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1.
Matti Tolonen Seppo Sarna Markku Halme Seppo E. J. Tuominen Tuomas Westermarck Ulla-Riitta Nordberg Mirja Keinonen Jaap Schrijver 《Biological trace element research》1988,17(1):221-228
An “anti-oxidant cocktail” consisting of betacarotene, vitamins B6, C, E, zinc, and selenium or corresponding placebos were given for one y as daily dietary supplements to 45 elderly residents
of a nursing home. Initially, the serum TBA reactant levels were higher (2.7±0.7 μmol/L) than those of an ad hoc control group
of healthy younger adults (2.3±0.6 μmol/L),p<0.01. After three mo supplementation, the levels among the verum elderly had decreased to 2.2±0.6 μmol/L, and they remained
at this lower level until the end of the study period, whereas the placebo group showed no change.
A significant inverse correlation (r=−0.428,p<0.01) existed between the concentrations of serum TBA reactants and whole blood selenium (B-Se), but only B-Se levels above
200 μg/L were associated with a decrease in serum lipid peroxides. Serum alpha-tocopherol concentration also correlated inversely
with serum TBA reactants but this correlation (r=−0.273,p<0.76) was not as strong as that of B-Se.
Deficient vitamin B6 status, in biochemical terms, was observed in 25% of the elderly; a daily supplement of 2 mg B6 fully cured all cases of deficiency. The verum group improved slightly in several psychological tests, whereas subjects on
placebo remained unchanged or deteriorated during the follow-up period. Clinical amelioration among the verum subjects was
reported by the nurses; no toxic side effects were reported. In conclusion, the elderly benefited biochemically and clinically
of dietary antioxidant supplements. 相似文献
2.
Lennart Hardell Marit Danell Carl-Axel Ängqvist Stefan L. Marklund Mats Fredriksson Anna-Lena Zakari Arne Kjellgren 《Biological trace element research》1993,36(2):99-108
Plasma selenium and glutathione peroxidase in erythrocytes were analyzed in a case-control study encompassing 441 cases with
breast cancer and 191 controls with benign breast disease. No difference in mean serum selenium level between cases and controls
on supplementary selenium intake was seen. If only individuals without supplementary intake, 278 cases and 135 controls, were
considered a preventive effect was found increasing with selenium level. This finding was significant among women 50 years
old or more with Mantel-Haenszel odds ratio=0.16 for individuals with serum selenium >1.21 μmol/L. Also for subjects with
serum selenium in the range 1.00–1.21 μmol/L a significant preventive effect was seen with odds ratio=0.38. For women under
50 years of age a nonsignificant preventive effect was seen. Glutathione peroxidase in erythrocytes did not correlate well
with serum selenium and was not a marker for the risk of breast cancer. 相似文献
3.
The concentrations of cadmium, lead, selenium, and zinc in blood and seminal plasma were determined in 76 Singapore males.
Except for zinc, the concentrations were generally higher in blood than in seminal plasma (cadmium, 1.31 μg/L vs 0.61 μg/L;
lead, 82.6 μg/L vs 12.4 μg/L, and selenium, 163.6 μg/L vs 71.5 μg/L). The mean concentration of zinc in seminal plasma was
more than 30 times higher than in blood (202 mg/L vs 6.2 mg/L). Significant positive correlations were found between the concentrations
in blood and seminal plasma for the two essential trace elements: selenium (r=0.45,p<0.001) and zinc (r=0.25,p<0.05). However, no relationships were found between the concentrations in blood and seminal plasma for two toxic metals (cadmium
and lead). Significant inverse correlations were observed between Cd and Zn (r=−0.40,p<0.01), and Pb and Se (r=−0.32,p<0.05) in blood, whereas significant positive correlations were noted between Cd and Se (r=0.45,p<0.01), Cd and Zn (r=0.35,p<0.05), and Se and Zn (r=0.57,p<0.001) in seminal plasma. The physiological significance of these relationships are also discussed in this paper. 相似文献
4.
Jerome Honnorat Michele Accominotti Christiane Broussolle Andree-Carole Fleuret Jean-Jacques Vallon Jacques Orgiazzi 《Biological trace element research》1992,32(1-3):311-316
Zinc status was assessed in 53 diabetic patients: 18 insulin-dependent diabetic patients (IDDM), 22 noninsulin-dependent diabetic
patients (NIDDM) treated with oral antidiabetic agents, and 13 insulin-treated, noninsulin-dependent diabetic patients (IRDM).
Plasma zinc concentrations were in the usual range for healthy subjects in these three groups (15.3±0.9 μmol/L). Urinary zinc
excretions were elevated in the IDDM group (18.3±4.1 μmol/24 h;p<0.01 vs normal) and in the NIDDM group (17.5±3.5 μmol/24 h;p<0.01 vs normal), but normal in the IRDM group (11.3±2.4 μmol/24 h). In 14 NIDDM patients treated with transient continuous
sc insulin injections, urinary zinc decreased from 16.5±2.2 μmol/24 h before insulin treatment to 11.5±0.3 μmol/24 h after
insulin treatment without any modification in plasma zinc concentrations. 相似文献
5.
Feridun Kosar Ibrahim Sahin Nusret Acikgöz Yuksek Aksoy Zehra Kucukbay Sengul Cehreli 《Biological trace element research》2005,107(1):1-9
It is known that certain trace elements can affect various heart diseases. In this study, we aimed to evaluate the changes
in concentrations of certain serum trace elements in patients with chronic rheumatic heart disease (RHD). Serum analysis of
selenium (Se), zinc (Zn), and copper (Cu) trace elements was assayed by atomic absorption spectrophotometry. RHD patients
had significantly lower serum concentrations of Se and Zn than control subjects (p<0.05 and p<0.001, respectively). However, the serum Cu concentration was significantly higher in RHD patients than in controls (1.93±0.59
μg/L vs 1.06±0.29 μg/L; p<0.001). Similarly, the Cu/Zn ratio in RHD patients was higher than in control subjects (4.70±0.92 vs 1.68±0.45; p<0.001). Additionally, no significant correlation was found among these trace element concentrations and the functional capacity
classes (p>0.05). RHD patients had decreased serum Se and Zn element concentrations and increased serum Cu element concentration. We
suggest that Se and Zn deficiency might be contributory factors in the development of rheumatic heart disease, and a high
Cu concentration and a high Cu/Zn ratio might reflect an ongoing inflammatory process in this disease. 相似文献
6.
W. -C. Wang A. -L. Mäkelä V. Näntö P. Mäkelä 《Biological trace element research》1995,47(1-3):355-364
The effect of increased selenium uptake on serum selenium in diabetic children was investigated during the first 9 yr of the
Finnish nationwide selenium fertilization program, which started in 1984. Serum selenium concentrations were followed in 237
diabetic children (mean age 8.1 yr) and 214 controls from 1984 to 1992. The control group consisted of 107 siblings of the
diabetics and of 107 other healthy children of corresponding age groups. Selenium was determined by direct electrothermal
atomic absorption spectrophotometry. The effect of the increased uptake was seen in both diabetic and in control persons.
Before the autumn of 1985, diabetic patients had significantly higher serum selenium levels than their siblings or the other
healthy controls. Toward the end of year 1987, this difference had disappeared. After that, serum selenium levels continued
to increase until the year 1990. In 1990 the mean selenium serum level of diabetic patients was 1.36 μmol/L and that of controls
1.33 μmol/L.
The duration of diabetes did not have any effect on selenium serum levels. Slightly higher serum selenium in new diabetic
patients before the start of therapy was explained by the dehydration state.
The patients who were younger than 3 yr had slightly lower selenium serum levels when compared with older age groups. This
difference was observed, however, only during the first 3 yr of the study. After that, when the selenium intake increased
in general, no age-dependent differences were found anymore. There were no significant differences in serum selenium levels
between males and females in either diabetic patients or in controls. 相似文献
7.
Van Biervliet S Van Biervliet JP Robberecht E 《Biological trace element research》2006,112(3):205-211
There is no consensus whether zinc (Zn) supplementation is necessary in cystic fibrosis (CF). For assessment of the Zn status,
serum Zn concentration is the only easy available method. It is, however age dependent. We compare the serum Zn levels of
CF patients with earlier reported normal values. Serum Zn was determined in all new diagnosed CF patients and a second time
1 yr later. Data concerning fat-soluble vitamin status, cholesterol, albumin, pancreatic insufficiency, and genotype were
collected. Thirty-two patients, median age of 1.21 yr, were included. Four were pancreatic sufficient. The median Zn concentration
at diagnosis was 10.7 μmol/L (5–21.4), with a significant increase 1 yr later (median: 12.1 μmol/L [7,803–16,1]). An association
of serum Zn with vitamin A (p<0.03) and with vitamin E (p<0.02) was observed. Compared to age-matched healthy controls, there is no significant difference in serum Zn concentration
either at diagnosis or 1 yr later. Although it was demonstrated that steatorrhoea causes Zn loss, the serum Zn concentration
in CF is not significantly different from healthy controls. The relation with vitamin A and E points to the increased losses
by steatorrhoea. Therefore, Zn supplementation is advised in persisting steatorrhoea. 相似文献
8.
Markus P. Look Jürgen K. Rockstroh Govind S. Rao Karl A. Kreuzer Ulrich Spengler Tilman Sauerbruch 《Biological trace element research》1997,56(1):31-41
Serum selenium levels were determined cross-sectionally in 57 HIV-infected patients who were classified according to the Centers
for Disease Control (CDC) 1993 classification system. Mean serum selenium levels were lower in CDC stage II (58.7±12.2 μg/L;p<0.01;n=18) and stage III (47.6±11.3 μg/L;p<0.01;n=19) HIV-infected patients, than in healthy subjects (80.6±9.6 μg/L;n=48) and stage I patients (73.6±16.5 μg/L;n=20). Serum selenium levels were positively correlated with CD4 count, CD4/8 ratio, hematocrit, and serum albumin (r=0.42;r=0.39;r=0.48; andr=0.45;p<0.01, respectively) and inversely with serum levels of thymidine kinase (r=−0.49;p<0.01;n=49) and β2-microglobulin (r=−0.46;p<0.001;n=49). In addition, serum selenium levels in 20 randomly selected AIDS-free individuals (CDC I:n=10; CDC II:n=10) were inversely correlated with serum concentrations of interleukin-8 (IL-8) and soluble tumor necrosis factor receptors
(sTNFR) types I and II. There was no correlation with serum immuneglobulin A and total serum protein levels. The results show
that the progressive deprivation of serum selenium in HIV-infection is associated with loss of CD4+-cells and with increased levels of markers of disease progression and inflammatory response. 相似文献
9.
Eberhard Kauf Horst Dawczynski Gerhard Jahreis Evelyn Janitzky Klaus Winnefeld 《Biological trace element research》1994,40(3):247-253
The effectiveness of a peroral sodium selenite therapy (115 μg Se/m2 BSA/d) administered to cystic fibrosis patients (n=32) could after three months be identified in a significant serum selenium increase (0.69→0.96 μmol/L), a significant malondialdehyde
decrease (2.72→1.64 μmol/L), as well as in a significant serum vitamin E increase (4.31→5.72 μg/mL) Parallel to that, a serum
T3 increase as well as a highly significant decrease in the serum T4/T3-ratio were found, too, which point to improved peripheral T4→T3 conversion during selenium medication. Type-I-iodothyronine-5′-deiodinase has recently been identified as a specific selenoenzyme.
In the case of congenital hypothyroidism (n=37) application of sodium selenite in the above specified dosage yielded a mean serum selenium increase (0.87→1.12 μmol/L),
a not significant T3 increase (2.57→2.61 nmol/L) as well as a not significant TSH decrease (5.34→4.49 mIU/L) without an expected T4 decrease. With the serum lipids, however, a lowering of total cholesterol (4.85→4.53 mmol/L) simultaneous with a mean increase
in HDL-cholesterol (1.52→1.66 mmol/L) as well as a decrease in LDL-cholesterol (2.93→2.52) could be observed. We view the
reduction of the atherogenic serum lipid constellation in the course of selenium medication as an expression of increased
thyroid-hormone efficacy. 相似文献
10.
Hee Y. Paik Hyojee Joung Joo Y. Lee Hong K. Lee Janet C. King Carl L. Keen 《Biological trace element research》1999,69(1):45-57
The present study focused on whether serum extracellular superoxide dimutase (EC-SOD) activity can be used as a functional
indicator of marginal zinc deficiency in humans. Subjects in this study were 444 healthy adults over 30 yr of age living a
normal rural life in Kyunggi province, Korea. The mean dietary zinc intake of subjects obtained from one 24-h recall was 6.41
± 4.35 mg and the average serum zinc concentration of the subjects was 11.06 ± 2.44 (μmol/L. Subjects were divided into three
groups by serum zinc concentrations: adequate (serum zinc >10.7 (μmol/L), low (serum zinc 9.0–10.7 μmol/L), and very low (serum
zinc <9.0 μmol/L) groups. A total of 50 subjects were selected from the three groups for analysis of EC-SOD activities. The
EC-SOD activity of subjects increased with increasing serum zinc concentrations, and the activities of the three groups were
significantly different as indicated by the Kruskal-Wallis test (p = 0.0239). Also, serum EC-SOD activities were significantly
correlated with serum zinc concentrations (r = 0.289,p = 0.04). Serum EC-SOD activities, however, were not significantly correlated to the dietary zinc intakes. In conclusion,
these results show that EC-SOD activities are decreased in subjects with low serum zinc concentrations and suggest that EC-SOD
activity may be a functional indicator of zinc nutritional status in humans. 相似文献
11.
Letsiou S Nomikos T Panagiotakos D Pergantis SA Fragopoulou E Antonopoulou S Pitsavos C Stefanadis C 《Biological trace element research》2009,128(1):8-17
The trace element selenium is an essential micronutrient for human health and its low levels in serum are implicated in the
pathogenesis of several chronic diseases. Therefore, the determination of total selenium in serum may contribute to the assessment
of the health and nutritional status of certain populations. The objective of the present work was to determine total selenium
in the serum of 506 healthy volunteers that participated in the ATTICA study. Selenium was determined in serum by using the
technique of inductively coupled plasma mass spectrometry. The mean serum selenium concentration was determined to be 91.8 ± 33.7 μg/L
(N = 506); 87.6% of women and 88.5% of men had serum selenium concentration below 125 μg/L, the cutoff considered to be required
for optimal glutathione peroxidase activity. No association was found between serum selenium levels and the gender of the
participants while a significant decline of selenium with age (p < 0.0001) was observed. According to our results, no anthropometric, lifestyle, nutritional, or biochemical indices were
able to affect the association between serum selenium and age. This result may indicate that other factors such as selenium
distribution as well as retention may be affecting the relationship between serum selenium and age. 相似文献
12.
Gurkan F Atamer Y Ece A Kocyigit Y Tuzun H Mete M 《Biological trace element research》2004,100(2):97-104
Thirty-four infants with acute bronchiolitis and 25 age-matched healthy controls were enrolled to investigate the possible
relationship between serum malondialdehyde (MDA) and selenium (Se) levels and the occurrence and severity of acute bronchiolitis
in children. Serum samples were taken for serum Se and MDA measurements, and the clinical score was assessed at admission.
Blood was taken again from the children with bronchiolitis at 2 mo after discharge from the hospital. Mean serum MDA levels
were significantly higher in patients with acute bronchiolitis than at the postbronchiolitis stage and the controls (4.2±2.5nmol./L,
1.4±0.8 nmol/L, and 0.7±0.2 nmol/L, respectively [p<0.001]). Infants with bronchiolitis had lower mean serum Se levels at the acute stage than after 2 mo (31.7±28.9μg/L versus
68.4±26.4 μg/L, p<0.05, respectively); both of which were significantly lower than the control group measurements (145.0±21.9 μg/L) (p<0.001). There was a negative correlation between serum MDA and Se levels in the patient group (=−0.85, p<0.001). The age of the patient, child's immunization status, parental smoking habit, and family crowding index were not correlated
with serum Se, MDA levels, or clinical score at admission.
In conclusion, increased MDA levels and impaired Se status demonstrate the presence of possible relationship of these parameters
with pathogenesis of acute bronchiolitis, and antioxidant supplementation with Se might be thought to supply a beneficial
effect against bronchiolitis. 相似文献
13.
Hawkes WC Richter BD Alkan Z Souza EC Derricote M Mackey BE Bonnel EL 《Biological trace element research》2008,122(2):107-121
The essential nutrient selenium is required in microgram amounts [recommended dietary allowance (RDA) = 55 μg/day, 699 nmol/day]
and has a narrow margin of safety (upper tolerable intake limit = 400 μg/day, 5 μmol/day). We conducted a randomized placebo-controlled
study of high-selenium yeast, the form used in most supplements (300 μg/day, 3.8 μmol/day), administered to 42 free-living
healthy men for 48 weeks. Dietary intakes of selenium, macronutrients, and micronutrients were not different between groups
and did not change during the study. Supplementation more than doubled urinary selenium excretion from 69 to 160 μg/day (876
to 2,032 nmol/day). Urinary excretion was correlated with recent selenium intake estimated from 3-day diet records: urinary
selenium excretion = 42 μg/day (533 nmol/day) + 0.132 × dietary selenium intake, p < 0.001. Dietary selenium intake was not significantly correlated with the other indicators of selenium status, presumably
because urinary selenium excretion reflected recent intake, and tissue selenium was homeostatically controlled. After 48 weeks
of supplementation, plasma selenium was increased 60% from 142 to 228 μg/l (1.8 to 2.9 μmol/l), and erythrocyte selenium was
approximately doubled from 261 to 524 μg/l (3.3 to 6.6 μmol/l). Selenium concentrations increased more modestly in hair (56%)
and platelets (42%). Platelets were the only blood component in which glutathione peroxidase activity was significantly related
to selenium content. Selenium levels decreased rapidly after the end of supplementation, and there were no significant differences
in selenium status indicators between groups by week 96. The absorption, distribution, and excretion of selenium from high-Se
yeast were similar to selenium in foods. 相似文献
14.
Ozkaya M Sahin M Cakal E Gisi K Bilge F Kilinc M 《Biological trace element research》2009,128(2):144-151
The present study was conducted to evaluate the serum selenium levels in first-degree relatives of diabetic patients (FDR)
according to controls. Insulin resistance, serum lipid levels, inflammation markers, and blood pressure were also studied
in these patients. Serum levels of selenium in FDR were significantly lower than control group (74.65 ± 5.9 vs 88.7 ± 8.7 μg/dl,
p < 0.0001). HsCRP, HOMA-IR, insulin, homocysteine levels were significantly higher in FDR according to the control group (1.32 ± 0.9
vs 0.63 ± 0.4 mg/dL, p < 0.0001; 2.07 ± 0.84 vs 1.51 ± 0.69, p < 0.0001; 9.26 ± 3.8 vs 6.8 ± 2.98 μU/MI, p < 0.0001; 15.7 ± 7.4 vs 11.5 ± 5.1 μmol/L, p < 0.0001, respectively). There was significant correlation between selenium levels and hsCRP (r = − 0.450, p < 0.0001). There was also weak significant correlation also between HOMA-IR and selenium levels (r = −0.227, p = 0.003). There was a correlation between systolic blood pressure and BMI (r = 0.365, p < 0.0001). But there was no correlation between selenium levels and blood pressure or other parameters. HsCRP, HOMA-IR, homocysteine
levels in individuals with selenium levels < 80 μg/L (n = 78) was significantly higher than hsCRP HOMA-IR, homocysteine levels in individuals with selenium levels ≥ 80 (n = 91; 1.23 ± 0.98 vs 0.81 ± 0.76 mg/dL, p < 0.003; 1.99 ± 0.88 vs 1.64 ± 0.74, p < 0.005; 15.0 ± 7.6 vs 12.9 ± 5.7 μmol/L, p < 0.049, respectively). Selenium deficiency may contribute to cardiovascular disease risk in FDR. 相似文献
15.
Gürgöze MK Olçücü A Aygün AD Taskin E Kiliç M 《Biological trace element research》2006,111(1-3):23-29
In the present study, the serum and hair levels of zinc, selenium, and copper were determined in children with iron-deficiency
anemia (IDA). A total of 52 anemic children aged 1–4 yr constituted the study group. Fortysix healthy children acted as controls.
The copper and zinc levels were measured with an atomic absorption spectrophometer. Serum and hair selenium was determined
by a spectroflourometric method. The serum zinc and selenium concentrations in the IDA group were found to be significantly
lower and serum copper significantly higher than those in the controls (p<0.05). Lower iron, zinc, and selenium concentrations (p<0.001) but not copper were found in hair (p>0.05). 相似文献
16.
Two-wk-old broiler chicks were inoculated via crop intubation withEimeria acervulina at two doses: 105 or 106 sporulated oocysts/bird or withEimeria tenella at a dose of 105 sporulated oocysts/bird. Serum and liver samples were collected on days 3 and 6 post-inoculation (PI). There were no significant
changes in serum or liver zinc, copper, and iron concentrations in any of the infected groups by 3 d PI. However, on d 6,
PI serum protein was significantly reduced in all of the infected groups compared to their pair-fed controls. The chicks infected
withE. tennella had significantly reduced serum zinc (1.20 vs 1.77 μg/mL) and iron (0.44 vs 1.28 μg/mL) concentrations and significantly
elevated serum copper (0.28 vs 0.17 μg/mL) and ceruloplasmin levels (20.33 vs 11.11 μg/mL) compared to their pair-fed counterparts.
Those chicks infected withE. acervulina (106 oocysts/bird) exhibited significantly reduced serum iron concentration by 6 days PI (0.90 vs 1.14 μg/mL). Liver zinc was
significantly increased in the chicks infected withE. tenella (349 vs 113 μg/g dry liver wt), as was copper (24 vs 19 μg/g), whereas liver iron concentration was significantly reduced
(172 vs 243 μg/g) compared to pair-fed controls. At both dose levels, the chicks infected withE. acervulina exhibited a significant reduction in liver iron by 6 d PI. Hepatic cytosol metals generally reflected whole tissue levels.
Metallothionein (MT)-bound zinc was significantly elevated in the chicks infected withE. tenella. Iron bound to a high molecular weight, heat-stable protein fraction (presumably cytoplasmic ferritin) was significantly
reduced in chicks infected withE. acervulina, as well as those infected withE. tenella. Collectively, the changes in serum zinc, copper, and iron concentrations, as well as the changes in hepatic zinc and MT-zinc
concentrations in the chicks infected withE. tenella were similar to changes evoked during an acute phase response to infection. It is possible that a secondary bacterial infection
or inflammation stemming from erosion of the lining of the cecum may play a role in the response of trace element metabolism
to theE. tenella infection.
Mentions of a trademarkr, proprietary product or specific equipment does not consitute a guarantee or warranty by the US Department
of Agriculture and does not imply its approval to the exclusion of other products. 相似文献
17.
The effects of selenium, zinc, iron, chromium, and lead on telomere lengths of human cells have not been investigated. This
article adopted flow cytometry and fluorescence in situ hybridization to investigate the impact of different elements on cellular apoptosis and telomere lengths of human hepatocytes
L-02 and hepatoma cells SMMC-7721. Results showed that these trace elements under the following dosages did not have remarkable
effect on cellular apoptosis. However, sodium selenite at doses of 0.5 and 2.5 μmol/L significantly extended the telomere
length of hepatocytes L-02; 0.5 μmol/L lead acetate remarkably shortened the telomere length of L-02 cells; 80 μmol/L zinc
sulfate, 20 μmol/L ferric chloride, and 200 μmol/L chromic chloride only had slight impact on the telomere length, respectively.
Regarding hepatoma cells SMMC-7721, sodium seleite at 0.5 and 2.5 μmol/L had little impact on the telomere length; 80 μmol/L
zinc sulfate significantly accelerated the loss of telomere length, whereas 20 μmol/L ferric chloride, 200 μmol/L chromic
chloride, and 0.5 μmol/L lead acetate remarkably extended the telomere lengths, respectively. The results revealed differential
effects of each trace element on the life-span of human hepatocytes and hepatoma cell lines, which suggested further research
on somatic hepatocytes and hepatoma in vivo. 相似文献
18.
The combined effects of vitamin E and selenium were studied in native Anatolian horses subject to strenuous exercise. The
concentrations of copper, zinc, iron, calcium, potassium, and magnesium were determined in serum by atomic absorption spectrometry
in two study groups (n = 25 each), one of which served as untreated controls. After exercising the horses by running 1,500 m in about 7 min, only
the copper level and the copper/zinc ratio significantly increased (p < 0.05), but the concentrations of calcium, potassium, iron, and magnesium remained unchanged. In horses treated with vitamin
E and selenium, the calcium and potassium levels decreased to levels lower than those of untreated controls before and after
exercise. The iron levels were not changed by exercise or treatment alone but increased when the horses had been supplemented
and exercised. The copper level and the copper/zinc ration increased as a result of exercise in both treated and untreated
horses. These changes suggest that supplementation with vitamin E and selenium had an important effect on the serum concentrations
of calcium, potassium, copper, iron, and the copper/zinc ratio. 相似文献
19.
Hiroshi Koyama Chiho Watanabe Hiroshi Satoh Hiroaki Hosokai Shizuo Tamura 《Biological trace element research》1995,50(1):33-42
Several studies have suggested that selenium serum levels may be associated with serum lipids and apolipoproteins. In the
present study, 99 clerical workers aged 40–49 yr were selected based on their drinking and smoking habits. The serum concentration
of selenium was not affected by these lifestyle factors. The regular drinkers had raised serum high-density lipoprotein cholesterol,
apo A-I, and apo A-II concentrations. Correlation analysis showed that serum selenium was positively and consistently associated
with apo A-II regardless of alcohol consumption. Factor analysis revealed that serum selenium had no association with factors
that represented each lipoprotein fraction (LDL, HDL, and VLDL). The present study indicates that serum selenium is positively
correlated only with apo A-II levels. 相似文献
20.
The response of trout and zebrafish embryos to low and high boron concentrations is U-shaped 总被引:2,自引:0,他引:2
Fish in the embryo-larval stage of development have been shown to be sensitive to boron (B) at both ends of the dose-response
curve (1,2). The present study evaluated the health effects of low and high B concentrations on rainbow trout (Oncorhynchus mykiss), a cold water species, and zebrafish (Danio rerio), a warm water species. Rainbow trout embryos were incubated from day 1 until 2 wk posthatch in Type 1 ASTM ultrapure-grade
water (12.5°C) supplemented with only B (0-500 μM) as boric acid, or together with CaCO3 (0–2 mM) to increase water hardness. Embryonic growth was stimulated by B in a dose-dependent manner at all Ca concentrations
(p < 0.001). Chronic exposures below 9 μmol B/L impaired embryonic growth and above 10 mmol B/L caused death (p < 0.001). Thus, the safe range of exposure for the rainbow trout was between the adverse effect concentrations of 9 μmol
B/L and 10 mmol B/L. Zebrafish were maintained for 6 mo in ultrapure water containing <0.2 μmol B/L to determine the effect
of low-level exposure. High-level exposure was assessed by exposing zygotes, derived from parents maintained at 46 μmol B/L,
to graded concentrations of boric acid up to a concentration of 75 mmol B/L from fertilization until they were free feeding
(96 h). Fertilization occurred, but zygotes failed to survive when water contained <0.2 umol B/L (p < 0.001). Death occurred at and above 9.2 mmol B/L. Thus, the safe range of B exposure for zebrafish was between the adverse
effect concentrations of 0.2 μmol B/L and 9.2 mmol B/L. The dose-response for both species was thus U-shaped.
Part of this work was previously published in abstract form and presented at Experimental Biology 97, April 6–9, New Orleans,
LA (Eckhert, C. [1997] Embryonic trout growth and boron exposure,FASEB J.
11, A406 [abstract]). 相似文献