New Year and New Board Members

##正##Following the winter holidays I look forward to the New Yearof 2012,and would like to take the opportunity to express mysincere thanks to all the authors,reviewers and editors of JIPB.Indeed,the Journal thrives on their support.     

抗高脂血症:新靶点与新药研发

高脂血症是引发各种心脑血管疾病最主要的因素之一,通过调节血脂来降低心脑血管疾病的发生率,具有重大意义。从调控内 源性脂质合成、外源性脂质吸收与胆汁酸重吸收、血浆脂蛋白代谢以及脂质代谢等 4 个方面出发,系统概述抗高脂血症的新靶点与新药 研究进展,旨在为高脂血症的治疗药物开发提供参考。     

New Antifungal Agents and New Formulations Against Dermatophytes

A variety of oral and topical antifungal agents are available for the treatment of superficial fungal infections caused by dermatophytes. This review builds on the antifungal therapy update published in this journal for the first special issue on Dermatophytosis (Gupta and Cooper 2008;166:353–67). Since 2008, there have not been additions to the oral antifungal armamentarium, with terbinafine, itraconazole, and fluconazole still in widespread use, albeit for generally more severe or recalcitrant infections. Griseofulvin is used in the treatment of tinea capitis. Oral ketoconazole has fallen out of favor in many jurisdictions due to risks of hepatotoxicity. Topical antifungals, applied once or twice daily, are the primary treatment for tinea pedis, tinea corporis/tinea cruris, and mild cases of tinea unguium. Newer topical antifungal agents introduced include the azoles, efinaconazole, luliconazole, and sertaconazole, and the oxaborole, tavaborole. Research is focused on developing formulations of existing topical antifungals that utilize novel delivery systems in order to enhance treatment efficacy and compliance.     

New and comments

The paper describes a series of experiments designed to enable students to investigate certain physical properties of bone and to relate these properties to the function of bone in living organisms.

The investigations are intended to extend the study of physics across the normal subject division into biology experiments. The integration of basic physics principles with the teaching of biology via simple experiments leads to a deeper understanding of the interdependence of the sciences and an appreciation that study of selflimiting subject areas is a man-made phenomenon not reflected in nature.     

New and notices

This section is collated by Steve Dudley (BOU Administrator). Requests for the publication of information, and other assistance which is considered to be of interest to our readers, will be considered sympathetically. Publicity will be given to relevant grants and awards that can be applied for and to new societies operating within the field of ornithology, birds and birding. Details of conferences, meetings and other events will be included if sent at least six months in advance of the event, and news of members' activities is particularly welcome. All contributions are restricted to 500 words, and should be sent in RTF on disk or by email to: The Administrator, BOU, Department of Zoology, University of Oxford, South Parks Road, Oxford OX1 3PS, UK. Tel./Fax: +44 (0)1865 281842. Email: steve.dudley@bou.org.uk
Deadlines for contributions: 15 September (January issue); 15 December (April issue); 15 March (July issue); 15 June (October issue).     

Modified Oligonucleotides: New Structures,New Properties,and New Spheres of Application

Russian Journal of Bioorganic Chemistry - Nucleic acids have made a long and arduous journey “from the bench to the bedside.” At present, it can be assumed that drugs based on...     

水洞沟旧石器考古研究的新进展与新认识

水洞沟遗址在中国旧石器考古学研究中倍受关注的同时也倍受争议。争议的核心是其旧石器遗存的技术特点、文化属性、来龙去脉和与西方旧石器文化的关系。争议缘起于对核心遗址——第1地点地层、时代和文化演替了解与认识的局限性与模糊性。本文在近年来对遗址区系统调查和多个地点系统发掘与研究的基础上, 对水洞沟遗址群的旧石器时代文化及相关问题提出一系列新的认识,包括水洞沟是一个由多处地点构成的大型露天遗址群; 先民生存活动不局限在一个时期, 文化遗存至少分属7个时段, 据此可建立4万年来区域人群演化序列; 遗址保留的人类文化遗产丰富多样, 除不同技术体系的石制品, 还有骨器、装饰品、复杂用火遗存, 以及对居址复杂利用、对石料热处理和采食植物性食材的诸多信息, 反映古人群具有很强的生存能力和特定的行为方式; 该地区在旧石器时代晚期不同时段存在不同技术体系的考古学文化组合, 出现过勒瓦娄哇+石叶的技术体系与小石片技术体系的交替, 反映末次冰期期间东北亚人群复杂、能动的适应、迁徙、交流过程; 该地区的勒瓦娄哇+石叶的技术体系与本土传统石器工业不存在渊源关系, 应是从西方—西北方向迁移过来的古人群的遗留, 其出现的时间可能早于原先的认定, 而且在消失后没有对本土文化产生明显的影响; 石叶技术组合固然代表一支来自西方的早期现代人群的迁徙和扩散, 但移居者没有对本土人群实现整体替代, 反而被后者取代; 后者在石器技术上保持固有的传统, 但文化遗存中出现小型精制石器、装饰品、石料热处理等早期现代人的行为表征, 反映出这里的现代人起源与扩散模式不是简单的外来移民替代,相反, 本土人群连续演化是主旋律。因而, "连续进化附带杂 交"理论在该地区有着更坚实的考古学基础。     

新疆蝗总科的新属新种及国内新记录（直翅目）

记述采自新疆网翅蝗科1新属1新种,白条蝗属Albistriacris,gen.nov,托里白条蝗Albistriacris tuoliensis,sp.nov,及中国新记录;红足米纹蝗Notostaurus rubripes Mistshenko。模式标本保存于山西师范大学生物系标本室。     

中国蝴蝶新种, 新亚种及新记录种（Ⅲ）（鳞翅目）

记述中国粉蝶科1新种,4新亚种,1新型,1中国新记录种及6个《中国蝶类志》未记述的已知种,所有模式标本保存在西北农林科技大学昆虫博物馆。