DNA ADP-Ribosylation Stalls Replication and Is Reversed by RecF-Mediated Homologous Recombination and Nucleotide Excision Repair

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Upregulation of Antioxidant Capacity and Nucleotide Precursor Availability Suffices for Oncogenic Transformation

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A mechanism for SARS-CoV-2 RNA capping and its inhibition by nucleotide analog inhibitors

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Nucleotide Binding,Evolutionary Insights,and Interaction Partners of the Pseudokinase Unc-51-like Kinase 4

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NNT mediates redox-dependent pigmentation via a UVB- and MITF-independent mechanism

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Germline thymidylate synthase deficiency impacts nucleotide metabolism and causes dyskeratosis congenita

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Allosteric modulation of ryanodine receptor RyR1 by nucleotide derivatives

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A purine metabolic checkpoint that prevents autoimmunity and autoinflammation

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Structural Effects and Functional Implications of Phalloidin and Jasplakinolide Binding to Actin Filaments

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Stoichiometry of Nucleotide Binding to Proteasome AAA+ ATPase Hexamer Established by Native Mass Spectrometry

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Highlights

• •All six binding sites in PAN^WT are occupied by ADP- or ATP-type nucleotides.
• •PAN^KA Walker A mutant substoichiometrically binds ATP- but not ADP-type nucleotides.
• •PAN hexamer dissociation of the solution origin characteristics was observed in MS.
• •We posit that the PAN hexamer dissociation proceeds within the ESI droplets.

     

Structural basis for VIPP1 oligomerization and maintenance of thylakoid membrane integrity

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The CTPase activity of ParB determines the size and dynamics of prokaryotic DNA partition complexes

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Modulation of host glutamine anabolism enhances the sensitivity of small cell lung cancer to chemotherapy

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Innate immune response orchestrates phosphoribosyl pyrophosphate synthetases to support DNA repair

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Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2

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Deamidation Shunts RelA from Mediating Inflammation to Aerobic Glycolysis

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Molecular Mechanism Underlying Inhibition of Intrinsic ATPase Activity in a Ski2-like RNA Helicase

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Active DNA damage eviction by HLTF stimulates nucleotide excision repair

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Southern Hemisphere coasts are biologically connected by frequent,long-distance rafting events

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Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms

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