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The frequencies of the Gd-A, Gd-A- and Gd-B alleles have been estimated in a random sample of 455 female and 405 male high school students from Habana. The estimates of the Negro and Caucasian relative contributions to the present genetic make-up of the Habana population, based on these gene frequencies, are 0.20 and 0.80 respectively. 相似文献
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Summary The polymorphism of glyoxalase I (GLO I) was demonstrated in the three main racial groups (Caucasian, Mulattoes, and Negroes) of the Cuban population. The GLO I gene frequencies were used to estimate the relative contribution of Negro and Caucasian genes to the genetic makeup of these three groups.Banco de Sangre Provincial 相似文献
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G. Vaca B. Ibarra D. García Cruz C. Medina F. Romero J. M. Cantú E. Beutler 《Human genetics》1985,71(1):82-85
Summary Two new G-6-PD variants designated G-6-PD Jalisco and G-6-PD Morelia were identified in two unrelated Mexican families. An additional G-6-PD variant was found in each family: G-6-PD trinacria and G-6-PD A-. In both families compound heterozygotes were identified. G-6-PD Jalisco and G-6-PD Morelia belong to Classes 3 and 4, respectively. G-6-PD Morelia is the first variant from its class with a high Km for NADP and a low Ki for NADPH. 相似文献
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S H Chen K S Lin C L Chen 《Proceedings of the National Science Council, Republic of China. Part B, Life sciences》1985,9(4):251-254
The activity of glucose-6-phosphate dehydrogenase (G-6-PD) in leucocytes was studied for erythrocyte G-6-PD deficiency using 49 hemizygous males, 16 heterozygous females, and 19 normal controls. The mean G-6-PD activity in leucocytes of the affected neonates (9.2 +/- 5.4 units) and the children (11.2 +/- 5.3 units) were significantly lower than those of normal newborns (22.9 +/- 5.1 units, P less than 0.01). Seventy percent of the effected newborns and 58% of the children with G-6-PD deficiency had the leucocyte enzyme activity of less than 13 IU/10(9)WBC. The leucocyte enzyme activity (14.6 +/- 8.6 units) of 16 heterozygous G-6-PD deficient mothers was also lower than that of normal controls (23.1 +/- 7.0 units). The present study thus concludes that, in G-6-PD deficient Chinese, the enzyme defect is demonstrable not only in erythrocytes but also in leucocytes. 相似文献
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D Gourdin H Vergnes C Bouloux J Ruffie M Gherardi 《American journal of physical anthropology》1972,37(2):281-287
Blood samples from several populations of baboons (genus Papio) were examined for G-6-PD variants. Several G-6-PD phenotypes were detected by starch gel electrophoresis. The so-called fast variant phenotypes of G-6-PD in baboons differ from human variant phenotypes in several physicochemical constants. 相似文献
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Summary Sample of 981 and 998 South African Negroes belonging to seven different ethnic groups were screned for G-6-PD and 6-PGD phenotypes, respectively. The results are discussed in terms of the interethnic variability and the possible adaptive values of these genetic polymorphisms. Particular attention is paid to the geographic co-distribution and interrelationship of G-6-PD deficiency and the occurrence of malaria in South Africa. 相似文献
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V. Panich 《Human genetics》1973,17(2):169-171
Summary Partially purified G-6-PD from 4 deficient Thai males presenting with acute hemolytic anemia showed low Km G-6-P consumption, and very high consumption of 2d G-6-P, Gal-6-P, and dTPN. DPN consumption was zero. The enzyme had very biphasic pH optimum curve and very low heat stability. Electrophoretic mobility was 103–106% of normal. These properties are very similar to those of G-6-PD Union. The enzyme of these 4 subjects is thus named G-6-PD Union (Thai).
Supported by U.S. Public Health research grant AM 09805 from the National Institute of Arthritis and Metabolic Diseases and research grant no G3/181/74 from the World Health Organization. 相似文献
Zusammenfassung Teilweise gereinigtes G-6-PD von 4 Thai-Männern, die wegen einer hämolytischen Anämie zur Behandlung kamen, zeigten eine niedrige km G-6-P, dagegen hohe 2d G-6-P, Gal-6-P und dTPN-Utilisation. DPN-Utilisation was O. Das Enzym zeigte eine starke biphasische pH-Optimum-Kurve und sehr geringe Hitzestabilität. Die elektrophoretische Wanderungsgeschwindigkeit war 103–106% des Normalen. Diese Eigenschaften sind sehr ähnlich denen des G-6-PD-Union. Deshalb wird das Enzym dieser drei Personen als G-6-PD-Union (Thai) bezeichnet.
Supported by U.S. Public Health research grant AM 09805 from the National Institute of Arthritis and Metabolic Diseases and research grant no G3/181/74 from the World Health Organization. 相似文献
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G-6-PD Intanon. A new glucose-6-phosphate dehydrogenase variant 总被引:2,自引:0,他引:2
V Panich 《Humangenetik》1974,21(2):203-205
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