High-Throughput Drug Screening Identifies a Potent Wnt Inhibitor that Promotes Airway Basal Stem Cell Homeostasis

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XFEL and NMR Structures of Francisella Lipoprotein Reveal Conformational Space of Drug Target against Tularemia

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Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers

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Orientation Preference Maps in Microcebus murinus Reveal Size-Invariant Design Principles in Primate Visual Cortex

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IPRO+/−: Computational Protein Design Tool Allowing for Insertions and Deletions

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Design and engineering of genetically encoded protein biosensors for small molecules

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Structural Insights into Rational Design of Single-Domain Antibody-Based Antitoxins against Botulinum Neurotoxins

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Design and application of oncolytic viruses for cancer immunotherapy

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Design,construction, and in vivo augmentation of a complex gut microbiome

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Design and engineering of artificial microbial consortia for biohydrogen production

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Longitudinal Human Antibody Repertoire against Complete Viral Proteome from Ebola Virus Survivor Reveals Protective Sites for Vaccine Design

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Design and fabrication of field-deployable microbial biosensing devices

Microbial biosensing devices contain whole-cell or cell-free biosensors as core elements. They offer advantages such as sensitive detection, a wide dynamic range, and cost-effective manufacturing.

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From structure to clinic: Design of a muscarinic M1 receptor agonist with the potential to treat Alzheimer’s disease

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Phosphotyrosine-based Phosphoproteomics for Target Identification and Drug Response Prediction in AML Cell Lines

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Highlights

• •pY phosphoproteomes and dedicated ranking analyses for 16 AML cell lines.
• •RTK drivers, 6 mutant cell lines confirmed, identification for 4 more cell lines.
• •MAPK1/3 phosphorylation for cell lines without TK driver, indicating RAS mutation.
• •Drug target space phosphorylation correlates with drug IC50s in specific cell lines.

     

The Circadian Clock Gene Circuit Controls Protein and Phosphoprotein Rhythms in Arabidopsis thaliana

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Parinarioidins A-B,unprecedented flavonoids from the bark of Brosimum parinarioides Ducke

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Predicting Successful Generation and Inhibition of Seizure-like Afterdischarges and Mapping Their Seizure Networks Using fMRI

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Opto-katanin,an optogenetic tool for localized,microtubule disassembly

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Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases

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Large-scale genome sequencing reveals the driving forces of viruses in microalgal evolution

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