pelvic growth that are subject to the obstetric dilemma. Many contemporary populations experience substantial maternal and perinatal morbidity/mortality from obstructed labour, yet there is increasing recognition that the obstetric dilemma is not fixed and is affected by ecological change. Ecological trends may affect growth of the pelvis and offspring brain to different extents, while the two traits also differ by a generation in the timing of their exposure. Two key questions arise: how can the fit between the maternal pelvis and the offspring brain be ‘renegotiated’ as the environment changes, and what nutritional signals regulate this process? I argue that the potential for maternal size to change across generations precludes birthweight being under strong genetic influence. Instead, fetal growth tracks maternal phenotype, which buffers short-term ecological perturbations. Nevertheless, rapid changes in nutritional supply between generations can generate antagonistic influences on maternal and offspring traits, increasing the risk of obstructed labour.     

It’s Time for Some “Site”-Seeing: Novel Tools to Monitor the Ubiquitin Landscape in Arabidopsis thaliana

Ubiquitination, the covalent binding of the small protein modifier ubiquitin to a target protein, is an important and frequently studied posttranslational protein modification. Multiple reports provide useful insights into the plant ubiquitinome, but mostly at the protein level without comprehensive site identification. Here, we implemented ubiquitin combined fractional diagonal chromatography (COFRADIC) for proteome-wide ubiquitination site mapping on Arabidopsis thaliana cell cultures. We identified 3009 sites on 1607 proteins, thereby greatly increasing the number of known ubiquitination sites in this model plant. Finally, The Ubiquitination Site tool (http://bioinformatics.psb.ugent.be/webtools/ubiquitin_viewer/) gives access to the obtained ubiquitination sites, not only to consult the ubiquitination status of a given protein, but also to conduct intricate experiments aiming to study the roles of specific ubiquitination events. Together with the antibodies recognizing the ubiquitin remnant motif, ubiquitin COFRADIC represents a powerful tool to resolve the ubiquitination maps of numerous cellular processes in plants.     

Closing the ‘phenotype gap’ in precision medicine: improving what we measure to understand complex disease mechanisms

The central concept underlying precision medicine is a mechanistic understanding of each disease and its response to therapy sufficient to direct a specific intervention. To execute on this vision requires parsing incompletely defined disease syndromes into discrete mechanistic subsets and developing interventions to precisely address each of these etiologically distinct entities. This will require substantial adjustment of traditional paradigms which have tended to aggregate high-level phenotypes with very different etiologies. In the current environment, where diagnoses are not mechanistic, drug development has become so expensive that it is now impractical to imagine the cost-effective creation of new interventions for many prevalent chronic conditions. The vision of precision medicine also argues for a much more seamless integration of research and development with clinical care, where shared taxonomies will enable every clinical interaction to inform our collective understanding of disease mechanisms and drug responses. Ideally, this would be executed in ways that drive real-time and real-world discovery, innovation, translation, and implementation. Only in oncology, where at least some of the biology is accessible through surgical excision of the diseased tissue or liquid biopsy, has “co-clinical” modeling proven feasible. In most common germline disorders, while genetics often reveal the causal mutations, there still remain substantial barriers to efficient disease modeling. Aggregation of similar disorders under single diagnostic labels has directly contributed to the paucity of etiologic and mechanistic understanding by directly reducing the resolution of any subsequent studies. Existing clinical phenotypes are typically anatomic, physiologic, or histologic, and result in a substantial mismatch in information content between the phenomes in humans or in animal ‘models’ and the variation in the genome. This lack of one-to-one mapping of discrete mechanisms between disease and animal models causes a failure of translation and is one form of ‘phenotype gap.’ In this review, we will focus on the origins of the phenotyping deficit and approaches that may be considered to bridge the gap, creating shared taxonomies between human diseases and relevant models, using cardiovascular examples.

     

The phosphorus mass balance: identifying ‘hotspots’ in the food system as a roadmap to phosphorus security

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Highlights? SFA can aid sustainable P management in response to P scarcity and pollution. ? 18 recent P SFAs are assessed at different scales to identify P ‘hotspots’. ? Context-specific analyses are important to quantify P flows in a given system. ? Regardless of scale, P is lost from all sectors between mine, field and fork. ? Losses in the mining/fertilizer and food processing sectors must not be overlooked. ? P use efficiency and recovery is needed in mining, agriculture, food, household and waste sectors.