共查询到5条相似文献,搜索用时 15 毫秒
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Chi‐Hang Lee William K.T. Hau Bee‐Choo Tai Mark Y. Chan Betty Saw Qian‐Hui Phua Adrian F. Low Tiong‐Cheng Yeo A. Mark Richards Huay‐Cheem Tan 《Obesity (Silver Spring, Md.)》2012,20(12):2451-2457
Despite potent insulin‐sensitizing, anti‐inflammatory, and antiatherogenic effects in animal studies, the relationship between serum adiponectin level and coronary artery disease in patients remains unclear. We determined the adiponectin profile in a cohort of multiethnic Asian patients with coronary artery disease, and the association between serum adiponectin level and culprit lesion necrotic core (NC) content. Ninety‐four Asian patients (BMI, 25.3 ± 3.7 kg/m2) undergoing percutaneous coronary intervention were recruited. The serum adiponectin level was measured (n = 94), and the baseline virtual histology intravascular ultrasound examination was analyzed (n = 88). The median level of adiponectin was 3.7 µg/ml (interquartile range, 2.8–4.5 µg/ml). The serum adiponectin level was below 10 µg/ml in 90 patients (95.7%) and below 6 µg/ml in 80 patients (85.1%). There was a significant association between ethnicity and serum adiponectin level (P = 0.048). The median adiponectin level was highest among the Chinese, followed by the Malay and the Indians. Serum adiponectin levels were positively associated with culprit lesion NC content. A 1‐µg/ml increase in log adiponectin was associated with a 3.04% (95% confidence interval: 0.33–5.44) increase in culprit lesion NC content. This association remains significant after adjusting for age, sex, ethnicity, low‐density lipoprotein cholesterol, high‐density lipoprotein cholesterol, and procedural indication. We found a low serum level of adiponectin in Asian patients and a significant ethnic effect on serum adiponectin level. Increased serum adiponectin levels were independently associated with increased culprit lesion NC burden, suggesting a role for adiponectin in modulating coronary plaque vulnerability. 相似文献
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You-Dong Wan Tong-Wen Sun Quan-Cheng Kan Fang-Xia Guan Zi-Qi Liu Shu-Guang Zhang 《PloS one》2016,11(1)
Background
Intra-aortic balloon pumps (IABP) have generally been used for patients undergoing high-risk mechanical coronary revascularization. However, there is still insufficient evidence to determine whether they can improve outcomes in reperfusion therapy patients, mainly by percutaneous coronary intervention (PCI) with stenting or coronary artery bypass graft (CABG). This study was designed to determine the difference between high-risk mechanical coronary revascularization with and without IABPs on mortality, by performing a meta-analysis on randomized controlled trials of the current era.Methods
Pubmed and Embase databases were searched from inception to May 2015. Unpublished data were obtained from the investigators. Randomized clinical trials of IABP and non-IABP in high-risk coronary revascularization procedures (PCI or CABG) were included. In the case of PCI procedures, stents should be used in more than 80% of patients. Numbers of events at the short-term and long-term follow-up were extracted.Results
A total of 12 randomized trials enrolling 2155 patients were included. IABPs did not significantly decrease short-term mortality (relative risk (RR) 0.66; 95% CI, 0.42–1.01), or long-term mortality (RR 0.79; 95% CI, 0.47–1.35), with low heterogeneity across the studies. The findings remained stable in patients with acute myocardial infarction with or without cardiogenic shock. But in high-risk CABG patients, IABP was associated with reduced mortality (71 events in 846 patients; RR 0.40; 95%CI 0.25–0.67).Conclusion
In patients undergoing high-risk coronary revascularization, IABP did not significantly decrease mortality. But high-risk CABG patients may be benefit from IABP. Rigorous criteria should be applied to the use of IABPs. 相似文献4.
Gabriele Giacomo Schiattarella Fabio Cattaneo Gianluigi Pironti Fabio Magliulo Giuseppe Carotenuto Marinella Pirozzi Roman Polishchuk Domenica Borzacchiello Roberta Paolillo Marco Oliveti Nicola Boccella Marisa Avvedimento Maria Sepe Giuseppe Gargiulo Assunta Lombardi Rosa Anna Busiello Bruno Trimarco Giovanni Esposito Antonio Feliciello Cinzia Perrino 《PloS one》2016,11(7)
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Ke Yang Lin Lu Yan Liu Qi Zhang Li Jin Pu Lin Jie Wang Zhen Bing Zhu Ya. Nan Wang Hua Meng Xiao Jie Zhang Run Du Qiu Jing Chen Wei Feng Shen 《PloS one》2013,8(12)