共查询到20条相似文献,搜索用时 15 毫秒
1.
David C Muller Graham G Giles Julie Bassett Howard A Morris John T Manning John L Hopper Dallas R English Gianluca Severi 《Reproductive biology and endocrinology : RB&E》2011,9(1):57
Background
The second to fourth digit ratio (2D:4D) is used as a marker of prenatal sex hormone exposure. The objective of this study was to examine whether circulating concentrations of sex hormones and SHBG measured in adulthood was associated with 2D:4D. 相似文献2.
Background
Solving bioinformatics tasks often requires extensive computational power. Recent trends in processor architecture combine multiple cores into a single chip to improve overall performance. The Cell Broadband Engine (CBE), a heterogeneous multi-core processor, provides power-efficient and cost-effective high-performance computing. One application area is image analysis and visualisation, in particular registration of 2D cross-sections into 3D image datasets. Such techniques can be used to put different image modalities into spatial correspondence, for example, 2D images of histological cuts into morphological 3D frameworks. 相似文献3.
Saveria Aquila Carmela Guido Emilia Middea Ida Perrotta Rosalinda Bruno Michele Pellegrino Sebastiano Andò 《Reproductive biology and endocrinology : RB&E》2009,7(1):140-13
Background
A wider biological role of 1alpha,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the active metabolite of vitamin D3, in tissues not primarily related to mineral metabolism was suggested. Recently, we evidenced the ultrastructural localization the 1,25(OH)2D3 receptor in the human sperm. However, the 1,25(OH)2D3 action in human male reproduction has not yet been clarified. 相似文献4.
Benjamin Schmid Johannes Schindelin Albert Cardona Mark Longair Martin Heisenberg 《BMC bioinformatics》2010,11(1):274
Background
Current imaging methods such as Magnetic Resonance Imaging (MRI), Confocal microscopy, Electron Microscopy (EM) or Selective Plane Illumination Microscopy (SPIM) yield three-dimensional (3D) data sets in need of appropriate computational methods for their analysis. The reconstruction, segmentation and registration are best approached from the 3D representation of the data set. 相似文献5.
Rossini M Maddali Bongi S La Montagna G Minisola G Malavolta N Bernini L Cacace E Sinigaglia L Di Munno O Adami S 《Arthritis research & therapy》2010,12(6):R216
Introduction
The aim of this study was to estimate the prevalence and determinants of vitamin D deficiency in patients with rheumatoid arthritis (RA) as compared to healthy controls and to analyze the association between 25-hydroxyvitamin D (25(OH)D) with disease activity and disability. 相似文献6.
Sonia Do Carmo Jean-Claude Forest Yves Giguère André Masse Julie Lafond Eric Rassart 《Reproductive biology and endocrinology : RB&E》2009,7(1):92
Background
Apolipoprotein D (ApoD) is a lipocalin involved in several processes including lipid transport, but its modulation during human pregnancy was never examined. 相似文献7.
Georgios M Anifandis Konstantinos Dafopoulos Christina I Messini Nektarios Chalvatzas Nikolaos Liakos Spyros Pournaras Ioannis E Messinis 《Reproductive biology and endocrinology : RB&E》2010,8(1):91
Objectives
The aim of the present study was to measure serum and follicular fluid 25-OH vitamin D and glucose levels in women who underwent IVF-ET treatment and to further investigate whether the circulating 25-OH vitamin D and glucose levels correlate with IVF success. 相似文献8.
Background
The phospholipase D (PLD) family has been identified in plants by recent molecular studies, fostered by the emerging importance of plant PLDs in stress physiology and signal transduction. However, the presence of multiple isoforms limits the power of conventional biochemical and pharmacological approaches, and calls for a wider application of genetic methodology. 相似文献9.
Rebecca E Oberley Kelli L Goss Amado A Quintar Cristina A Maldonado Jeanne M Snyder 《Reproductive biology and endocrinology : RB&E》2007,5(1):42-9
Background
Surfactant protein D (SP-D) is an innate immune protein that is present in mucosal lined surfaces throughout the human body, including the male reproductive tract. In the present study, we characterized the regulation of SP-D expression in the mouse and rat prostate. 相似文献10.
Gang Li Tianming Liu Ashley Tarokh Jingxin Nie Lei Guo Andrew Mara Scott Holley Stephen TC Wong 《BMC cell biology》2007,8(1):40
Background
Reliable segmentation of cell nuclei from three dimensional (3D) microscopic images is an important task in many biological studies. We present a novel, fully automated method for the segmentation of cell nuclei from 3D microscopic images. It was designed specifically to segment nuclei in images where the nuclei are closely juxtaposed or touching each other. The segmentation approach has three stages: 1) a gradient diffusion procedure, 2) gradient flow tracking and grouping, and 3) local adaptive thresholding. 相似文献11.
David M Kristensen R Matthew Ward Andreas Martin Lisewski Serkan Erdin Brian Y Chen Viacheslav Y Fofanov Marek Kimmel Lydia E Kavraki Olivier Lichtarge 《BMC bioinformatics》2008,9(1):17
Background
Structural genomics projects such as the Protein Structure Initiative (PSI) yield many new structures, but often these have no known molecular functions. One approach to recover this information is to use 3D templates – structure-function motifs that consist of a few functionally critical amino acids and may suggest functional similarity when geometrically matched to other structures. Since experimentally determined functional sites are not common enough to define 3D templates on a large scale, this work tests a computational strategy to select relevant residues for 3D templates. 相似文献12.
Background
The protein folding problem is a fundamental problems in computational molecular biology and biochemical physics. Various optimisation methods have been applied to formulations of the ab-initio folding problem that are based on reduced models of protein structure, including Monte Carlo methods, Evolutionary Algorithms, Tabu Search and hybrid approaches. In our work, we have introduced an ant colony optimisation (ACO) algorithm to address the non-deterministic polynomial-time hard (NP-hard) combinatorial problem of predicting a protein's conformation from its amino acid sequence under a widely studied, conceptually simple model – the 2-dimensional (2D) and 3-dimensional (3D) hydrophobic-polar (HP) model. 相似文献13.
Background
Blood group genotyping is increasingly utilized for prenatal diagnosis and after recent transfusions, but still lacks the specificity of serology. In whites, the presence of antigen D is predicted, if two or more properly selected RHD-specific polymorphism are detected. This prediction must fail, if an antigen D negative RHD positive allele is encountered. Excluding RHDψ and Cde S frequent only in individuals of African descent, most of these alleles are unknown and the population frequency of any such allele has not been determined. 相似文献14.
April DeLaurier Nicholas Burton Michael Bennett Richard Baldock Duncan Davidson Timothy J Mohun Malcolm PO Logan 《BMC developmental biology》2008,8(1):83
Background
The developing mouse limb is widely used as a model system for studying tissue patterning. Despite this, few references are available that can be used for the correct identification of developing limb structures, such as muscles and tendons. Existing textual references consist of two-dimensional (2D) illustrations of the adult rat or mouse limb that can be difficult to apply when attempting to describe the complex three-dimensional (3D) relationship between tissues. 相似文献15.
Nicklas H Staunstrup Nynne Sharma Rasmus O Bak Lars Svensson Thomas K Petersen Lene Aarenstrup Karsten Kristiansen Lars Bolund Jacob Giehm Mikkelsen 《BMC biotechnology》2011,11(1):33
Background
Analogues of vitamin D3 are extensively used in the treatment of various illnesses, such as osteoporosis, inflammatory skin diseases, and cancer. Functional testing of new vitamin D3 analogues and formulations for improved systemic and topical administration is supported by sensitive screening methods that allow a comparative evaluation of drug properties. As a new tool in functional screening of vitamin D3 analogues, we describe a genomically integratable sensor for sensitive drug detection. This system facilitates assessment of the pharmacokinetic and pharmadynamic properties of vitamin D3 analogues. The tri-cistronic genetic sensor encodes a drug-sensoring protein, a reporter protein expressed from an activated sensor-responsive promoter, and a resistance marker. 相似文献16.
Background
Since many of the new protein structures delivered by high-throughput processes do not have any known function, there is a need for structure-based prediction of protein function. Protein 3D structures can be clustered according to their fold or secondary structures to produce classes of some functional significance. A recent alternative has been to detect specific 3D motifs which are often associated to active sites. Unfortunately, there are very few known 3D motifs, which are usually the result of a manual process, compared to the number of sequential motifs already known. In this paper, we report a method to automatically generate 3D motifs of protein structure binding sites based on consensus atom positions and evaluate it on a set of adenine based ligands. 相似文献17.
Emilie Millerot-Serrurot Marie Guilbert Nicolas Fourré Wojciech Witkowski Georges Said Laurence Van Gulick Christine Terryn Jean-Marie Zahm Roselyne Garnotel Pierre Jeannesson 《Cancer cell international》2010,10(1):26
Background
The cell microenvironment, especially extracellular matrix proteins, plays an important role in tumor cell response to chemotherapeutic drugs. The present study was designed to investigate whether this microenvironment can influence the antimigratory effect of an anthracycline drug, doxorubicin, when tumor cells are grown in a matrix of type I collagen, a three-dimensional (3D) context which simulates a natural microenvironment. 相似文献18.
Guangjie?Feng Nick?Burton Bill?Hill Duncan?Davidson Janet?Kerwin Mark?Scott Susan?Lindsay Richard?Baldock
Background
Many three-dimensional (3D) images are routinely collected in biomedical research and a number of digital atlases with associated anatomical and other information have been published. A number of tools are available for viewing this data ranging from commercial visualization packages to freely available, typically system architecture dependent, solutions. Here we discuss an atlas viewer implemented to run on any workstation using the architecture neutral Java programming language. 相似文献19.
Marie-Claude Dery Celine Van Themsche Diane Provencher Anne-Marie Mes-Masson Eric Asselin 《Reproductive biology and endocrinology : RB&E》2007,5(1):38-14
Background
To date, tools to study metastasis in endometrial cancers are insufficiently developed. The aim of this study was to characterize the cell line EN-1078D, a new endometrial carcinoma cell line derived from a metastasis to the ovary. 相似文献20.