Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells

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The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function

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Mitochondrial Oxidative Phosphorylation Regulates the Fate Decision between Pathogenic Th17 and Regulatory T Cells

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Human gut microbiota stimulate defined innate immune responses that vary from phylum to strain

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CD4+ T cells regulate sickness-induced anorexia and fat wasting during a chronic parasitic infection

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Interleukin-23 receptor signaling impairs the stability and function of colonic regulatory T cells

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A unified atlas of CD8 T cell dysfunctional states in cancer and infection

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XCR1+ DCs are critical for T cell-mediated immunotherapy of chronic viral infections

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Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop

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The splicing isoform Foxp3Δ2 differentially regulates tTreg and pTreg homeostasis

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Membrane contact site-dependent cholesterol transport regulates Na+/K+-ATPase polarization and spermiogenesis in Caenorhabditis elegans

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Antigen presentation between T cells drives Th17 polarization under conditions of limiting antigen

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Graded BMP signaling within intestinal crypt architecture directs self-organization of the Wnt-secreting stem cell niche

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Mitochondrial Integrity Regulated by Lipid Metabolism Is a Cell-Intrinsic Checkpoint for Treg Suppressive Function

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Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity

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Mechanism of inert inflammation in an immune checkpoint blockade-resistant tumor subtype bearing transcription elongation defects

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Catalytic cycling of human mitochondrial Lon protease

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Lon degrades stable substrates slowly but with enhanced processivity,redefining the attributes of a successful AAA+ protease

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Glutathione Restricts Serine Metabolism to Preserve Regulatory T Cell Function

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Microbial exposure during early human development primes fetal immune cells

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