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1.
Background
Cyclins regulate the cell cycle in association with cyclin dependent kinases (CDKs). CDKs are under inhibitory control of cyclin dependent kinase inhibitors (CDKIs). 相似文献2.
Background
The long term adverse effects of Severe Acute Respiratory Syndrome (SARS), a viral disease, are poorly understood. 相似文献3.
Wesley Ingwersen Vairavan Subramanian Rita Schenck Lindita Bushi Amy Costello Laura Draucker Cashion East Connie Hensler Holly Lahd Sven-Olof Ryding 《The International Journal of Life Cycle Assessment》2012,17(2):258-263
Purpose
A workshop on Product Category Rule (PCR) alignment was organized by the American Center for LCA PCR Committee. PCR alignment refers to the process of assuring that PCRs (rules for developing LCA-based claims like EPDs) developed by different parties are consistent within product categories. 相似文献4.
Analysing Betula litwinowii encroachment and reforestation in the Kazbegi region,Greater Caucasus,Georgia 下载免费PDF全文
Aims
The encroachment of tree and shrub species in high mountains is an increasing worldwide phenomenon, which is expected to dramatically alter high‐mountain ecosystems and their functioning. Moreover it indicates in some cases a reforestation process, which will result in important ecological and social benefits, including carbon sequestration and protection against landslides. We therefore examined the spatial extent of forest growth and shrub encroachment mainly of birch (Betula litwinowii) in the sub‐alpine belt of the Central Greater Caucasus between 1987 and 2010 and its relation to topographic site conditions.Location
Kazbegi district, Central Greater Caucasus, Georgia.Methods
We analysed 155 vegetation relevés sampled in 2009, 2011 and 2015, mainly derived from the Caucasus Vegetation Database, to obtain information about topographic site conditions and structure of B. litwinowii stands. B. litwinowii forest growth was assessed by digitizing the forest outlines from aerial and space‐borne imagery (1987, 2005 and 2010). To identify areas of B. litwinowii encroachment as an indicator for different encroachment stages, we modelled the tree and shrub cover using the Random Forest algorithm.Results
We found four types of B. litwinowii stands, characterized by different tree and shrub coverage (initial Bromus variegatus–Betula litwinowii encroachment indicating the first stage of succession, Aconitum nasutum–Betula litwinowii forest, Rubus idaeus–Betula litwinowii forest and Rhododendron caucasicum–Betula litwinowii tree line scrubs). B. litwinowii forest increased 25% compared to 1987 mainly in an uphill direction. Furthermore the modelled tree and shrub cover (R2 = .69) could be related to the four vegetation types.Conclusions
Our results indicate a recent trend towards shrub encroachment and consequently reforestation in the Kazbegi region. 相似文献5.
Anti‐Helicobacter pylori therapy in localized gastric mucosa‐associated lymphoid tissue lymphoma: A prospective,nationwide, multicenter study in Japan 下载免费PDF全文
Katsuya Sugizaki Akira Tari Yasuhiko Kitadai Ichiro Oda Shotaro Nakamura Tadashi Yoshino Toshiro Sugiyama 《Helicobacter》2018,23(2)
Background
Helicobacter pylori eradication therapy was approved in Japan for the first‐line, standard treatment of H. pylori‐positive gastric mucosa‐associated lymphoid tissue (MALT) lymphoma. Although several retrospective studies or small‐scale single‐center studies have been reported, a prospective, large‐scale, nationwide, multicenter study has not been reported from Japan.Materials and Methods
We conducted a prospective, nationwide, multicenter study to evaluate the clinical efficacy of rabeprazole‐based triple H. pylori eradication therapy for patients with localized gastric MALT lymphoma in practice‐based clinical trial. A total of 108 H. pylori‐positive patients with stage I/II1 gastric MALT lymphoma underwent H. pylori eradication therapy. The primary endpoints were complete remission (CR) rate and the rate of transfer to secondary treatment. The secondary endpoints were CR maintenance duration and overall survival (OS).Results
CR of lymphoma was achieved in 84 of 97 patients (86.6%), during the period 2.0‐44.7 months (median, 5.3 months) after starting H. pylori eradication treatment. CR was maintained in 77 of 81 patients (95.1%) for 0.4‐53.2 months (median, 33.1 months). Secondary treatments (radiotherapy, rituximab, or gastrectomy) for gastric MALT lymphoma were needed in 10 of the 97 patients (10.31%). During follow‐up, OS rate was 96.9% (94/97) and the causes of 3 deaths were not related to lymphoma.Conclusions
Rabeprazole‐based H. pylori eradication therapy demonstrated a high CR rate, long CR maintenance, and a good OS for patients with localized gastric MALT lymphoma in this prospective, practice‐based, multicenter study. 相似文献6.
J.K. Lutz J. Crawford A.E. Hoet J.R. Wilkins III J. Lee 《Journal of applied microbiology》2013,115(1):171-178
Aims
To evaluate the performance of four sampling methods [contact plates, electrostatic wipes (wipe), swabs and a novel roller sampler] for recovery of Staphylococcus aureus from a stainless steel surface.Methods and Results
Stainless steel test plates were inoculated with Staph. aureus, dried for 24 h and sampled using each of the four methods. Samples were either incubated directly (roller, contact plate) or processed using elution and membrane filtration (swab, wipe). Performance was assessed by calculating the apparent sampling efficiency (ASE), analytical sensitivity (Sn) and percentage of replications with positive growth. The wipe demonstrated the best performance across all inoculating concentrations (ASE48 h = 18%; Sn48 h = 7 CFU per 100 cm2). The swab performed well when corrected for area actually sampled (ASE48 h = 24%; Sn48 h = 76 CFU per 100 cm2). Of the contact‐based methods, the newly developed roller sampler outperformed the contact plate (roller: ASE48 h = 10%; Sn48 h = 17 CFU per 100 cm2; contact plate: ASE48 h = 0·04%; Sn48 h = 1412 CFU per 100 cm2); both contact samplers performed better at higher inoculating concentrations (6E3 CFU per 100 cm2 for the roller and 6E6 CFU per 100 cm2 for the contact plate). Overall, the electrostatic wipe produced the highest number of replications resulting in positive growth (74%24 h, 91%48 h).Conclusions
This study demonstrates that selection of the sampling method must be carefully considered, given that different methods have varying performance.Significance and Impact of the Study
This is the first study assessing static wipes for sampling and one that uses a more real‐world‐relevant 24‐h drying time. The results help with infection control, and environmental health professionals choose better sampling methodologies. 相似文献7.
Scheerens H Su Z Irving B Townsend MJ Zheng Y Stefanich E Chindalore V Bingham CO Davis JC 《Arthritis research & therapy》2011,13(5):R177
Introduction
The purpose of this study was to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of the humanized anti-CD4 monoclonal antibody MTRX1011A in a randomized, double-blind placebo-controlled Phase 1 study in patients with rheumatoid arthritis (RA). 相似文献8.
Seroprevalence of Helicobacter pylori in Korea: A multicenter,nationwide study conducted in 2015 and 2016 下载免费PDF全文
Jeong Hoon Lee Kee Don Choi Hwoon‐Yong Jung Gwang Ho Baik Jong Kyu Park Sung Soo Kim Byung‐Wook Kim Su Jin Hong Hyun Lim Cheol Min Shin Si Hyung Lee Seong Woo Jeon Ji Hyun Kim Cheol Woong Choi Hye‐Kyung Jung Jie‐Hyun Kim Suck Chei Choi Jin Woong Cho Wan Sik Lee Soo‐Young Na Jae Kyu Sung Kyung Ho Song Jun‐Won Chung Sung‐Cheol Yun Korean College of Helicobacter Upper Gastrointestinal Research 《Helicobacter》2018,23(2)
Background
The Korean College of Helicobacter and Upper Gastrointestinal Research has studied Helicobacter pylori (H. pylori) prevalence since 1998 and found a dynamic change in its prevalence in Korea. The aim of this study was to determine the recent H. pylori prevalence rate and compare it with that of previous studies according to socioeconomic variables.Methods
We planned to enroll 4920 asymptomatic Korean adults from 21 centers according to the population distribution of seven geographic areas (Seoul, Gyeonggi, Gangwon, Chungcheong, Kyungsang, Cholla, and Jeju). We centrally collected serum and tested H. pylori serum IgG using a chemiluminescent enzyme immunoassay.Results
We analyzed 4917 samples (4917/4920 = 99.9%) from January 2015 to December 2016. After excluding equivocal serologic results, the H. pylori seropositivity rate was 51.0% (2414/4734). We verified a decrease in H. pylori seroprevalence compared with previous studies performed in 1998, 2005, and 2011 (P < .0001). The H. pylori seroprevalence rate differed by area: Cholla (59.5%), Chungcheong (59.2%), Kyungsang (55.1%), Jeju (54.4%), Gangwon (49.1%), Seoul (47.4%), and Gyeonggi (44.6%). The rate was higher in those older than 40 years (38.1% in those aged 30‐39 years and 57.7% in those aged 40‐49 years) and was lower in city residents than in noncity residents at all ages.Conclusions
Helicobacter pylori seroprevalence in Korea is decreasing and may vary according to population characteristics. This trend should be considered to inform H. pylori‐related policies. 相似文献9.
Nava-Ocampo AA Ramírez-Mora JC Moyao-García D Garduño-Espinosa J Salmerón J 《BMC anesthesiology》2002,2(1):2-8
Background
Several neuromuscular blocking (NMB) agents are available for clinical use in anesthesia. The present study was performed in order to identify preferences and behaviors of anesthesiologists for using vecuronium, rocuronium or other NMB agents in their clinical practice. 相似文献10.
Background
This paper discusses the problem of automated annotation. It is a continuation of the previous work on the A4-algorithm (Adaptive algorithm of automated annotation) developed by Leontovich and others. 相似文献11.
Background
Inhibitor of Apoptosis (IAP) proteins are key intrinsic regulators of apoptosis induced by a variety of triggers. We isolated the rat Inhibitor of Apoptosis genes 1, 2 and 3 and characterized their tissue distribution and expression. 相似文献12.
Background
It is necessary to analyze microarray experiments together with biological information to make better biological inferences. We investigate the adequacy of current biological databases to address this need. 相似文献13.
T.L. Buhr A.A. Young Z.A. Minter C.M. Wells D.C. McPherson C.L. Hooban C.A. Johnson E.J. Prokop J.R. Crigler 《Journal of applied microbiology》2012,113(5):1037-1051
Aims
To develop test methods and evaluate the survival of Bacillus anthracis ?Sterne and Bacillus thuringiensis Al Hakam spores after exposure to hot, humid air.Methods and Results
Spores (>7 logs) of both strains were dried on six different test materials. Response surface methodology was employed to identify the limits of spore survival at optimal test combinations of temperature (60, 68, 77°C), relative humidity (60, 75, 90%) and time (1, 4, 7 days). No spores survived the harshest test run (77°C, 90% r.h., 7 days), while > 6·5 logs of spores survived the mildest test run (60°C, 60% r.h., 1 day). Spores of both strains inoculated on nylon webbing and polypropylene had greater survival rates at 68°C, 75% r.h., 4 days than spores on other materials. Electron microscopy showed no obvious physical damage to spores using hot, humid air, which contrasted with pH‐adjusted bleach decontamination.Conclusions
Test methods were developed to show that hot, humid air effectively inactivates B. anthracis ?Sterne and B. thuringiensis Al Hakam spores with similar kinetics.Significance and Impact of the Study
Hot, humid air is a potential alternative to conventional chemical decontamination. 相似文献14.
Goang-Won Cho Seung Min Shin Hyun Kee Kim Seon-Ah Ha Sanghee Kim Joo-Hee Yoon Soo Young Hur Tae Eung Kim Jin Woo Kim 《BMC cell biology》2007,8(1):50
Background
The Human cervical cancer oncogene (HCCR-1) has been isolated as a human oncoprotein, and has shown strong tumorigenic features. Its potential role in tumorigenesis may result from a negative regulation of the p53 tumor suppressor gene. 相似文献15.
Gortazar C Torres MJ Acevedo P Aznar J Negro JJ de la Fuente J Vicente J 《BMC microbiology》2011,11(1):27
Background
We describe the diversity of two kinds of mycobacteria isolates, environmental mycobacteria and Mycobacterium bovis collected from wild boar, fallow deer, red deer and cattle in Do?ana National Park (DNP, Spain), analyzing their association with temporal, spatial and environmental factors. 相似文献16.
Background
The use of the mechanomyogram (MMG) which detects muscular vibrations generated by fused individual fiber twitches has been refined. The study addresses a comparison of the MMG and surface electromyogram (SEMG) in monitoring muscle fatigue. 相似文献17.
Background
Chronic venous insufficiency is a serious disease for which there is no clearly successful surgical treatment. Availability of a proven prosthetic vein valve could provide such an option by reducing venous reflux while permitting normal antegrade flow. 相似文献18.
Dawn Doré Jonathon de Hoog Graham Giles Changhai Ding Flavia Cicuttini Graeme Jones 《Arthritis research & therapy》2012,14(1):R13-10
Introduction
Bone marrow lesions (BMLs) play an important role in knee osteoarthritis, but their etiology is not well understood. The aim of this longitudinal study was to describe the association between dietary factors, serum lipids, and BMLs. 相似文献19.
Bekele Afessa MD 《BMC pulmonary medicine》2001,1(1):1-7
Background
A prospective observational study was done to describe nonbacterial pulmonary complications in hospitalized patients with human immunodeficiency virus (HIV) infection. 相似文献20.
Roslyn Varki Ed Pequignot Mark C Leavitt Andres Ferber Walter K Kraft 《BMC clinical pharmacology》2009,9(1):2-8