NAD+ boosting reduces age-associated amyloidosis and restores mitochondrial homeostasis in muscle

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NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency

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NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism

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The probiotic L. casei Zhang slows the progression of acute and chronic kidney disease

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Increased post-mitotic senescence in aged human neurons is a pathological feature of Alzheimer’s disease

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NAD precursors cycle between host tissues and the gut microbiome

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Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging

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Premature aging and reduced cancer incidence associated with near-complete body-wide Myc inactivation

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Resurrection of endogenous retroviruses during aging reinforces senescence

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A hyper-quiescent chromatin state formed during aging is reversed by regeneration

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Cell-cell metabolite exchange creates a pro-survival metabolic environment that extends lifespan

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Age-dependent instability of mature neuronal fate in induced neurons from Alzheimer’s patients

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Dynamic chromatin accessibility tuning by the long noncoding RNA ELDR accelerates chondrocyte senescence and osteoarthritis

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Amino acid catabolism regulates hematopoietic stem cell proteostasis via a GCN2-eIF2α axis

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The CD38/NAD/SIRTUIN1/EZH2 Axis Mitigates Cytotoxic CD8 T Cell Function and Identifies Patients with SLE Prone to Infections

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Restoration of CPEB4 prevents muscle stem cell senescence during aging

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The NADPARK study: A randomized phase I trial of nicotinamide riboside supplementation in Parkinson’s disease

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Individual cell types in C. elegans age differently and activate distinct cell-protective responses

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Bacteria Boost Mammalian Host NAD Metabolism by Engaging the Deamidated Biosynthesis Pathway

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A Single-Cell Transcriptomic Atlas of Human Skin Aging

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