共查询到20条相似文献,搜索用时 15 毫秒
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HAYDEN CT 《California medicine》1956,84(3):157-161
The Billroth I gastric resection, with and without vagotomy, was used in 20 selected cases of peptic ulcer. Vagotomy and pyloroplasty is considered the operation of first choice for duodenal ulcer. The cases for Billroth I resections were selected from cases not suitable for pyloroplasty. Operations for peptic ulcer which preserve the gastrointestinal continuity are considered to be physiologically superior. Vagotomy and pyloroplasty, and Billroth I gastric resection both qualify in this regard. The postoperative digestive symptoms after Billroth I gastric resection in the present series were minimal, which tends to confirm this theoretical superiority. 相似文献
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《Cell cycle (Georgetown, Tex.)》2013,12(10):1326-1331
Histidine triad (HIT) proteins represent a small family of nucleotide-binding and -hydrolyzing proteins, which attracted the attention of cancer biologists because their expression is lost in multiple human malignancies. To some of the family members including Fhit, Hint1 and Hint2, a tumor suppressive activity was assigned. Although highly similar in structure, their mode of action appears to be different as they are not able to compensate each other’s function. Surprisingly, in any reported assay system the enzymatic activity of the histidine triad proteins was not required for their tumor suppressor function. Until recently, little was known about the molecular mechanisms mediating the tumor suppressor activities of histidine triad proteins. The identification of new interaction partners started to shed light on the signaling pathways modulated by the HIT proteins. Here, we summarize these findings with special emphasis on the histidine triad proteins Hint1 and Fhit and their repressive activity on the β-catenin signaling function. 相似文献
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Jean‐Baptiste Lamy Christophe Plomion Antoine Kremer Sylvain Delzon 《Molecular ecology》2012,21(23):5646-5655
A key aim of evolutionary biology – inferring the action of natural selection on wild species – can be achieved by comparing neutral genetic differentiation between populations (FST) with quantitative genetic variation (QST). Each of the three possible outcomes of comparisons of QST and FST (QST > FST, QST = FST, QST < FST) is associated with an inference (diversifying selection, genetic drift, uniform selection, respectively). However, published empirical and theoretical studies have focused on the QST > FST outcome. We believe that this reflects the absence of a straightforward biological interpretation of the QST < FST pattern. We here report recent evidence of this neglected evolutionary pattern, provide guidelines to its interpretation as either a canalization phenomenon or a consequence of uniform selection and discuss the significant importance this issue will have for the area of evolutionary biology. 相似文献
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