共查询到20条相似文献,搜索用时 31 毫秒
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《Nucleosides, nucleotides & nucleic acids》2013,32(4-7):1025-1028
The presence of the lamivudine-associated M184V RT mutation increases tenofovir susceptibility in multiple HIV genotypes. Tenofovir is uniquely active against multinucleoside-resistant HIV expressing the Q151M mutation, but shows reduced susceptibility to the T69S insertion mutations. HIV with common forms of zidovudine and lamivudine resistance are susceptible to tenofovir, corroborating phase II clinical results demonstrating the activity of tenofovir DF in treatment-experienced patients. 相似文献
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Miller MD Margot NA Hertogs K Larder B Miller V 《Nucleosides, nucleotides & nucleic acids》2001,20(4-7):1025-1028
The presence of the lamivudine-associated M184V RT mutation increases tenofovir susceptibility in multiple HIV genotypes. Tenofovir is uniquely active against multinucleoside-resistant HIV expressing the Q151M mutation, but shows reduced susceptibility to the T69S insertion mutations. HIV with common forms of zidovudine and lamivudine resistance are susceptible to tenofovir, corroborating phase II clinical results demonstrating the activity of tenofovir DF in treatment-experienced patients. 相似文献
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Involvement of novel human immunodeficiency virus type 1 reverse transcriptase mutations in the regulation of resistance to nucleoside inhibitors 总被引:4,自引:0,他引:4 下载免费PDF全文
Svicher V Sing T Santoro MM Forbici F Rodríguez-Barrios F Bertoli A Beerenwinkel N Bellocchi MC Gago F d'Arminio Monforte A Antinori A Lengauer T Ceccherini-Silberstein F Perno CF 《Journal of virology》2006,80(14):7186-7198
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Kim J Wang L Li Y Becnel KD Frey KM Garforth SJ Prasad VR Schinazi RF Liotta DC Anderson KS 《Bioorganic & medicinal chemistry letters》2012,22(12):4064-4067
Pre-steady state kinetic analysis was utilized for biochemical evaluation of a series of cyclobutyl adenosine nucleotide analogs with HIV-1 RT(WT). The phosphonyl-diphosphate form of the cyclobutyl nucleotide, 5, was the most efficiently incorporated of the series. Nucleotide 5 was fourfold more efficiently incorporated than the FDA approved TFV-DP by RT(WT). The kinetics of incorporation for 5 using the drug resistant mutant enzyme K65R was also determined. Compound 5 was threefold more efficiently incorporated compared to TFV-DP with RT(K65R). These results demonstrate cyclobutyl adenosine analogs can act as substrates for incorporation by HIV-1 RT and be a potential scaffold for HIV inhibitors. 相似文献
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Indolopyridones inhibit human immunodeficiency virus reverse transcriptase with a novel mechanism of action 下载免费PDF全文
Jochmans D Deval J Kesteleyn B Van Marck H Bettens E De Baere I Dehertogh P Ivens T Van Ginderen M Van Schoubroeck B Ehteshami M Wigerinck P Götte M Hertogs K 《Journal of virology》2006,80(24):12283-12292
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