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1.
Moriwake Y Tohno Y Tohno S Azuma C Minami T Takano Y 《Biological trace element research》2002,88(3):215-222
To elucidate compositional changes of elements in the meniscus with aging, the authors investigated the relationships among
elements in the medial meniscus by inductively coupled plasma-atomic emission spectrometry. The subjects consisted of 16 men
and 7 women, ranging in age from 65 to 93 yr. In the left medial meniscus, extremely significant correlations were found both
between calcium and phosphorus contents and between sulfur and magnesium contents, whereas significant correlations were found
between calcium and either iron or zinc contents, between phosphorus and either iron or zinc contents, and between iron and
zinc contents. On the other hand, in the right medial meniscus, there were only an extremely significant correlation between
calcium and phosphorus contents and a significant correlation between sulfur and magnesium contents. The common finding between
the left and right medial menisci was an extremely significant correlation between calcium and phosphorus contents and a significant
correlation between sulfur and magnesium contents. 相似文献
2.
Setsuko Tohno Yumi Moriwake Yoshiyuki Tohno Takeshi Minami Fumio Nishiwaki Masako Utsumi Masa-oki Yamada 《Biological trace element research》1999,70(2):137-147
To examine age-related changes of human cardiac valves, mitral and tricuspid valves were analyzed by inductively coupled plasma-atomic
emission spectrometry. The subjects for mitral valves consisted of 12 men and 8 women, ranging in age from 52 to 96 yr. The
subjects for tricuspid valves consisted of 11 men and 6 women, ranging in age from 52 to 93 yr. Furthermore, 16 of the samples
of the cardiac valves were derived from the same subjects.
The contents of calcium, phosphorus, and magnesium in the mitral valves increased progressively with advancing age and reached
maximum in the 80s in regard to calcium and phosphorus and maximum in the 90s in regard to magnesium. The maximum average
amounts corresponded to about three times the average contents in the 60s. In contrast, the content of sulfur in the mitral
valves remained constant between the 50s and 90s.
Regarding tricuspid valve, the contents of calcium, phosphorus, and magnesium scarcely increased with advancing age, except
for one subject who died of chronic renal failure.
Histological observations of the mitral valves revealed that deposits of calcium were present in both the elastic fibers and
its degenerative tissues of the mitral valve.
The present study indicates that the accumulation of calcium, phosphorus, and magnesium occurs progressively in the mitral
valve with aging, but does not occur in the tricuspid valve. 相似文献
3.
Age-related changes of elements in the human articular disk of the temporomandibular joint 总被引:2,自引:0,他引:2
Takano Y Moriwake Y Tohno Y Minami T Tohno S Utsumi M Yamada M Okazaki Y Yamamoto K 《Biological trace element research》1999,67(3):269-276
To elucidate compositional changes of the articular disk (AD) of the temporomandibular joint (TMJ) by aging, elements of the
ADs resected from 18 cadavers were determined by inductively coupled plasma atomic-emission spectrometry. It was found that
calcium contents of ADs in TMJs increased progressively with aging, whereas the sulfur contents of the ADs decreased slightly
with aging. Regarding the content of phosphorus, the contents increased progressively with aging. The study revealed that
age-related changes of calcium contents in the ADs of TMJs were similar to those in women’s pubic symphyses, but not those
in intervertebral disks and menisci. 相似文献
4.
Takano Y Tohno Y Moriwake Y Tohno S Minami T Yamada MO Yuri K 《Biological trace element research》2000,74(2):117-125
To elucidate changes of the ureter with aging, the authors investigated age-related changes of element contents in human ureters.
The subjects consisted of seven men and seven women, ranging in age from 61 to 97 yr. The contents of calcium, sulfur, and
iron in the ureters increased progressively with aging, whereas the contents of phosphorus and magnesium did not increase
with aging. Significant relationships were found both between calcium and sulfur contents and between calcium and iron contents
in the ureters, but not between calcium and either phosphorus or magnesium contents. It was noteworthy that a significant
relationship was also found between sulfur and iron contents in the ureters. It remains uncertain whether calcium forms a
compound with sulfur or iron in aged human ureters or not. 相似文献
5.
Yamada M Tohno Y Takakura Y Tohno S Moriwake Y Minami T 《Biological trace element research》2003,91(1):57-66
To elucidate compositional changes of the tendons with aging, the authors investigated age-related changes of element contents
in the tendon of the iliopsoas muscle by inductively coupled plasma-atomic emission spectrometry. The subjects consisted of
14 men and 14 women, ranging in age from 4 to 102 yr. The insertion tendons of the iliopsoas were removed from the cadavers
after ordinary dissection and also surgically from patients with congenital dislocation of the hip. It was found that both
Mg and P in the tendon of the iliopsoas muscle increased significantly with aging, but the other elements, such as S, Ca,
Na, Zn, Fe, and Si, hardly changed with aging.
With regard to the relationship among element contents, extremely significant correlations were found between P and S contents,
between Mg and Na contents, and between S and Zn contents. In addition, very significant correlations were found between Si
and either S or Zn contents. However, there was no significant correlation between Ca and P contents. These results revealed
that with regard to age-related changes of element contents and the relationships among element contents, the tendon of the
iliopsoas muscle was different from the Achilles tendon, in which both Mg and P decreased significantly with aging and there
were significant correlations each other among the contents of S, Mg, and P. 相似文献
6.
Tohno S Takano Y Tohno Y Moriwake Y Minami T Utsumi M Yamada MO Yuri K 《Biological trace element research》2000,77(2):131-138
To elucidate compositional changes of human trachea by aging, element contents in tracheae were determined by inductively
coupled plasma-atomic emission spectrometry. The subjects consisted of seven men and seven women, ranging in age from 61 to
97 yr. The sulfur content of the tracheae decreased gradually with aging. In regard to calcium and phosphorus, both the contents
increased to about three-fold amounts in their seventies compared with those in their sixties, and decreased thereafter. The
contents of calcium and phosphorus were the highest in their seventies. Therefore, it is likely that surplus calcium released
from bones is deposited temporally in the trachea, and the deposits are released from the trachea at older age. Based on our
results of human cartilages, there are two types in regard to calcium accumulation: The first type is that calcium accumulation
occurs progressively with aging; the second one is that calcium accumulation becomes the highest in the seventies or eighties,
and decreases there-after. Therefore, the trachea belongs to the second type. Furthermore, the magnesium content remained
constant through the age range. 相似文献
7.
Yoshiytiki Tohno Setsuko Tohno Takeshi Minami Masako Utsumi Yumi Moriwake Fumio Nishiwaki Masa-oki Yamada Keizo Yamamoto Yasuo Takano Yuko Okazaki Hiroshi Yamamoto 《Biological trace element research》1998,61(2):219-226
To elucidate accumulations of minerals in the human aorta and internal thoracic artery, their relative contents (RCs) of minerals
were analyzed by inductively coupled plasma atomic emission spectrometry.
Aortas from 47 men and 24 women subjects were examined. The ages of these subjects ranged from newborn to 99 yr. After the
age of 40 yr, RCs of calcium and phosphorus began to increase, and thereafter increased stepwise in the 50s and 70s. In the
70s, their accumulations were markedly increased.
Internal thoracic arteries from 16 men and 7 women subjects were examined. These subjects ranged in age from 65–93 yr. It
was found that all the RCs of calcium were low, <5.0 mg/g dry wt, and there was no age-dependent increase of calcium contents
in internal thoracic arteries. 相似文献
8.
Age-related changes of elements and relationships among elements in human tendons and ligaments 总被引:1,自引:0,他引:1
Yamada M Tohno Y Tohno S Moriwake Y Azuma C Utsumi M Minami T Takano Y Takakura Y 《Biological trace element research》2004,98(2):129-142
To elucidate compositional changes of the tendons and ligaments with aging, the authors investigated age-related changes of
element contents in the insertion tendons of the biceps brachii muscle, central tendons of the diaphragma, Achilles’ tendons,
posterior longitudinal ligaments (PLLs) of the cervical spine, ligamenta capitum femorum, and anterior cruciate ligaments.
After ordinary dissections by medical students, the three tendons and three ligaments were resected and element contents were
determined by inductively coupled plasma-atomic emission spectrometry. It was found that the elements, such as Ca, P, S, Mg,
Na, Zn, and Fe, did not change significantly in the three tendons and two ligaments with aging, except for the PLLs where
Ca and Mg increased significantly with aging and Fe decreased significantly with aging.
With regard to the relationships among elements, the common finding that there were significant correlations between Ca and
P contents and between Ca and Mg contents was obtained in the three ligaments. Likewise, the common finding that there was
a significant correlation between Ca and Mg contents was obtained in the three tendons. Regarding the relationship between
Ca and P contents, the three tendons were different from the three ligaments. 相似文献
9.
Age-related changes of elements in human anterior cruciate ligaments and ligamenta capitum femorum 总被引:1,自引:0,他引:1
Yoshiyuki Tohno Yumi Moriwake Yasuo Takano Takeshi Minami Setsuko Tohno Masako Utsumi Masa-oki Yamada Keizo Yamamoto Yuko Okazaki Yoshinori Takakura 《Biological trace element research》1999,68(2):181-192
To elucidate compositional changes of human ligaments by aging, the content of elements in anterior cruciate ligaments (ACLs)
and ligamenta capitum femorum (LCFs) was analyzed by inductively coupled plasma-atomic emission spectrometry. The subjects
consisted of 11 men and 7 women, ranging from 59 to 91 yr of age. With regard to the content of elements, the content of sulfur
and iron was significantly higher in the LCFs than in the ACLs. It was found in the ACLs that the content of sulfur decreased
gradually with aging, whereas the content of calcium, phosphorus, and magnesium increased progressively with aging. On the
other hand, it was found in the LCFs that the content of magnesium decreased gradually with aging, whereas the content of
phosphorus increased progressively with aging. The common finding that the content of phosphorus increased with aging, but
the content of iron decreased, was obtained in the ACL and LCF. Regarding sexual difference, it was found in both the ACLs
and LCFs that the content of phosphorus was higher in women’s ligaments than in men’s. 相似文献
10.
Tohno Y Tohno S Azuma C Moriwake Y Naganuma T Ohnishi Y Minami T 《Biological trace element research》2003,96(1-3):93-107
To elucidate compositional changes of the thoracic duct with aging, the authors investigated age-related changes of elements
in the thoracic ducts in comparison with the azygos veins. The subjects consisted of 22 men and 1 woman, ranging in age from
65 to 95 yr. After ordinary dissection, the thoracic ducts and azygos veins were resected from the subjects and element contents
were determined by inductively coupled plasma-atomic emission spectrometry. It was found that calcium appeared to increase
in the thoracic duct with aging, but the other elements, such as phosphorus, sulfur, magnesium, iron, zinc, and sodium, did
not change significantly with aging. In the azygos vein, both calcium and sulfur increased significantly with aging.
Regarding the relationship among elements, extremely significant direct correlations were found among calcium, phosphorus,
sulfur, and magnesium in the thoracic ducts, except for phosphorus and magnesium contents with a very significant direct correlation.
In the azygos veins, significant direct correlations were found between calcium and sulfur contents and between sulfur and
magnesium contents. However, no significant correlations were found among calcium, phosphorus, and magnesium in the azygos
veins. These results revealed that with regard to the relationship among calcium, phosphorus, and magnesium, the thoracic
duct was similar to the arteries, but not to the azygos vein. 相似文献
11.
Tohno S Tohno Y Minami T Moriwake Y Azuma C Ohnishi Y 《Biological trace element research》2002,88(3):223-233
To elucidate compositional changes of the veins with aging, the authors investigated the relationships among element contents
in the internal jugular veins, in which a higher accumulation of calcium and phosphorus occurred with aging. The subjects
consisted of 15 men and 10 women, ranging in age from 40 to 98 yr. The element contents of the internal jugular veins were
determined by inductively coupled plasma-atomic emission spectrometry. It was found that there were extremely significant
direct correlations among the contents of calcium, phosphorus, magnesium, and sodium in the internal jugular vein. In addition,
very significant direct correlations were also found both between zinc and either iron or silicon contents and between sulfur
and iron contents in the vein. As calcium and phosphorus increased in the internal jugular vein, the mass ratios of Mg/Ca
and Mg/P decreased gradually in the vein, whereas the mass ratio of Ca/P hardly decreased. These results indicated that with
regard to both the relationships among the contents of calcium, phosphorus, and magnesium and the changes of the mass ratios
of Mg/Ca and Mg/P, the internal jugular vein was very similar to the arteries. 相似文献
12.
Habata T Ohgushi H Takakura Y Tohno Y Moriwake Y Minami T Fujisawa Y 《Biological trace element research》2001,79(3):247-256
The purpose of this study is to investigate the relationship between meniscal degeneration and element contents. The contents
of elements (calcium, phosphorus, sulfur, and magnesium) in the menisci from 17 patients with osteoarthritis (OA) of the knee,
6 with rheumatoid arthritis (RA), and 2 who underwent the surgical operation for malignant tumors (control) were analyzed
by inductively coupled plasma-atomic emission spectrometry, and the menisci were divided into four stages (Stage 0–3) of histological
degeneration.
The calcium contents of the menisci were 0.26±0.16 in Stage 0, 0.50±0.37 in Stage 1, and 0.69±0.66 in Stage 2, respectively
(the values represent mg elements/g dry tissue). They increased with the progression of the stage. This tendency was found
in the menisci with OA, but was not clear in those with RA. The calcium content in the control group was 0.17±0.09 mg/g. There
was no significant relationship between the stage of degeneration and the contents of phosphorus, sulfur, or magnesium. The
calcium content of the meniscus might indicate the degree of meniscal degeneration. 相似文献
13.
Yumi Moriwake Yoshiyuki Tohno Setsuko Tohno Cho Azuma Takeshi Minami 《Biological trace element research》2001,83(2):121-132
To examine an accumulation of elements within the arteries with aging, the authors investigated the element contents in the
intimal, middle, and external tunicae of the thoracic aorta. The subjects consisted of six men and four women, ranging in
age from 57 to 99 yr. The wall of the thoracic aorta was separated into the intimal, middle, and external tunicae by scrubbing
the wall of the thoracic aorta with an edge of slide glass and the element contents were determined by inductively coupled
plasma-atomic emission spectrometry. It was found that there were significant relationships among calcium, phosphorus, magnesium,
sulfur, and sodium in both the intimal and middle tunicae of the aorta, but not in the external tunica. These results revealed
that no significant differences were found in element compositions of deposits between the intimal and middle tunicae. 相似文献
14.
Mahakkanukrauh P Tohno S Tohno Y Azuma C Ongkana N Moriwake Y Minami T 《Biological trace element research》2005,106(3):219-229
To examine whether there were differences between reces in regard to age-related changes of elements and the relationships
among elements in the arteries, the authors investigated both the renal arteries of Thai and Japanese. The Thai subjects consisted
of 27 men and 11 women, ranging in age from 27 to 88 yr, whereas the Japanese subjects consisted of 19 men and 26 women, ranging
in age from 61 to 99 yr. After the ordinary dissections at Chiang Mai University and Nara Medical University were completed,
the bilateral renal arteries were resected and the element contents were determined by inductively coupled plasma-atomic emission
spectrometry. In the Thai, a slight accumulation of calcium and phosphorus occurred in the fifties, but thereafter headly
increased. In contrast, in the Japanese, an accumulation of calcium and phosphorus began to occur in the seventies and increased
markedly in the eighties. The result reveraled that a higher accumulation of calcium and phosphorus occurred in the renal
arteries of the Japanese in old age compared with those of the Thai. Regarding the relationships among elements, extremely
or very significant direct correlations were found among the contents of calcium, phosphorus, magnesium, and sodium in both
the renal arteries of the Thai and Japanese, except for magnesium and sodium contents in the renal arteries of the Thai. 相似文献
15.
Age-related changes of elements and relationships among elements in the common bile and pancreatic ducts 总被引:1,自引:0,他引:1
Tohno Y Tohno S Yamada MO Azuma C Moriwake Y Minami T Maruyama H Omura T 《Biological trace element research》2004,101(1):47-60
To elucidate compositional changes of the common bile and main pancreatic ducts with aging, the authors investigated age-related
changes of element contents in the common bile and pancreatic ducts by inductively coupled plasma-atomic emission spectrometry.
After ordinary dissection by medical students was finished, the common bile ducts and main pancreatic ducts (pancreatic ducts)
were resected and the element contents were determined. The Mg content increased significantly only in the pancreatic duct
with aging, but the other element contents did not change significantly in both the common bile and pancreatic ducts with
aging. Regarding the relationship among the elements, significant direct correlations were found among the contents of Ca,
P, S, and Mg in the common bile ducts, with some exceptions between P and either S or Mg contents. In the pancreatic ducts,
significant direct correlations were found between S and Mg contents and between P and Na contents. The relationships in the
elements between the common bile and pancreatic ducts were examined. It was found that there were significant direct correlations
in the Ca, Mg, and Fe contents between the common bile and pancreatic ducts; that is, as Ca, Mg, and Fe increased in the common
bile duct, they increased simultaneously in the pancreatic duct. 相似文献
16.
Tohno Y Takano Y Tohno S Moriwake Y Minami T Nishiwaki F Yamada MO Utsumi M Yuri K 《Biological trace element research》2000,77(2):119-129
To elucidate changes of peripheral nerves with aging, the authors studied age-related changes of element contents in the optic,
radial, and sciatic nerves by inductively coupled plasma-atomic emission spectrometry. The subjects consisted of seven men
and seven women, ranging in age from 61 to 97 yr. The contents of phosphorus and sulfur remained constant through ages 61
to 97 yr in three nerves, the optic, radial, and sciatic nerves. It was found that there were age-related differences in calcium
content among the optic, radial, and sciatic nerves: The calcium content of the optic nerve increased progressively with aging;
in the radial nerve, it was hardly changed with aging; in contrast, the calcium content of the sciatic nerve decreased gradually
with aging. In addition, it was found that in the radial nerve there were moderate correlations between age and zinc or sodium
content, whereas significant correlations between age and the content of silicon or iron were found in the sciatic nerve.
Furthermore, there was a correlation between the silicon and iron contents in the sciatic nerves. 相似文献
17.
Naganuma T Naruse K Tohno Y Tohno S Yamasaki M Minami T Moriwake Y Morikawa H 《Biological trace element research》2004,102(1-3):73-82
To elucidate the compositional change of ligaments with aging, the authors investigated both age-related changes of elements
and relationships among elements in the round ligaments of the uterus (round ligaments) by inductively coupled plasma-atomic
emission spectrometry. The bilateral round ligaments were resected from 20 cadavers and also from the uteri removed surgically
from 11 patients bearing uterine myoma or cancer. Thirty-one subjects ranged in age from 34 to 92 yr. It was found that both
S and Mg decreased gradually in the round ligaments with aging, but Ca, P, Zn, Fe, and Al did not change significantly with
aging. Regarding the relationships among elements, very significant direct correlations were found among the contents of Ca,
P, S, and Mg in the round ligaments, whereas significant inverse correlations were found between the contents of Zn and elements,
such as Ca, P, S, and Mg. It should be noted that there was an extremely significant direct correlation between Ca and P contents
in the round ligaments. 相似文献
18.
Utsumi M Tohno S Tohno Y Azuma C Moriwake Y Nishiwaki F Yamada MO Minami T 《Biological trace element research》2004,98(3):229-252
To elucidate compositional changes of peripheral nerves with aging, the authors investigated age-related changes of elements
and their relationships in the optic, trigeminal, vagus, median, radial, ulnar, femoral, sciatic, tibial, and common peroneal
nerves by inductively coupled plasma-atomic emission spectrometry. The subjects consisted of 10 men and 12 women, ranging
in age from 65 to 91 yr. It was found that although accumulations of Ca and P occurred only in the trigeminal nerve at old
age, it hardly occurred in the optic, vagus, median, radial, ulnar, femoral, sciatic, tibial, and common peroneal nerves at
old age. The average contents of Ca and P were three and two times higher in the trigeminal nerve than in the other nine kinds
of nerve, respectively. Likewise, the average content of Mg was a little higher in the trigeminal nerve compared with the
other nerves.
With regard to the relationships among elements, significant direct correlations were found among the contents of Ca, P, S,
and Mg in most, but not all, 10 kinds of nerve. In the trigeminal nerve, a significant inverse correlation was found between
the contents of S and the other elements, such as Ca, P, and Mg. Regarding the relationships between the contents of S and
other elements, the nerves, except for the trigeminal nerve, differed from those found in the arteries previously reported. 相似文献
19.
Setsuko Tohno Yoshiyuki Tohno Takeshi Minami Masayo Ichii Yuko Okazaki Masako Utsumi Fumio Nishiwaki Masa-oki Yamada 《Biological trace element research》1996,52(2):117-124
To establish a difference of the relative contents (RCs) of elements among the cervical, thoracic, and lumbar intervertebral
disks and its age-related change, the intervertebral disks between the axis and the sacrum, which were resected from the nine
cadavers who died at 53 to 99 yr old, were analyzed by inductively coupled atomic plasma emission spectrometry. It was found
that both the RCs of calcium and phosphorus were high in the cervical disks, especially the highest in the disk between the
6th and 7th cervical vertebrae, and lower in the order of the cervical, thoracic, and lumbar intervertebral disks. In regard
to the RCs of sulfur and magnesium, there were no significant differences among the cervical, thoracic, and lumbar intervertebral
disks. In addition, it was found that both the RCs of calcium and phosphorus in the cervical intervertebral disks started
to increase in the sixth decade of life, became the highest in the eighth decade of life, and then decreased. 相似文献
20.
Tohno Y Tohno S Satoh H Minami T Moriwake Y Azuma C Ohnishi Y 《Biological trace element research》2002,88(3):203-213
To elucidate compositional changes of the mitral valve with aging, the authors investigated the relationships among element
contents in the mitral valves. The subjects consisted of 10 men and 15 women, ranging in age from 65 to 102 yr. After the
ordinary dissection, mitral valves, lower parts of the interventricular septa, and terminal crests containing the sinoatrial
nodes were resected and the element contents were determined by inductively coupled plasma-atomic emission spectrometry. The
interventricular septa and sinoatrial nodes were used to compare with the mitral valves. With regard to the mitral valve,
it was found that extremely significant correlations were found among the contents of Ca, P, Mg, and Na, but no significant
correlations were found between the contents of S and elements such as Ca, P, or Mg. Regarding the interventricular septum,
it was found that an extremely significant correlation was found between P and S contents; very significant correlations were
found between Ca and Mg contents and between Mg and S contents; and a significant correlation was found between P and Mg contents.
However, no significant correlation was found between Ca and P contents in the interventricular septa. In the terminal crest
containing the sinoatrial node, significant correlations were found among the contents of Ca, P, Mg, and S. The present study
revealed that with regard to the relationships among element contents, the compositional change of the mitral valve was intermediate
between those of the thoracic aorta and the interventricular septum. 相似文献