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Metabolism of polycyclic compounds. 25. The metabolism of anthracene and some related compounds in rats 总被引:2,自引:2,他引:0 下载免费PDF全文
P. Sims 《The Biochemical journal》1964,92(3):621-631
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Metabolism of polycyclic compounds. The metabolism of 9,10-epoxy-9,10-dihydrophenanthrene in rats 总被引:1,自引:1,他引:0 下载免费PDF全文
1. The main products of the metabolism of 7,12-dimethylbenz[a]anthracene by rat-liver homogenates are the isomeric monohydroxymethyl derivatives. The syntheses of these compounds are described. 2. Two phenolic products and two dihydrodihydroxy compounds were formed, but none of these appeared to have been formed by hydroxylation at the `K region'. There was little evidence for the formation of a glutathione conjugate of the hydrocarbon. 3. The monohydroxymethyl derivatives are products of the hydroxylation of the hydrocarbon in the ascorbic acid–Fe2+–oxygen model hydroxylating system. 相似文献
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Metabolism of polycyclic compounds. The metabolism of 1,4-epoxy-1,4-dihydronaphthalene in rats 下载免费PDF全文
P. Sims 《The Biochemical journal》1965,95(3):608-611
1. 1,4-Epoxy-1,4-dihydronaphthalene is converted by rats into 1,4:2,3-diepoxy-1,2,3,4-tetrahydronaphthalene, which was isolated from the urine. The synthesis of the diepoxide is described. 2. The monoepoxide also yielded a compound that is believed to be 1,4-dihydro-1,4-dihydroxynaphthalene, but no corresponding mercapturic acid was detected. A number of unidentified metabolites of the monoepoxide were detected that appear to arise by the hydroxylation of the diepoxide. 3. The monoepoxide is converted into the diepoxide by a rat-liver microsomal system. 4. 1,4-Epoxy-1,4-dihydronaphthalene does not appear to be an intermediate in naphthalene metabolism. 相似文献
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1. The main products of the metabolism of 7,12-dimethylbenz[a]anthracene by rat-liver homogenates are the isomeric monohydroxymethyl derivatives. The syntheses of these compounds are described. 2. Two phenolic products and two dihydrodihydroxy compounds were formed, but none of these appeared to have been formed by hydroxylation at the `K region''. There was little evidence for the formation of a glutathione conjugate of the hydrocarbon. 3. The monohydroxymethyl derivatives are products of the hydroxylation of the hydrocarbon in the ascorbic acid–Fe2+–oxygen model hydroxylating system. 相似文献
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