Strand-specific ChIP-seq at DNA breaks distinguishes ssDNA versus dsDNA binding and refutes single-stranded nucleosomes

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A DddA ortholog-based and transactivator-assisted nuclear and mitochondrial cytosine base editors with expanded target compatibility

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Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice

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Structural insights into DarT toxin neutralization by cognate DarG antitoxin: ssDNA mimicry by DarG C-terminal domain keeps the DarT toxin inhibited

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Cryo-EM structures and biochemical insights into heterotrimeric PCNA regulation of DNA ligase

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Distribution and phasing of sequence motifs that facilitate CRISPR adaptation

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Cryo-EM structure of the Mre11-Rad50-Nbs1 complex reveals the molecular mechanism of scaffolding functions

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Persistence of RNA transcription during DNA replication delays duplication of transcription start sites until G2/M

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Genome-scale mapping of DNA damage suppressors through phenotypic CRISPR-Cas9 screens

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Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State

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Unique Structural Features of Mammalian NEIL2 DNA Glycosylase Prime Its Activity for Diverse DNA Substrates and Environments

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CENP-B-mediated DNA loops regulate activity and stability of human centromeres

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Sequence and chromatin features guide DNA double-strand break resection initiation

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RADX controls RAD51 filament dynamics to regulate replication fork stability

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Poly-ADP-ribosylation drives loss of protein homeostasis in ATM and Mre11 deficiency

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A replication fork determinant for the establishment of sister chromatid cohesion

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Chimeric CRISPR-CasX enzymes and guide RNAs for improved genome editing activity

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Sen1 Is Recruited to Replication Forks via Ctf4 and Mrc1 and Promotes Genome Stability

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A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization

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Structural mechanism of endonucleolytic processing of blocked DNA ends and hairpins by Mre11-Rad50

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