Decoding m6A RNA methylome identifies PRMT6-regulated lipid transport promoting AML stem cell maintenance

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PRMT6 methylation of RCC1 regulates mitosis,tumorigenicity, and radiation response of glioblastoma stem cells

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Molecular basis for substrate recruitment to the PRMT5 methylosome

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Spermine is a natural suppressor of AR signaling in castration-resistant prostate cancer

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CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth

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FACS-based genome-wide CRISPR screens define key regulators of DNA damage signaling pathways

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Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling

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Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses

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PRMT1 Is Recruited via DNA-PK to Chromatin Where It Sustains the Senescence-Associated Secretory Phenotype in Response to Cisplatin

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Arginine monomethylation by PRMT7 controls MAVS-mediated antiviral innate immunity

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Bistable,Biphasic Regulation of PP2A-B55 Accounts for the Dynamics of Mitotic Substrate Phosphorylation

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TOX4, an insulin receptor-independent regulator of hepatic glucose production,is activated in diabetic liver

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Chromatin-bound RB targets promoters,enhancers, and CTCF-bound loci and is redistributed by cell-cycle progression

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TNIP1 inhibits selective autophagy via bipartite interaction with LC3/GABARAP and TAX1BP1

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Nesprin-2 Recruitment of BicD2 to the Nuclear Envelope Controls Dynein/Kinesin-Mediated Neuronal Migration In Vivo

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1-deoxysphingolipids bind to COUP-TF to modulate lymphatic and cardiac cell development

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D1 and D2 neurons in the nucleus accumbens enable positive and negative control over sugar intake in mice

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Cryo-EM structure of CtBP2 confirms tetrameric architecture

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WWC proteins mediate LATS1/2 activation by Hippo kinases and imply a tumor suppression strategy

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Histone H2AK119 Mono-Ubiquitination Is Essential for Polycomb-Mediated Transcriptional Repression

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