A conceptual contribution to battles in the brain

Badcock and Crespi have advanced the hypothesis that autism and schizophrenia are caused by imbalanced imprinting in the brain. They argue that an imbalance between the effects of paternally and maternally expressed genes on brain development results in either an extreme paternal (autism) or maternal brain (schizophrenia). In this paper their conceptual model is discussed and criticized since it presupposes an incoherent distinction between observable physical and hidden mental phenomena. An alternative model is discussed that may be more fruitful for investigating the possible role of imprinted genes in the development of social behaviour. The development of crying and reactive crying and behaviours necessary for collaborative action are discussed as a promising research area for understanding the effects of imprinted genes.     

Randomized controlled experiments in health and social sciences: Some conceptual issues

This brief article outlines some difficulties as well as benefits in conducting randomized controlled trials in social science settings especially in developing countries. Some of the historical developments are summarized and certain applications in health sciences are discussed from methodological and policy standpoints.     

Chilling injury: a plea for uniform terminology

Abstract This article proposes definitions for the terms now commonly applied to studies of both the molecular and cellular aspects of chilling injury. They are proposed with the intent of increasing the precision and clarity of communications on the subject and arc based on the present understanding and current hypotheses regarding the molecular events underlying the development of the visible symptoms of chilling injury.     

Horse versus machine: battles in the betting shop

Changes in regulation and taxation during the past decade have had a profound effect on the experience of betting in dedicated shops in the United Kingdom. This article explores how betting shop customers and staff in London have responded to the introduction of gambling machines depicting roulette and other casino‐type games in an environment that was traditionally dedicated to betting on horse and dog racing. The rise of machine gambling has been presented as a transition from ‘social’ to ‘asocial’ forms of gambling by researchers working in the UK, Las Vegas, and Australia. Traditional bettors and betting shop staff also present betting and machine play as discrete and value them differently. I show that while some of the experiential qualities of machine play observed elsewhere have been replicated in shops, the differences between traditional betting and machine play are overstated, for structural reasons. Traditional bettors and staff are interested in distinguishing their activities from those of newcomers. Responses to new gambling media in betting shops are socially, as well as experientially, mediated, a crucial insight for the wider study of gambling and gambling regulation.

Résumé

L'évolution de la réglementation et de la taxation des paris a eu depuis une dizaine d'année de profonds effets sur l'expérience des parieurs dans les officines du Royaume‐Uni. Le présent article étudie la réaction des clients et du personnel de bureaux de paris londoniens à l'apparition des machines proposant des jeux de roulette et autres jeux de casino dans un environnement traditionnellement dévolu aux paris sur les courses de chevaux et de chiens. Au Royaume‐Uni, à Las Vegas et en Australie, des chercheurs ont présenté l'essor des machines de jeux comme le passage de formes de jeu « sociales »à d'autres « asociales ». Les parieurs traditionnels et les employés des bureaux de paris considèrent eux aussi les paris et les jeux sur machines comme deux activités distinctes et de valeur différente. L'auteure montre ici qu'une partie des qualités de l'expérience du jeu sur machines observées ailleurs se retrouvent dans les bureaux de paris, mais que les auteurs ont exagéré les différences entre paris traditionnels et jeux sur machines, pour des raisons structurelles. Les parieurs traditionnels et les employés ont intérêt à distinguer leurs activités de celles des nouveaux venus. La réponse aux nouveaux modes de jeu dans les bureaux de paris, médiée socialement mais aussi par l'expérience, est très instructive pour l'étude plus large des jeux de paris et de leur réglementation.     

The terminology problem for T cells: a discussion paper

The school of thought that owes allegiance to Ludwig Wittgenstein teaches that language conditions perceptions. When we use the term ''cytotoxic T lymphocyte'' or ''helper T cell'' we tend to orientate our own thinking processes, and those of listeners or readers, down particular paths. Part of the problem is that we are often describing cell populations by functions that may either be a property of only a proportion of those that are being assayed, or are simply inferred from the expression of various cell-surface markers. The consequence can be a measure of confusion that might be avoided if we could communicate with greater clarity. Is it possible to achieve a better terminology that will be accepted generally? The following are some examples of why there may be some value in thinking about this.     

Inconsistent use of terminology in animal developmental toxicology studies: a discussion

The usage and meaning of terminology in teratology studies varies from laboratory to laboratory. This variability often causes confusion on the part of those reading and attempting to interpret the results published in papers and technical reports. Terms often used to categorize individual findings include embryotoxicity, fetotoxicity, teratogenicity, and maternal toxicity. One reason for the variability in the meaning of these words may be the inconsistency in the categorization of data leading up to the interpretation of the results. A more standardized use of these terms would allow more consistent interpretation and comparison of the data presented in teratology reports. This communication discusses some of these inconsistencies and offers suggestions that might help improve the situation.     

Developments in industrially important thermostable enzymes: a review

Cellular components of thermophilic organisms (enzymes, proteins and nucleic acids) are also thermostable. Apart from high temperature they are also known to withstand denaturants of extremely acidic and alkaline conditions. Thermostable enzymes are highly specific and thus have considerable potential for many industrial applications. The use of such enzymes in maximising reactions accomplished in the food and paper industry, detergents, drugs, toxic wastes removal and drilling for oil is being studied extensively. The enzymes can be produced from the thermophiles through either optimised fermentation of the microorganisms or cloning of fast-growing mesophiles by recombinant DNA technology. In this review, the source microorganisms and properties of thermostable starch hydrolysing amylases, xylanases, cellulases, chitinases, proteases, lipases and DNA polymerases are discussed. The industrial needs for such specific thermostable enzyme and improvements required to maximize their application in the future are also suggested.     

Sexual arousal in men: a review and conceptual analysis

Sexual arousal is an emotional/motivational state that can be triggered by internal and external stimuli and that can be inferred from central (including verbal), peripheral (including genital), and behavioral (including action tendencies and motor preparation) responses. This article, while focusing on sexual arousal in men, provides a conceptual analysis of this construct, reviews models of sexual arousal, and discusses the usefulness of perspectives derived from motivation and emotion research in improving our understanding of its determinants and behavioral correlates. In this, it considers the role of genital feedback in men's subjective sexual arousal and the connections between sexual arousal and sexual desire. Future research and definitions may increasingly focus on its central integrative functions (as opposed to its input and output characteristics). Yet, the study of sexual arousal can be expected to continue to benefit from the measurement of its genital, verbal, and behavioral components. Instances of discordance between response components suggest that they are, at least in part, under the control of different mechanisms, and it is proposed that a better understanding of sexual arousal will prove contingent on a better understanding of such mechanisms and the conditions under which they converge and diverge.     

Parasite immune evasion: a momentous molecular war

Current research in immunology shows that parasite evasion of host immunity is ubiquitous and involves a wide range of molecular mechanisms. Furthermore, immune evasion appears to generate a large spectrum of pathogenic effects, such as cytokine storms and inflammation. Understanding the relationships between the beneficial effects of immune evasion and its pathogenic consequences therefore provides a new framework to reassess many of the core questions of the evolutionary ecology of host-parasite interactions, such as the evolution of virulence, immune defence strategies, infective dose and host specificity, and to address questions that thus far could not be satisfactorily analysed.     

Application of metabolome data in functional genomics: a conceptual strategy

A gene with yet unknown physiological function can be studied by changing its expression level followed by analysis of the resulting phenotype. This type of functional genomics study can be complicated by the occurrence of 'silent mutations', the phenotypes of which are not easily observable in terms of metabolic fluxes (e.g., the growth rate). Nevertheless, genetic alteration may give rise to significant yet complicated changes in the metabolome. We propose here a conceptual functional genomics strategy based on microbial metabolome data, which identifies changes in in vivo enzyme activities in the mutants. These predicted changes are used to formulate hypotheses to infer unknown gene functions. The required metabolome data can be obtained solely from high-throughput mass spectrometry analysis, which provides the following in vivo information: (1) the metabolite concentrations in the reference and the mutant strain; (2) the metabolic fluxes in both strains and (3) the enzyme kinetic parameters of the reference strain. We demonstrate in silico that changes in enzyme activities can be accurately predicted by this approach, even in 'silent mutants'.     

Effective sizes of macroparasite populations: a conceptual model

Effective population size (N(e)) is a crucial parameter in evolutionary biology because it controls genetic drift and the response to selection. Thus, N(e) influences evolutionary processes in parasites, such as speciation, host-race formation, local host adaptation and the evolution of drug resistance. However, N(e) is a parameter that is ignored almost completely in parasitology. Our goal is to provide a conceptual framework that facilitates future studies of the N(e) of macroparasites. The key feature of macroparasite populations is that breeders are subdivided into infrapopulations. We use a model of subdivided breeders to show how some basic demographic factors that control N(e) in all species could be estimated for macroparasites. An important conclusion is that several features of parasite life cycles probably function in concert to reduce N(e) below that expected in a single free-living population of equivalent census size.     

Avian community composition in isolated forest fragments: a conceptual revision

Forest birds do not respond equally to effects of deforestation: some species are absent from small fragments, some species increase in relative abundance in isolated fragments, while others are not present in fragments that appear to be of sufficient quality and area to meet their ecological requirements. Mechanisms currently associated with forest fragmentation are insufficient to predict how populations of individual species respond to deforestation. Based on published data representing 573 forest fragments, we examined the effects of deforestation on the relative abundance of birds in isolated forest fragments. We tested the prediction that species exhibit differential responses to deforestation based on their mean body mass. We found that forest bird communities in small, isolated forests can be generally predicted based on the home range needs and the average mass of individual bird species; mass may be an indicator of competitive abilities. Large and small species are not present and medium-sized species may increase in relative abundance in these forests. The limitations and implications of this pattern are discussed.