共查询到20条相似文献,搜索用时 15 毫秒
1.
Background
The growth of new blood vessels in adult life requires the initiation of endothelial cell migration and proliferation from pre-existing vessels in addition to the recruitment and differentiation of circulating endothelial progenitor cells. Signals emanating from growth factors and the extracellular matrix are important in regulating these processes. 相似文献2.
Denis Perko Janja Pretnar-Oblak Mišo Šabovič Marjan Zaletel Bojana Žvan 《BMC neurology》2011,11(1):146
Background
There is a growing interest in the role of the endothelium in migraine. Recently, our group showed differences in endothelial function between the anterior and posterior cerebral circulation in healthy subjects, reduced vasodilatatory capacity of the posterior cerebral circulation and unimpaired systemic endothelial function in migraine patients without comorbidities. However, the relationship between cerebral and systemic endothelial function and the anterior and posterior cerebral endothelial function in migraine patients is still not clear. 相似文献3.
Background
Many in vitro studies have shown that adenosine (Ado) can induce vascular endothelial growth factor (VEGF) mRNA and protein expression and stimulate endothelial proliferation. In the present study, we seek to determine whether Ado can increase circulating levels of VEGF protein in the intact human. 相似文献4.
5.
Toshihiro Nagai Masato Sato Toshiharu Kutsuna Mami Kokubo Goro Ebihara Naoshi Ohta Joji Mochida 《Arthritis research & therapy》2010,12(5):R178
Introduction
In this study, we investigate the efficacy of repairing an osteochondral defect in rabbit knee joints by administering bevacizumab, a humanized monoclonal anti-vascular endothelial growth factor (VEGF) antibody. 相似文献6.
Sukanya Eksakulkla Daroonwan Suksom Prasong Siriviriyakul Suthiluk Patumraj 《Reproductive biology and endocrinology : RB&E》2009,7(1):93
Background
Several kinds of anti-oxidants have drawn a lot of intension for their benefits on vascular protection. In addition, it has been demonstrated that exercise training could improve endothelial function by up-regulating endothelial nitric oxide synthase (eNOS) protein. Therefore, the present study aims to investigate the effects of genistein, a potent phyto-antioxidant, and exercise training on age-induced endothelial dysfunction in relation to NO bioavailability using in situ NO-sensitive fluorescent dye detection. 相似文献7.
Elisa Tinazzi Marzia Dolcino Antonio Puccetti Antonella Rigo Ruggero Beri Maria Teresa Valenti Roberto Corrocher Claudio Lunardi 《Arthritis research & therapy》2010,12(4):R131-15
Introduction
Circulating endothelial cells are increased in patients affected by systemic sclerosis (SSc) and their number strongly correlates with vascular damage. The effects of iloprost in systemic sclerosis are only partially known. We aimed at studying the gene expression profile of circulating endothelial cells and the effects of iloprost infusion and gene expression in patients with systemic sclerosis. 相似文献8.
Ying Xue Zhe Xing Sølve Hellem Kristina Arvidson Kamal Mustafa 《Biomedical engineering online》2009,8(1):34-9
Background
Improved understanding of the interactions between bone cells and endothelial cells involved in osteogenesis should aid the development of new strategies for bone tissue engineering. The aim of the present study was to determine whether direct communication between bone marrow stromal cells (MSC) and human umbilical vein endothelial cells (EC) could influence the osteogenic potential of MSC in osteogenic factor-free medium. 相似文献9.
Anna S?dergren Kjell Karp Kurt Boman Catharina Eriksson Elisabet Lundstr?m Torgny Smedby Lisbet S?derlund Solbritt Rantap??-Dahlqvist Solveig W?llberg-Jonsson 《Arthritis research & therapy》2010,12(4):R158
Introduction
In this study we aimed to investigate whether there are indications of premature atherosclerosis, as measured by endothelial dependent flow-mediated dilation (ED-FMD) and intima media thickness (IMT), in patients with very early RA, and to analyze its relation to biomarkers of endothelial dysfunction, taking inflammation and traditional cardiovascular disease (CVD) risk factors into account. 相似文献10.
Background
Visfatin, a adipocytokine with insulin-mimetic effect, plays a role in endothelial angiogenesis. Hyperbaric oxygen (HBO) has been used in medical practice. However, the molecular mechanism of beneficial effects of HBO is poorly understood. We sought to investigate the cellular and molecular mechanisms of regulation of visfatin by HBO in human coronary arterial endothelial cells (CAECs). 相似文献11.
Background
Lysophosphatidylcholine (LPC), an atherogenic component of oxidized low-density lipoprotein, has been shown to induce the attenuation of endothelium-dependent vascular relaxation. Although benidipine, a dihydropyridine-calcium channel blocker, is known to have endothelial protective effects, the effects of benidipine on LPC-induced endothelial dysfunction remain unknown. We examined the effects of benidipine on the impairment of endothelium-dependent relaxation induced by LPC. 相似文献12.
Tomoaki Ando Robert R Langley Yuping Wang Paul A Jordan Alireza Minagar J Steven Alexander Merilyn H Jennings 《BMC physiology》2007,7(1):10
Background
MAdCAM-1 plays a central role in T-lymphocyte homing to the gut, but its role in chronic liver inflammation remains unknown. Therefore, this study measured MAdCAM-1 expression, regulation, and function in cultured murine hepatic endothelial cells. 相似文献13.
Background
Endothelial tight and adherens junctions control a variety of physiological processes like adhesion, paracellular transport of solutes or trafficking of activated leukocytes. Formation and maintenance of endothelial junctions largely depend on the microenvironment of the specific vascular bed and on interactions of the endothelium with adjacent cell types. Consequently, primary cultures of endothelial cells often lose their specific junctional pattern and fail to establish tight monolayer in vitro. This is also true for endothelial cells isolated from the vein of human umbilical cords (HUVEC) which are widely used as model for endothelial cell-related studies. 相似文献14.
Luis A Brito Saradha Chandrasekhar Steven R Little Mansoor M Amiji 《Biomedical engineering online》2010,9(1):56
Background
In this study, we have examined local non-viral gene delivery, transfection, and therapeutic efficacy of endothelial nitric oxide synthase (eNOS) encoding plasmid DNA administered using coated stents in a rabbit iliac artery restenosis model. 相似文献15.
Massimo Mariotti Sara Castiglioni Daniela Bernardini Jeanette AM Maier 《Immunity & ageing : I & A》2006,3(1):4
Background
The functional changes associated with endothelial senescence may be involved in human aging and age-related vascular disorders. Since the inflammatory cytokine interleukin (IL-)1 inhibits endothelial growth, we evaluated the expression of IL-1α, IL-1β and their antagonist, the IL-1 receptor antagonist (IL-1ra), in endothelial in vitro senescence and quiescence. We also examined the expression of IL-1α in human senescent and progeric fibroblasts. 相似文献16.
Background
Published work suggests that some types of endothelial cells undergo apoptosis in response to ligation of the receptor Fas (CD95, APO1) but other types are resistant. Because heterogeneity among endothelial cells from different tissues, has been demonstrated, the purpose of this study was to determine, if Fas ligation and/or activation by human Fas ligand induces apoptosis and caspase activities, in cultured human coronary artery endothelial cells, and the differences between TNF-a and FAS induced apoptosis in these cells. 相似文献17.
Sandoo A Carroll D Metsios GS Kitas GD Veldhuijzen van Zanten JJ 《Arthritis research & therapy》2011,13(3):R99
Introduction
Patients with rheumatoid arthritis (RA) are at an increased risk for cardiovascular disease (CVD). One of the earliest manifestations of CVD is endothelial dysfunction (ED). ED can occur in both the microcirculation and the macrocirculation, and these manifestations might be relatively independent of each other. Little is known about the association between endothelial function in the microcirculation and the macrocirculation in RA. The objectives of the present study were to examine the relationship between microvascular and macrovascular endothelial function in patients with RA. 相似文献18.
Pal Soltesz Daniel Bereczki Peter Szodoray Maria T Magyar Henrietta Der Istvan Csipo Agota Hajas Gyorgy Paragh Gyula Szegedi Edit Bodolay 《Arthritis research & therapy》2010,12(3):R78
Introduction
The aim of the present study was to investigate the association between cardiovascular risk factors and endothelial dysfunction in patients with mixed connective tissue disease (MCTD) and to determine which biomarkers are associated with atherosclerotic complications, such as cardiovascular disease. 相似文献19.
Nienhuis HL de Leeuw K Bijzet J van Doormaal JJ van Roon AM Smit AJ Graaff R Kallenberg CG Bijl M 《Arthritis research & therapy》2010,12(5):R181
Introduction
The objectives of this study were to determine small arterial elasticity (SAE) in systemic lupus erythematosus (SLE) and to investigate its relationship with intima media thickness (IMT), accumulation of advanced glycation end products (AGEs), endothelial activation and inflammation. 相似文献20.
Jaime Millán Robert J Cain Natalia Reglero-Real Carolina Bigarella Beatriz Marcos-Ramiro Laura Fernández-Martín Isabel Correas Anne J Ridley 《BMC biology》2010,8(1):11