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1.
Vedat Cinar Rasim Mogulkoc Abdulkerim Kasim Baltaci 《Biological trace element research》2010,134(2):130-135
In the present study, experiments were designed to investigate if supplementation with calcium during 4 weeks had an effect
on blood parameters in sedentary male athletes at rest and exhaustion. Thirty healthy subjects of ages ranging from 18 to
22 years were included in the study. The subjects were separated into three groups, as follows: Group 1 consisted sedentary
athletes receiving 35 mg/kg/day calcium gluconate. Group 2 included subjects equally supplemented with calcium training 90 min/day
for 5 days/week. Group 3 were subject to the same exercise regime but did not receive calcium supplements. Blood parameters
were determined in the experimental subjects at rest and after exhaustion. The leukocyte count (WBC) of athletes in groups
2 and 3 were significantly higher at exhaustion (p < 0.05). There were no significant differences in the WBC of the two supplemented groups. The erythrocyte count (RBC) was
increased in the supplemented athletes after training (p < 0.05), but hemoglobin, hematocrit, and trombocyte levels remained unchanged. The mean corpuscular volume increased in the
calcium-supplemented group at rest (p < 0.05). These results suggest that calcium supplementation only causes increases in white and red blood cell counts in athletes
after exhaustion while other hematological parameters remain unchanged. 相似文献
2.
The effects of a 1-month exercise program and magnesium supplementation on the adrenocorticotropic hormone and cortisol levels
were studied in young tae-kwon-do and sedentary subjects both at rest and exhaustion. The hormone levels were compared before
and after supplementation with 10 mg of magnesium (as magnesium sulfate) per kilogram of body weight. Both exercise and magnesium
supplements caused significant increases of the adrenocorticotropic hormone (p < 0.05). The cortisol levels were increased in training subjects receiving supplements (p < 0.05) but not so in subjects that either trained or received magnesium supplements in an independent manner. The cortisol
levels measured in resting individuals were higher in the supplemented and non-supplemented athletes than those in sedentary
subjects (p < 0.05). The results of this study show that exercise and/or magnesium supplementation causes a rise of the adrenocorticotropic
hormone, whereas cortisol is increased only as a result of combined exhaustion and magnesium supplements. 相似文献
3.
Vedat Cinar Yahya Polat Abdulkerim Kasim Baltaci Rasim Mogulkoc 《Biological trace element research》2011,140(1):18-23
This study was performed to assess how 4 weeks of magnesium supplementation and exercise affect the free and total plasma
testosterone levels of sportsmen practicing tae kwon do and sedentary controls at rest and after exhaustion. The testosterone
levels were determined at four different periods: resting before supplementation, exhaustion before supplementation, resting
after supplementation, and exhaustion after supplementation in three study groups, which are as follows: Group 1—sedentary
controls supplemented with 10 mg magnesium per kilogram body weight. Group 2—tae kwon do athletes practicing 90–120 min/day
supplemented with 10 mg magnesium per kilogram body weight. Group 3—tae kwon do athletes practicing 90–120 min/day receiving
no magnesium supplements. The free plasma testosterone levels increased at exhaustion before and after supplementation compared
to resting levels. Exercise also increased testosterone levels relative to sedentary subjects. Similar increases were observed
for total testosterone. Our results show that supplementation with magnesium increases free and total testosterone values
in sedentary and in athletes. The increases are higher in those who exercise than in sedentary individuals. 相似文献
4.
The hematological effects of oral supplementation of zinc to training athletes are reported in the present study. A total
of 30 subjects between 16 and 22 yr of age volunteered to participate in a 4-wk study. They were equally divided into three
groups. Group 1 acted as resting controls receiving daily doses of 3 mg Zn/kg body wt. Group 2 was actively engaged in wrestling
and exercised for 90–120 min, 5 d a week. Group 3 was also actively engaged in wrestling and exercised for 90–120 min, 5 d
a week, but they were supplemented with 3 mg Zn/kg body wt per day. The erythrocyte, leukocyte, and thrombocyte counts and
the hemoglobin values of all subjects participating in the study were measured before and after exercise at the beginning
and at the end of the 4-wk study period.
In all groups, there were no significant differences in the measured parameters before and after exercise. At the end of the
supplementation period, the parameters of the subjects in groups 1 and 3 were significantly higher than those of group 2,
both before (p<0.005) and after (p<0.05) exercise. These results suggest that zinc supplementation has a positive effect on hematological parameters in athletes. 相似文献
5.
Vedat Cinar Rasim Mogulkoc Abdulkerim Kasim Baltaci Ozgur Bostanci 《Biological trace element research》2010,133(1):29-33
This study was performed to determine how the calcium supplementation for a 4-week period affects the glucose and insulin
levels at rest and at exhaustion in athletes. This is a 4-week study performed on 30 healthy subjects varying between 18 and
22 ages. Subjects were separated into three groups: first group (group supplemented with calcium, sedentary group), second
group (calcium supplementations + exercise group), and third group (training group). Glucose and insulin parameters of the
groups were measured four times, at rest and exhaustion in the beginning of the research and at rest and exhaustion after
the end of 4 weeks application period. Exhaustion measurements both before and after the supplementations significantly decreased
in compared to rest measurements in terms of insulin (p < 0.05). Significant difference was not determined in the glucose values of groups. In terms of glucose, values increased
in all of the three groups occurred with exercise both before and after the supplementation by exercise and exhaustion (p < 0.05). The results of our study indicate that calcium gluconate supplementations for 4 weeks in sedentary subjects and
athletes did not significantly affect plasma insulin levels at rest and exhaustion. However, glucose levels were affected
by calcium supplementation and exhausting exercise in athletes. 相似文献
6.
Denis M. Medeiros Ann Milton Emery Brunett Lucy Stacy 《Biological trace element research》1991,30(1):19-35
Two 6-wk double-blind studies evaluated the effects of supplements of 2 or 3 mg Cu/d on serum copper, ceruloplasmin, red-blood-cell super oxide dismutase (RBC-SOD), total serum cholesterol, and serum lipoprotein-cholesterol fractions in adult males. Study I had 6 supplemented and 8 placebo subjects, whereas study II had 7 and 6, respectively. Copper supplementation did not appear to affect serum copper levels, RBC-SOD, hematocrit, and ceruloplasmin levels when assayed by radial immunoassay diffusion. Supplementation with 2 mg Cu/d produced an increase in LDL cholesterol and the percentage of cholesterol as LDL at wk 4 compared to the placebo group, and a concomitant decline in VLDL-cholesterol levels and the percentage of cholesterol as VLDL. At wk 6, the percentage of cholesterol as LDL increased and that of cholesterol as VLDL decreased compared to baseline values in the supplemented group. Supplements of 3 mg Cu/d increased hemoglobin levels, ceruloplasmin activity, and serum total-cholesterol levels at wk 6 compared to placebos. Differences in cholesterol may be partly explained by variability in the placebo groups in both studies. Copper supplementation effects on cholesterol deserves further investigation. 相似文献
7.
This study was designed to measure the effect of iron supplementation on antioxidant status in iron-deficient anemia, including
the time for hemoglobin normalization and at the time of filling of iron body stores. The extent of plasma lipid peroxidation
was evaluated by measuring the levels of malondialdehyde and glutathione peroxidase (GSH-Px), and the activities of superoxide
dismutase (SOD) and catalase in 63 patients with iron-deficiency anemia before and after 6 wk of iron supplementation and
at the time when body iron stores are saturated. After 6 wk of iron supplementation, a significant decrease of oxidative stress
was observed in the treated subjects relative to controls (p<0.05). No significant differences existed between treated patients at 6 wk and at the end of the study. The erythrocyte levels
of catalase, SOD, and GSH-Px were significantly lower in treated patients relative to controls (p<0.05). These levels increased after 6 wk of supplementation (p<0.05) and showed no significant differences with those at the end of the study. 相似文献
8.
The effects of magnesium supplementation on plasma magnesium, zinc, and copper levels were determined in young adult tae-kwon-do
athletes and sedentary controls at rest and exhaustion. After a 4-week supplementation period with 10 mg/day/kg Mg, the plasma
magnesium, copper, and zinc levels significantly increased in sedentary and training (90–120 min training 5 days a week) subjects
when compared to nonsupplemented controls (p < 0.05). 相似文献
9.
Bonham M O'Connor JM McAnena LB Walsh PM Downes CS Hannigan BM Strain JJ 《Biological trace element research》2003,93(1-3):75-86
Pharmacological doses of zinc can adversely affect body copper status. The resulting copper deficiency can impact directly
upon cholesterol metabolism and a suboptimal copper status has been observed to influence markers of hemostasis (specifically
fibrinogen and the copper-containing coagulation factors V and VIII). The aim of this investigation was to examine the effect
of a low level of zinc supplementation, to include dietary intake, at the United States tolerable upper intake level of 40
mg/d upon indicators of lipid metabolism, hemostasis, and copper. Thirty-eight subjects were recruited onto a double-blind
placebo-controlled intervention trial and randomly selected to one of two groups. Group 1 took zinc supplements (30 mg/d)
for 14 wk followed by copper supplements (3 mg/d) for 8 wk (to counteract adverse effects, if any, of zinc supplementation).
A second group took placebo supplements for the full duration of the trial. Estimated dietary zinc intake approximated 10
mg/d. The effect of supplement was analyzed by repeated-measures analysis of variance (anova). Results indicate that no effect
of zinc supplementation on putative indices of copper status, lipoprotein metabolism, and markers of hemostasis. These results
indicate that short-term low-level zinc supplementation (total intake 40 mg/d) is not detrimental to health. 相似文献
10.
Cinar V 《Neuro endocrinology letters》2007,28(5):708-712
The effect of magnesium on thyroid hormones of sedentars and sportsperson in Tae-Kwon-Do, has been investigated in a 4-weeks training program. Group 1 consisted of sedentars receiving 10 mg/kg/day Mg for 4 weeks. Group 2 consisted of subjects receiving magnesium (Mg) supplement and practicing Tae-Kwon-Do for 90-120 min/day, for five days a week. Group 3 consisted of subjects practicing Tae-Kwon-Do but receiving Mg supplements. TSH levels increased with training and Mg supplementation (p<0.05). Mg increased FT3 values. (p<0.05). TT3 values of groups reduced in all groups (p<005). After supplementation, group 1 had higher TT4 values than groups 1 and 3 and the group 2 had higher TT4 values than the third group (p<005). Results of this research show that training until exhaustion causes reduction in thyroid hormone activity in sedentars and sportsperson. It has been established that Mg supplementation however, prevents reduction in thyroid hormone activity in sedentars and sportsperson. 相似文献
11.
Kara E Ozal M Gunay M Kilic M Baltaci AK Mogulkoc R 《Biological trace element research》2011,143(3):1435-1440
The present study aims to examine the effect of zinc supplementation on the release of some cytokines in young wrestlers actively
involved in wrestling. A total of 40 male subjects of the same age group were included in the study: half were wrestlers and
the other half were not involved in sports. The subjects were equally divided into four groups and treated during an 8-week
period as follows: group 1, zinc-supplemented athletes; group 2, non-supplemented athletes; group 3, zinc-supplemented sedentary
subjects, and group 4, non-supplemented sedentary group. Blood samples were taken from each subject at the beginning and at
the end of the study period. The serum tumor necrosis factor-α (TNF-α), interleukin-2 (IL-2), and interpheron-γ levels (IFN-γ)
were determined using the enzyme-linked immunosorbent assay method. At the beginning of the study, there were no significant
differences of the measured parameters between the four study groups. At the end of the study, the levels of TNF-α, IL-2,
and IFN-γ were significantly higher in the two zinc-supplemented groups compared to those that did not receive supplementation,
regardless of the activity status (p < 0.01). 相似文献
12.
Deficiency in the intake of trace elements, such as copper (Cu), iron (Fe), selenium (Se), and zinc (Zn), is very common in
the general population of most developing countries. A preliminary study in India and Pakistan showing the plasma levels of
Zn and Fe indicates that approx 50% of the subjects who participated have low levels of both Fe and Zn, suggesting a marginal
deficiency. The low plasma levels of these elements are more pronounced in females. The mean levels of Ze, Cu, and Fe in the
plasma of 83 subjects were 0.71 ± 0.11, 0.96 ± 0.10, and 0.80 ± 0.12 mg/L, respectively. The Cu:Zn ratio in the plasma was
1.43 ± 0.16. Three groups of 15 subjects each were given three different levels of oral supplements of Zn (15, 30, and 45
mg of Zn as Zn gluconate) for 6 wk, and blood samples were analyzed during various intervals. Plasma concentration of Zn increased
significantly (p < 0.001) in all the groups after 4 wk of supplementation and reached almost normal levels after 6 wk. Along
with the increase in Zn, there was a significant decrease(p < 0.001) in plasma Cu levels. There were no changes in the concentration of Fe during the supplementation period. The supplementation
was well tolerated by most subjects. The results of this pilot study indicate that Zn supplementation is a practical possibility
comparable to that of Fe supplementation in order to prevent marginal Zn deficiency in vulnerable groups in the general population
of developing countries. 相似文献
13.
Bülbül Hizel S Sanli C Bayar Muluk N Albayrak M Ozyazici A Apan A 《Biological trace element research》2008,124(2):129-134
The aim of this study was to investigate the effects of topotecan, a topoisomerase I-inhibiting anticancer agent, on hematologic
parameters and serum levels of trace elements. The study was conducted on three groups consisting of 16 and 18 rabbits in
the study groups and 15 rabbits in the control group. Rabbits in group I (n = 16) received high-dose topotecan intravenously (i.v.; 0.5 mg/kg once daily), while rabbits in group II (n = 18) received low-dose topotecan i.v. (0.25 mg/kg once daily) for 3 days. The 15 rabbits comprising the control group did
not receive topotecan. Serum samples were collected from each rabbit on the first day, before the treatment, and on the 15th
day of treatment. Erithrocytes, hemoglobin, white blood cell count, thrombocyte count, and trace elements such as selenium,
copper, lead, zinc, and cobalt were analyzed. Hemoglobin levels and erythrocyte counts were lower in both study groups than
in the control group. However, thrombocyte and leukocyte counts were similar in all three groups (p > 0.005). Serum trace element levels (copper, lead, zinc, and cobalt) did not differ significantly between groups. However,
serum selenium levels were significantly lower in both study groups than the control group (p < 0.001). The results revealed that topotecan treatment causes a decrease in erythrocyte counts and hemoglobin levels due
to bone marrow suppression, and these effects must be taken into account during treatment. In addition, selenium supplementation
might be helpful in cancer patients receiving topotecan to increase the effect of the chemotherapeutic agent. 相似文献
14.
Effect of zinc and melatonin supplementation on cellular immunity in rats with toxoplasmosis 总被引:1,自引:0,他引:1
Baltaci AK Bediz CS Mogulkoc R Kurtoglu E Pekel A 《Biological trace element research》2003,96(1-3):237-245
The effects of zinc (Zn) and/or melatonin supplementation on cellular immunity were investigated in rats infested with Toxoplasma gondii. Fifty Sprague-Dawley male rats were used for this study. All animals were fed a normal diet, ad libitum, containing 97 mg Zn/kg. They were divided into five experimental groups, as follows. Group I (n=10) received intraperitoneal injections of zinc sulfate at a dose of 3 mg/kg/d for 3 wk. Group II (n=10) received intraperitoneal injections of melatonin at a dose of 3 mg/kg/d for 3 wk. Group III (n=10) received intraperitoneal injections of zinc sulfate (3 mg/kg/d) and melatonin (3 mg/kg/d) for 3 wk. Group IV (n=10) was infested controls. Group V (n=10) was healthy controls. There were no differences in the percentage of CD3+ lymphocytes among all groups. For groups I–III,
the CD4+ and CD8+ ratios were higher than those of the groups IV and V controls (p<0.01). Similarly, the total lymphocyte ratios in groups I–III were higher than those of infested and healthy controls (p<0.01). The total lymphocyte ratios in group III were significantly higher than those of groups I and II (p<0.01). The plasma Zn levels in the supplemented groups were significantly higher than those of control groups IV and V (p<0.01). These results suggest that melatonin and/or Zn supplementation may activate cellular immunity by stimulating CD4+
and CD8+ production in infected rats with T. gondii. 相似文献
15.
Vedat Cinar Abdulkerim Kasim Baltaci Rasim Mogulkoc Mehmet Kilic 《Biological trace element research》2009,129(1-3):65-69
The effects of 4 weeks of calcium supplementation on free- and total testosterone levels were established in active and sedentary adult males at rest and exhaustion. Thirty healthy male athletes were equally divided into three study groups, as follows: Group 1—non-exercising subjects receiving 35 mg calcium/kg body weight; Group 2—subjects receiving 35 mg calcium/kg body weight undergoing training routines for 90 min/day, 5 days a week and Group 3—subjects undergoing training routines for 90 min/day, 5 days a week. The testosterone levels were determined before and after supplementation, at rest and following a hard training routine. The plasma free- and total testosterone levels increased at exhaustion before and after supplementation relative to resting values (p?<?0.05). This was also true when active subjects were compared to inactive subjects (p?<?0.05). Our results show that training results in increased testosterone levels in athletes and that the increase is greater if accompanied by calcium supplementation, which may be useful for increasing overall athletic performance. 相似文献
16.
Alfredo Cordova Francisco José Navas Jesús Fernando Escanero 《Biological trace element research》1993,39(1):13-20
This study evaluates the consequences of a session of intensive short-duration exercise and Zn supplementation on different
hematological variables. Forty male Wistar rats were divided into four groups (n=10): the first nonsupplemented, maintained at rest (R); the second nonsupplemented, undergoing exercise (E); the third supplemented
with Zn, kept at rest (ZnR); and the fourth supplemented with Zn, undergoing exercise (ZnE). Zinc supplements (200 ppm) were
given in drinking water. The exercise consisted of a single session of swimming until exhaustion. At rest, RBC, Hb, and Hto
fell (p<0.05), whereas red cell indices, MCV, and MCH rose (p<0.05) in +ZnR compared with R; MCHC remained unchanged (ZnR vs R). After exercise, RBC, Hb, and Hto increased significantly
in E and in ZnE compared with R and ZnR, respectively. In addition, RBC and Hb were lower (p<0.01) in ZnE compared with E; however, MCV and MCH were higher (p<0.05) in the group ZnE vs E. With respect to white blood cells—leukocytes (WBC), limphocytes (LYMPH), and neutrophiles (NEUT)—no
significant differences were observed between groups at rest (ZnR vs R). WBC and LYMPH increased significantly in E with respect
to the rest situation (E vs R), but this did not happen in supplemented animals (ZnE vs ZnR). Level of pH decreased after
exercise both in E and in ZnE, but the fall was lower in the latter. We believe that a single session of swimming until exhaustion
leads to an increase in RBC, Hb, and Hto without causing changes in MCV, MCH, and MCHC. On the other hand, Zn supplementation
leads to an increase of MCV and MCH, although they remain within normal levels. Furthermore, this supplementation produces
lower metabolic acidoses after exercise that leads to leukocyte stability. 相似文献
17.
The present study was performed to investigate the effects of strenuous exercise and calcium supplementation on cortisol and
adrenocorticotropic hormone levels in athletes at rest and exhaustion. Thirty male athletes, ages 17–21 years, were enrolled
in the 4-week study. They were divided into three groups as follows: group 1 (n = 10): training without supplementation; group 2 (n = 10): training and calcium supplemented, and group 3 (n = 10): calcium supplemented without training. Venous blood samples were obtained for determination of the hormones. One-month
supplementation with calcium does not influence the cortisol and adrenocorticotropic hormone in athletes, but strenuous exercise
results in a significant increase in their levels with or without supplementation (p < 0.05). 相似文献
18.
Abdulkerim Kasim Baltaci Hakki Gokbel Rasim Mogulkoc Nilsel Okudan Kagan Ucok Ihsan Halifeoglu 《Biological trace element research》2010,134(1):79-83
The objective of the present study was to determine the effects of exercise and zinc deficiency on some elements in rats.
Forty adult male Sprague–Dawley species male rats were allocated to four groups as follows: Group 1: control, Group 2: zinc-deficient,
Group 3: exercise in which exercise group fed with a normal diet, Group 4: zinc-deficient exercise, exercise group fed by
a zinc-deficient diet for 15 days. After the procedure ended, rats in groups 3 and 4 were exercised on the treadmill for 60 min
at a speed of 6 m/min until the exhaustion. The rats were decapitated 48 h after exercise together with their controls, and
blood samples were collected to determine copper (Cu), iron (Fe), magnesium (Mg), calcium (Ca), and phosphorus (P) levels.
The highest Cu and Fe values in the serum were obtained in group 2 (p < 0.01). The levels of these elements in group 4 were lower than those in group 2 and higher than the levels in groups 1
and 3 (p < 0.01). Serum Mg levels did not differ significantly between groups. Group 4 had the lowest serum Ca and P levels (p < 0.01). These same parameters in Group 2 were higher than those in group 4 but significantly lower than those in groups
1 and 3 (p < 0.01). There was no significant difference between Ca and P levels of groups 1 and 3. The results of the study indicate
that zinc deficiency adversely affects copper, iron, calcium, and phosphorus mechanisms and that these adverse effects much
more marked after an effort exercise. 相似文献
19.
Ozturk A Baltaci AK Mogulkoc R Oztekin E Sivrikaya A Kurtoglu E Kul A 《Biological trace element research》2003,94(2):157-166
The aim of the study was to investigate the effects of zinc deficiency and supplementation on lipid peroxidation and glutathione
levels in blood and in some tissues of rats performing swimming exercise. Forty adult male Sprague-Dawley rats were divided
into four groups: group 1, zinc-deficient consisted of swimming rats; group 2 consisted of zinc-supplemented swimming rats;
groups 3 and 4 were the swimming and nonswimming controls, respectively. The levels of malondialdehyde and glutathione were
measured after 4 wk of zinc-deficient or zinc-supplemented diet and 30 min of swimming exercise daily.
The erythrocyte glutathione levels of groups 2 and 4 were significantly higher than those of groups 1 and 3 (p<0.01). The plasma malondialdehyde level of group 1 was significantly higher than all other groups. The glutathione levels
in liver, kidney, striated muscle, and testes of group 2 were higher than in the other groups (p<0.01) and higher in kidney and striated muscle of group 3 than in groups 1 and 4 (p<0.01). The tissue malondialdehyde levels of striated muscle, liver, kidney, and testes of group 1 were significantly higher
than for all other groups (p<0.01). Our findings suggest that both swimming exercise and zinc deficiency result in an increase of lipid peroxidation in
tissues and that zinc supplementation prevents these alterations by the activation of the antioxidant system. 相似文献
20.
Koury JC de Oliveira CF Portella ES Oliveira AV Donangelo CM 《Biological trace element research》2005,107(3):201-211
The purpose of this study was to evaluate the effect of the resting period on hematological and copper-zinc-dependent antioxidant
indices in Brazilian elite judo athletes (n=7). Venous blood samples were collected after 24-h and 5-d periods of resting following a competition, with an interval of
30 d between collections. Two months prior to and during the study, each athlete received an individualized adequate diet.
Body composition was determined at both study periods. The following were analyzed: in whole blood, hemoglobin, hematocrit,
red cell count, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red cell
distribution width, and white cell count; in plasma, zinc, copper, iron, ceruloplasmin, and total iron-binding capacity; in
erythrocytes, metallothionein, copper/zinc superoxide dismutase, and osmotic fragility. Dietary intake and body composition
did not affect the biochemical measurements. A significant reduction in ceruloplasmin and superoxide dismutase activity was
found after 5 d compared to 24 h of resting. A significant correlation between erythrocyte metallothionein and red cell distribution
width was observed after 24 h of resting (r=−0.83, p=0.02) whereas positive correlations of metallothionein with hemoglobin, red cell count, and mean corpuscular hemoglobin concentration
were observed after 5 d of resting (r≥0.76, p≤0.05). Our results suggest that a longer resting period favors homeostatic adjustments in the erythrocyte population and
in the copper/zinc-dependent antioxidant system in elite judo athletes. 相似文献