Social science and a post-genomic future: alternative readings of genomic agency

This paper explores competing discourses that envision different socio-technical landscapes opened up by the completion of the map of the human genome in 2003. It examines the ways in which the map, and it organising principle and very rationale--the gene as the sole or prime agent through which to understand the body and its disordering (as disease)--has been interpreted in quite distinct ways. It suggests how the sequences of a genomic map have post-genomic con-sequences that depend on a social rather than simply biological reading of genomic agency. Various accounts of the map and genetic agency or [sic] described, within science, science policy and social science, especially across science and technology studies (STS). The paper concludes with a comparative summary of these positions and asks whether a deconstructive reading of genomic agency by STS analysts might be the basis for a critical re-constructive engagement with post-genomic policy discourse that avoids the over-determination of agency one often finds in the latter.     

In search of the Holy Grail: Media discourse and the new human genetics

It has widely been recognized that the media play a key role in framing debates about genetic issues. This paper provides an overview of the major areas of debate within the social scientific literature on media, public understanding of science and human genetics. It evaluates current approaches to assessing the role of the media in influencing public policy debates. It argues that an analysis of the strategies of news sources should occupy a central role in furthering understanding about the ways in which various social actors seek to influence public policy agendas. At present, within the field of human genetics, only a handful of researchers have systematically examined the strategies of news sources from the perspective of the sources themselves. While recent research has focused upon identifying the major sources and how they are used in science reporting, there remains much to be done in uncovering the processes of negotiation and contestation among social actors prior to issues gaining media coverage.     

Beyond the genome: Reconstituting the new genetics

The mapping and sequencing of the human genome has been the 'Holy Grail' of the new genetics, and its publication marks a turning point in the development of modern biotechnology. However, the question remains: what has been the impact of this discovery on how biotechnology develops in science, and in society at large? Using concepts developed in the social studies of science and technology, the paper begins by rehearsing the historical development of the Human Genome Project (HGP), and suggests that its translation into genomics has been achieved through a process of 'black-boxing' to ensure stabilization. It continues by exploring the extent to which the move to genomics is part of a paradigm shift in biotechnology resulting from the conceptual and organizational changes that have occurred following the completion of HGP. The discussion then focuses on whether genomics can be seen as part of the development of socially robust knowledge in late modernity. The paper suggests that there is strong evidence that a transformation is indeed taking place. It concludes by sketching a social scientific agenda for investigating the reconstitution of the new genetics in a post-genomic era using a 'situated' analytic approach based on an understanding of techno-scientific change as both emergent and contingent.     

Proteomics: A Paradigm Shift

ABSTRACT

Proteome—the protein complement of a genome—has become the protein renaissance and a key research tool in the post-genomic era. The basic technology involves the routine usage of gel electrophoresis and spectrometry procedures for deciphering the primary protein sequence/structure as well as knowing certain unique post-translational modifications that a particular protein has undergone to perform a specific function in the cell. However, the recent advancements in protein analysis have ushered this science to provide deeper, bigger and more valuable perspectives regarding performance of subtle protein-protein interactions. Applications of this branch of molecular biology are as vast as the subject is and include clinical diagnostics, pharmaceutical and biotechnological industries. The 21st century hails the use of products, procedures and advancements of this science as finer touches required for the grooming of fast-paced technology.     

Reshaped destinies: Confronting our human future the need for and promise of an interdisciplinary colloquium

The genomic revolution is bringing with it simultaneous needs for both scientists and nonscientists to understand and assess, in an unvarnished and nonjudgmental way, the implications of genometry. This is the field of science and technology that is taking the genetic code and what we have learned from its secrets, and reshaping our individual and collective human destinies. Together with the editor-in-chief of Gender Medicine, the authors propose an interdisciplinary group—populated by those in science, law, ethics, social policy, and the interested public—to observe, understand, and disseminate information about what is occurring in the fields of biology and chemistry that is the driving force of the genomic revolution. This article discusses the background to the Redefined Destinies Colloquium (RDC) and summarizes 4 of the topics the RDC is studying.     

Migrant African women: tales of agency and belonging

Abstract

This paper explores issues of belonging and agency among asylum seekers and refugee women of African origin in the UK. It discusses the ways these women engendered resistance in their everyday life to destitution, lack of cultural recognition, and gender inequality through the foundation of their own non-governmental organization, African Women's Empowerment Forum, AWEF, a collective ‘home’ space.

The focus of this account is on migrant women's agency and self-determination for the exercise of choice to be active actors in society. It points to what might be an important phenomenon on how local grassroots movements are challenging the invisibility of asylum seekers’ and refugees’ lives and expanding the notion of politics to embrace a wider notion of community politics with solidarity.

AWEF is the embodiment of a social space that resonates the ‘in-between’ experience of migrant life providing stability to the women members regarding political and community identification.     

Yeast genomic databases and the challenge of the post-genomic era

Since the completion of the yeast genome sequence in 1996, three genomic databases, the Saccharomyces Genome Database, the Yeast Proteome Database, and MIPS (produced by the Munich Information Center for Protein Sequences), have organized published knowledge of yeast genes and proteins onto the framework of the genome. Now, post-genomic technologies are producing large-scale datasets of many types, and these pose new challenges for knowledge integration. This review first examines the structure and content of the three genomic databases, and then draws from them and other resources to examine the ways knowledge from the literature, genome, and post-genomic experiments is stored, integrated, and disseminated. To better understand the impact of post-genomic technologies, 20 collections of post-genomic data were analyzed relative to a set of 243 previously uncharacterized genes. The results indicate that post-genomic technologies are providing rich new information for nearly all yeast genes, but data from these experiments is scattered across many Web sites and the results from these experiments are poorly integrated with other forms of yeast knowledge. Goals for the next generation of databases are set forth which could lead to better access to yeast knowledge for yeast researchers and the entire scientific community. Electronic Publication     

How to Etch on China

Abstract

Neoliberalism in government thought and action has taken a very specific route in England. Building on a policy research grounding, and subjecting governmental and ministerial utterances to careful consideration, this article discusses the ways in which the specifically English situation has evolved. It reports that government has been carefully manipulative in terms of meeting its objectives and of finding ways in which to privilege science, technology, engineering, and math subjects in the curriculum of schools, while at the same time downplaying the place and role of the arts. It describes how school performance measures, the English Baccalaureate and Progress 8, are utilized to achieve the desired ends. The means by which governmental policies find their outworkings in the day-to-day lived experiences of schools are discussed, and the pernicious effects of these policies on the operationalizing of arts curricula generally, and music education in particular, are instantiated and discussed.     

非编码RNA与RNA组学研究现状及发展态势

人类基因组计划的完成(2001年)宣告了后基因组时代的到来,也掀起新一轮的RNA研究热潮．作为后基因组时代的科学前沿,RNA组学近年来成为生命科学领域的研究热点,各种新型ncRNA的发现,让人们对遗传信息表达调控网络有了新的认识．结合RNA领域的最新研究进展,《 中国科学C辑：生命科学》 (Science in China Series C-Life Sciences)2009年第3期的8篇述评,从动植物小分子非编码 RNA、miRNA 与细胞分化发育、miRNA 与肿瘤发生及诊断治疗的靶点、核酶的结构与功能、遗传印记起源、miRNA 基因簇的进化等多个方面进行了综述,展现了ncRNA领域的研究现状和发展前景．     

Revealing hidden interval graph structure in STS-content data.

MOTIVATION: STS-content data for genomic mapping contain numerous errors and anomalies resulting in cross-links among distant regions of the genome. Identification of contigs within the data is an important and difficult problem. RESULTS: This paper introduces a graph algorithm which creates a simplified view of STS-content data. The shape of the resulting structure graph provides a quality check - coherent data produce a straight line, while anomalous data produce branches and loops. In the latter case, it is sometimes possible to disentangle the various paths into subsets of the data covering contiguous regions of the genome, i.e. contigs. These straight subgraphs can then be analyzed in standard ways to construct a physical map. A theoretical basis for the method is presented along with examples of its application to current STS data from human genome centers. AVAILABILITY: Freely available on request.     

The law of the sea and regional fisheries policy

Abstract

The consequences of the inevitable acceptance of extended jurisdiction and its impact on fisheries policy in the South Pacific are considered within the framework of the principles outlined at the Third Session of the United Nations Law of the Sea Conference. It is pointed out that the fisheries resources of the region considered are dominated by highly migratory species, particularly tunas, and that the management of the fisheries on these species and the conservation of the species themselves will require comprehensive regional cooperation. Considering the common interests of the developing countries of the region and their comparative lack of experience in fisheries management and in surveillance and enforcement capabilities, it is argued that a regional fisheries agency is required. A wide range of possible functions for such a body is discussed and a three‐phase approach to the development of the agency is proposed.     

The Gender of the Joke: Intimacy and Marginality in Murri Humour

ABSTRACT

Murri Aboriginal humour performances are expressive events in which bodily experiences of policing and agency are discursively commented on in ways that expose Australia's naturalised rationalisations of indigenous governance. Drawing on the ‘out-of-the-way’ position of an indigenous minority encapsulated in the body of the nation-state and the Murri body's intimate ‘out-of-the-way’ folds and crannies, Murri humour delimits and mocks the marginal location Murri people are imagined to spatially and morally occupy within Australia. This work examines how gendered humour renders the Murri individual and social body legible to and for a Murri audience. Such humour performances engage the local and the global, the modern and the traditional, and the hegemonic and the counter-hegemonic in ways that link intimacy, bodies and embodiments to these macro-processes. Unraveling such binaries produces a nuanced analysis in which embodied social actions and sly social critique are captured as they are experienced and expressed through humour.     

Group self-determination,individual rights,or social inclusion? Competing frames for ethnic counting in Hungary

Abstract

Despite increasing demand from policymakers and academics alike, effective policies on ethnic data collection for social inclusion purposes are still absent in most of Europe. This paper proposes to explain the failure to produce these policies by the coexistence of and tensions among contradictory frames on ethnic counting. An in-depth analysis of Hungarian policies reveals that three mutually inconsistent policy frames connect ethnic counting to ethnic diversity in many different ways. These frames are group self-determination, individual rights, and social inclusion. This paper illustrates the tensions among the three through a discussion of two core but divisive aspects of collecting ethnic statistics: defining ethnic classifications for counting and defining membership in ethnic groups for policy purposes. Tensions among the three result in inconsistent and inefficient policies of ethnic counting.     

Making developmental science accessible,usable, and a catalyst for innovation

ABSTRACT

The rapidly moving frontiers of neuroscience, molecular biology, and epigenetics—combined with extensive research in the behavioral and social sciences—are dramatically expanding our understanding of how children develop, how that process can be disrupted, how to get it back on track when it does get derailed, and how to keep it from going off track in the first place. The challenge for educators, other practitioners, policymakers, and change agents across sectors lies in our collective ability to transform cutting-edge knowledge into design principles and concepts that can inform an actionable game plan. The first step in addressing this challenge is the need to identify the most important factors that affect individual variation in learning and behavior—a task that demands recognition of the inextricable interaction between environmental influences and genetic predispositions. Building on this foundational understanding, progress toward substantially better life outcomes for all children will require attention to three objectives: (1) making complex science understandable and accessible for strategically targeted audiences; (2) making credible knowledge usable for educators, other practitioners, parents, policymakers, and civic leaders; and (3) leveraging continuing advances in science to build an R&D platform that drives innovation across multiple sectors within a dynamic ecosystem. The opportunities to leverage scientific insights to catalyze fresh thinking and test new ideas in practice and in policy are plentiful and growing, while the barriers to progress remain formidable. The time to seize the opportunities and overcome the barriers is now.     

Mapping the new molecular landscape: social dimensions of epigenetics

Epigenetics is the study of changes in gene expression caused by mechanisms other than changes in the DNA itself. The field is rapidly growing and being widely promoted, attracting attention in diverse arenas. These include those of the social sciences, where some researchers have been encouraged by the resonance between imaginaries of development within epigenetics and social theory. Yet, sustained attention from science and technology studies (STS) scholars to epigenetics and the praxis it propels has been lacking. In this article, we reflexively consider some of the ways in which epigenetics is being constructed as an area of biomedical novelty and discuss the content and logics underlying the ambivalent promises being made by scientists working in this area. We then reflect on the scope, limits and future of engagements between epigenetics and the social sciences. Our discussion is situated within wider literatures on biomedicine and society, the politics of “interventionist STS”, and on the problems of “caseness” within empirical social science.     

Health and Masculinities Shaped by Agency within Structures among Young Unemployed Men in a Northern Swedish Context

AimThe aim of our paper was to explore expressions of life choices and life chances (aspects of agency within structures) related to power and experiences of health among early unemployed adolescent young men during the transition period to adulthood. These expressions of agency within structure were interpreted in the light of Cockerham’s Health Lifestyles Theory. Furthermore, social constructions of masculinities were addressed in our analysis.MethodsRepeated interviews with ten young men in a cohort of school leavers were analyzed with qualitative content analysis.ConclusionsQualitative research could contribute to develop the understanding of the agency within structure relationships. Future studies need to pay attention to experiences of health among young people at the margin of the labor market in various milieus – and to analyze these in relation to gender constructions and within the frame-work of agency within structure.     

Fine mapping of the clubroot resistance gene, Crr3, in Brassica rapa

A linkage map of Chinese cabbage (Brassica rapa) was constructed to localize the clubroot resistance (CR) gene, Crr3. Quantitative trait loci analysis using an F₃ population revealed a sharp peak in the logarithm of odds score around the sequence-tagged site (STS) marker, OPC11-2S. Therefore, this region contained Crr3. Nucleotide sequences of OPC11-2S and its proximal markers showed homology to sequences in the top arm of Arabidopsis chromosome 3, suggesting a synteny between the two species. For fine mapping of Crr3, a number of STS markers were developed based on genomic information from Arabidopsis. We obtained polymorphisms in 23 Arabidopsis-derived STS markers, 11 of which were closely linked to Crr3. The precise position of Crr3 was determined using a population of 888 F₂ plants. Eighty plants showing recombination around Crr3 locus were selected and used for the mapping. A fine map of 4.74 cM was obtained, in which two markers (BrSTS-41 and BrSTS-44) and three markers (OPC11-2S, BrSTS-54 and BrSTS-61) were cosegregated. Marker genotypes of the 21 selected F₂ families and CR tests of their progenies strongly suggested that the Crr3 gene is located in a 0.35 cM segment between the two markers, BrSTS-33 and BrSTS-78.     

The opposite of witchcraft: Evans‐Pritchard and the problem of the person

The principal legacy of Evans‐Pritchard's 1937 ethnography Witchcraft, oracles and magic among the Azande has been to associate debates over the rationality of witchcraft with its social categorization as a facet of misfortune and enmity. In combination with Evans‐Pritchard's own scepticism regarding witches, this allowed the rationality debate to isolate witchcraft as a distinctive special case. This logical exceptionalism was at odds with Evans‐Pritchard's own assertion of witchcraft's ordinariness, and is not supported by comparable ethnography from the Ladakh region of the Himalayas or by the unabridged versions of Oracles, both of which point towards an indigenous understanding of witchcraft as one variation on a spectrum of everyday action and craft. Instead, a revised reading of Oracles suggests that even the most basic quotidian representations of personal agency raise larger questions as to anthropology's understanding of how humans ascribe action and personhood, a debate which stands at the heart of its status as a science.     

Women,warfare, and the life of agency: Papua New Guinea and beyond

‘Agency’ entered anthropological discourse as a key word from the 1970s in renewed social‐philosophical theorizations (e.g. ‘structure and agency’) as major deterministic theories (e.g. Marxism, structuralism) became less persuasive. It came to play an increasing role in ethnography. Though agency, too, has been partly replaced in some of its earlier semantic range, it has been more fully retained in some areas of usage than others, especially in analyses of subordination in the face of power. This article considers several different conceptualizations of agency. Ethnographically, it focuses on women's differing forms of action in two episodes of warfare in the Highlands of Papua New Guinea. In contrasting these, the article concurs with critiques of approaches to ‘agency’ that turn it into a (liberatory) abstraction, and proposes a view of agency as lived relation of intervention and involvement in social action, inherently linked to values and constraints. The combination may be, but is not always, liberatory. The article considers the life and (partial) expiry of agency as a term of social science art.