Candidate chains, unfaithful spell-out, and outwards-looking phonologically-conditioned allomorphy

The question of whether phonologically-conditioned suppletive allomorphy can ever be outwardly sensitive has been a key point of contention in debates between parallel and serial theories of morpho-phonology. Purely serial theories bar outwardssensitivity altogether, while parallel theories permit it across the board. A few examples have been reported, demonstrating the need for some degree of parallelism, but are sufficiently limited to suggest that some degree of serialism is also required. This paper advances a proposal regarding when allomorphs compete serially and when they compete in parallel. Specifically, it proposes that there is a connection between outwards-sensitivity and feature mismatches in morphological spell-out, and suggests a revision to the theory of Optimal Interleaving (OI: Wolf in Optimal interleaving: serial phonology-morphology interaction in a constraint-based model, 2008) which captures this connection. A proposal is also made regarding how to model outwards-sensitive root allomorphy under OI’s assumptions.     

PBP5 complementation of a PBP3 deficiency in Enterococcus hirae

The low susceptibility of enterococci to beta-lactams is due to the activity of the low-affinity penicillin-binding protein 5 (PBP5). One important feature of PBP5 is its ability to substitute for most, if not all, penicillin-binding proteins when they are inhibited. That substitution activity was analyzed in Enterococcus hirae SL2, a mutant whose pbp5 gene was interrupted by the nisRK genes and whose PBP3 synthesis was submitted to nisin induction. Noninduced SL2 cells were unable to divide except when plasmid-borne pbp5 genes were present, provided that the PBP5 active site was functional. Potential protein-protein interaction sites of the PBP5 N-terminal module were mutagenized by site-directed mutagenesis. The T167-L184 region (designated site D) appeared to be an essential intramolecular site needed for the stability of the protein. Mutations made in the two globular domains present in the N-terminal module indicated that they were needed for the suppletive activity. The P197-N209 segment (site E) in one of these domains seemed to be particularly important, as single and double mutations reduced or almost completely abolished, respectively, the action of PBP5.     

Weak radicals,weak suppletion,and phonological indices in Semitic

Paster (2014) has argued that grammar does not distinguish between weak and strong suppletion. This claim is countered in this paper, in an analysis of allomorphic effects in several Semitic languages. What has been traditionally called “root” is broken down into three levels: the formless index (Harley 2014), the phonological index (Borer 2005, 2009, 2013) and its underlying representation. The distinction between the first two leads to a principled structural difference between weak and strong suppletion. Several test cases are presented that require a distinction between the latter two. Two general conclusions are drawn: (1) allomorphy at the different levels has different functions, and (2) in the Semitic root-and-pattern system, weakly suppletive allomorphy never targets the root as a whole; there is no root allomorphy in Semitic.     

Delayed or accelerated oxygen uptake kinetics in the transition from prior exercise?

Reported experimental findings are at variance with each other on the question as to whether O2 uptake (VO2) kinetics are delayed, advanced, or remain unaltered in the transition from prior exercise. Critical examination of these studies tend to suggest that not a great deal of reliance can be placed on their evidence in attempting to resolve the question. They seem to display a disregard for the theoretical properties of the VO2 kinetic model used; in some cases incorrect statistical inferences appear to have been made; most are mathematically incomplete; and the experimental designs have not been appropriately chosen so as to examine the whole question of altered VO2 kinetics. These points are detailed and discussed so that future designed experiments obtain sufficient reliable evidence with which to resolve the question.     

Quantum Models for Psychological Measurements: An Unsolved Problem

There has been a strong recent interest in applying quantum theory (QT) outside physics, including in cognitive science. We analyze the applicability of QT to two basic properties in opinion polling. The first property (response replicability) is that, for a large class of questions, a response to a given question is expected to be repeated if the question is posed again, irrespective of whether another question is asked and answered in between. The second property (question order effect) is that the response probabilities frequently depend on the order in which the questions are asked. Whenever these two properties occur together, it poses a problem for QT. The conventional QT with Hermitian operators can handle response replicability, but only in the way incompatible with the question order effect. In the generalization of QT known as theory of positive-operator-valued measures (POVMs), in order to account for response replicability, the POVMs involved must be conventional operators. Although these problems are not unique to QT and also challenge conventional cognitive theories, they stand out as important unresolved problems for the application of QT to cognition. Either some new principles are needed to determine the bounds of applicability of QT to cognition, or quantum formalisms more general than POVMs are needed.     

ARE MORAL PHILOSOPHERS MORAL EXPERTS?

In this paper I examine the question of whether ethicists are moral experts. I call people moral experts if their moral judgments are correct with high probability and for the right reasons. I defend three theses, while developing a version of the coherence theory of moral justification based on the differences between moral and nonmoral experience: The answer to the question of whether there are moral experts depends on the answer to the question of how to justify moral judgments. Deductivism and the coherence theory both provide some support for the opinion that moral experts exist in some way. I maintain – within the framework of a certain kind of coherence theory – that moral philosophers are ‘semi‐experts’.     

Complexity,adaptive complexity and the Creative View of natural selection

In this paper, I respond to arguments proposed by Brunnander in this journal issue concerning my position regarding the Creative View of natural selection (Razeto-Barry & Frick, 2011). Brunnander argues that (i) the Creative View we defend does not serve to answer William Paley’s question because (ii) Paley’s question is “why there are complex things rather than simple ones” and (iii) natural selection cannot answer this question. Brunnander’s arguments for (iii) defend a Non-creative View of natural selection (sensu Razeto-Barry & Frick, 2011). Here I claim that Brunnander’s arguments for (iii) are mistaken and I also argue that even accepting (iii) we do not have to accept (i), given that statement (ii) is historically and conceptually flawed. Thus here I analyze Paley’s question from a historical point of view and from a contemporary perspective in a quest for the potential conceptual relevance of Paley’s question today. In this vein I argue that from a contemporary point of view statement (iii) may be correct but for different reasons than those adduced by Brunnander.     

The linkage of actin to non-erythroid membranes

The question of how actin filaments are attached to membranes is of central importance to an understanding of how actin gives rise to shape and movement in cells. A number of approaches to this question have been taken, but there have been few definitive answers. Some of the limitations of these approaches are discussed, as well as possible avenues for overcoming them.     

Philosophical problems, cluster concepts, and the many lives of Molyneux’s question

Molyneux’s question, whether the newly sighted might immediately recognize tactilely familiar shapes by sight alone, has produced an array of answers over three centuries of debate and discussion. I propose the first pluralist response: many different answers, both yes and no, are individually sufficient as an answer to the question as a whole. I argue that this is possible if we take the question to be cluster concept of sub-problems. This response opposes traditional answers that isolate specific perceptual features as uniquely applicable to Molyneux’s question and grant viability to only one reply. Answering Molyneux’s question as a cluster concept may also serve as a methodology for resolving other philosophical problems.     

The need for systematic reviews of reasons

There are many ethical decisions in the practice of health research and care, and in the creation of policy and guidelines. We argue that those charged with making such decisions need a new genre of review. The new genre is an application of the systematic review, which was developed over decades to inform medical decision-makers about what the totality of studies that investigate links between smoking and cancer, for example, implies about whether smoking causes cancer. We argue that there is a need for similarly inclusive and rigorous reviews of reason-based bioethics, which uses reasoning to address ethical questions. After presenting a brief history of the systematic review, we reject the only existing model for writing a systematic review of reason-based bioethics, which holds that such a review should address an ethical question. We argue that such a systematic review may mislead decision-makers when a literature is incomplete, or when there are mutually incompatible but individually reasonable answers to the ethical question. Furthermore, such a review can be written without identifying all the reasons given when the ethical questions are discussed, their alleged implications for the ethical question, and the attitudes taken to the reasons. The reviews we propose address instead the empirical question of which reasons have been given when addressing a specified ethical question, and present such detailed information on the reasons. We argue that this information is likely to improve decision-making, both directly and indirectly, and also the academic literature. We explain the limitations of our alternative model for systematic reviews.     

Prospects for Using the Theory of Activity in Ethnopsychology

The question of the causes of differences in mental activity among different peoples has a long history. Each of the different branches of psychology deals with this question in its own way, but the basic factors that they identify are the same. Those analyzed in ethnopsychology, for instance, may be divided into several basic groups.     

Microbe-plant competition, allelopathy and arctic plants

Michelsen et al. (1995) present results of an experiment in which aqueous leaf extracts of three arctic woody plant species were found to inhibit growth and nutrient acquisition of three graminoid species, and suggested that microbial nutrient immobilisation, rather than allelopathy, was responsible for the observed trends. In doing this they also question previous work proposing that the Arctic dwarf shrub Empetrum hermaphroditum is allelopathic. We suggest that their conclusions are not unequivocally supported by their data. Firstly we indicate that the approaches used for estimating microbial nutrient immobilisation are questionable. Secondly we indicate that most of the trends that they discussed are based on data in which the treatments and controls are not significantly different for the majority of cases. Finally we respond specifically to their criticisms of previous work on E. hermaphroditum. While the question of how arctic plants interact is an interesting one, we conclude that this question cannot be answered by their data. Received: 20 November 1995 /Accepted: 10 July 1996     

Evolutionary dynamics of cycle length in pearl millet: the role of farmer��s practices and gene flow

In the Sahel of Africa, farmers often modify their cultivation practices to adapt to environmental changes. How these changes shape the agro-biodiversity is a question of primary interest for the conservation of plant genetic resources. We addressed this question in a case study on pearl millet in south western Niger where farmers used to cultivate landraces with different cycle length in order to cope with rain uncertainty. Early and late landraces were previously grown on distant fields. Nowadays, mostly because of human population pressure and soil impoverishment, it happens that the two types of landraces are grown on adjacent fields, opening the question whether gene flow between them may occur. This question was tackled through a comparative study among contrasting situations pertaining to the spatial distribution of early and late landraces. Observations of flowering periods showed that pollen flow between the two landraces is possible and has a preferential direction from early to late populations.     

Navigating the pathway from embryonic stem cells to beta cells

The compelling goal of using in vitro differentiation of stem cells to obtain replacement pancreatic beta cells that are clinically effective in treating diabetes has until now eluded researchers. This difficulty raises the question of whether more effective strategies are available. We propose that the native embryonic pathway leading to the definitive endoderm lineage, and continuing on to the endocrine pancreas, is the one most likely to succeed for the in vitro differentiation of embryonic stem cells. We question however whether gain-of-function approaches involving genes necessary for beta cell development are destined to work effectively, and suggest alternative approaches to identifying conditions sufficient for in vitro beta cell differentiation.     

Are Phase 1 Trials Therapeutic? Risk,Ethics, and Division of Labor

Despite their crucial role in the translation of pre‐clinical research into new clinical applications, phase 1 trials involving patients continue to prompt ethical debate. At the heart of the controversy is the question of whether risks of administering experimental drugs are therapeutically justified. We suggest that prior attempts to address this question have been muddled, in part because it cannot be answered adequately without first attending to the way labor is divided in managing risk in clinical trials. In what follows, we approach the question of therapeutic justification for phase 1 trials from the viewpoint of five different stakeholders: the drug regulatory authority, the IRB, the clinical investigator, the referring physician, and the patient. Our analysis shows that the question of therapeutic justification actually raises multiple questions corresponding to the roles and responsibilities of the different stakeholders involved. By attending to these contextual differences, we provide more coherent guidance for the ethical negotiation of risk in phase 1 trials involving patients. We close by discussing the implications of our argument for various perennial controversies in phase 1 trial practice.     

Spongiform encephalopathies and prions: An overview of pathology and disease mechanisms

Abstract The etiology of spongiform encephalopathies has been sharply contested for decades. At the heart of the issue is the question of disease origin: Are prion diseases representative of primary neurodegenerative genetic disorders, or are they bona fide infectious diseases? This article provides a brief outline of the progress made in the elucidation of prion disease mechanisms in the context of pathological support of the 'protein only' hypothesis. The answer to the above question appears to be that spongiform encephalopathies are uniquely both infectious and genetic neurodegenerative diseases.     

Special hormone-determined constitutional types in women from the anthropological viewpoint

The question is examined, whether in females hormonal determined constitution types are present which would require a different dosage of the estrogen respectively gestagen portion in the compound of ovulation inhibitors. Various aspects of constitution biology as well as of hormone physiology connected with this question are discussed in detail. Provided that a coherence between the hormonal balance and the constitutional type would be present, ovulation inhibitors could be dosed for the estrogen respectively gestagen portion. However, until now such a coherence could not be proved convincingly.     

Specific versus placebo effects in biofeedback: Some brief back-to-basics considerations

Following the semantic complexities raised in earlier papers, this paper seeks to return to some of the more basic considerations arising from the preceding discussion. A critical part of the context of that discussion is the increasingly important issue of accountability. In this context, the citing of supportive studies is not enough, one must also be able to justify the logical relevance of those studies. The discussion therefore turns of the logic of treatment evaluation, which must be treated as objectively as possible. Also critical is the distinction between the question of whether an effect is present and the question of what the source of that question might be. In the quest for treatment evaluation, only the former question is important. However, this quest is one that is in the interest of researchers, clinicians, and consumers, for all of whom only the facts will do.The preparation of this paper was supported by grants from the National Science and Engineering Research Council of Canada to both authors. We are indebted to Hal Scher for comments on an earlier draft.     

Experimente mit Hefe (2)

The so‐called iodine test is ideal for demonstrating the role of the enzyme “amylase” in simple experiments based on a colour reaction when a yeast dough rises, when carbohydrates are digested or when dishes are washed in the dishwasher. The experiments presented can be used to clarify the question of which everyday substances are capable of degrading starch or whether a food contains starch or not. The central question of the experiments is, how yeast makes the bread dough rise despite of its “starch intolerance”.