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The mammalian Mediator complex 总被引:2,自引:0,他引:2
Conaway JW Florens L Sato S Tomomori-Sato C Parmely TJ Yao T Swanson SK Banks CA Washburn MP Conaway RC 《FEBS letters》2005,579(4):904-908
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Chang DC 《Behavioural processes》2006,71(2-3):211-225
Circadian clocks include control systems for organizing daily behavior. Such a system consists of a time-keeping mechanism (the clock or pacemaker), input pathways for entraining the clock, and output pathways for producing overt rhythms in behavior and physiology. In Drosophila melanogaster, as in mammals, neural circuits play vital roles in all three functional subdivisions of the circadian system. Regarding the pacemaker, multiple clock neurons, each with cell-autonomous pacemaker capability, are coupled to each other in a network. The outputs of different sets of clock neurons in this network combine to produce the normal bimodal pattern of locomotor activity observed in Drosophila. Regarding input, multiple sensory modalities (including light, temperature, and pheromones) use their own circuitry to entrain the clock. Regarding output, distinct circuits are likely involved for controlling the timing of eclosion and for generating the locomotor activity rhythms. This review summarizes work on all of these circadian circuits, and discusses the broader utility of studying the fly's circadian system. 相似文献
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The ins and outs of circadian timekeeping. 总被引:5,自引:0,他引:5
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