共查询到20条相似文献,搜索用时 31 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
FoxO3a and BCR-ABL regulate cyclin D2 transcription through a STAT5/BCL6-dependent mechanism 下载免费PDF全文
Fernández de Mattos S Essafi A Soeiro I Pietersen AM Birkenkamp KU Edwards CS Martino A Nelson BH Francis JM Jones MC Brosens JJ Coffer PJ Lam EW 《Molecular and cellular biology》2004,24(22):10058-10071
11.
A Philipp A Schneider I V?srik K Finke Y Xiong D Beach K Alitalo M Eilers 《Molecular and cellular biology》1994,14(6):4032-4043
12.
13.
14.
Estrogens and progesterone promote persistent CCND1 gene activation during G1 by inducing transcriptional derepression via c-Jun/c-Fos/estrogen receptor (progesterone receptor) complex assembly to a distal regulatory element and recruitment of cyclin D1 to its own gene promoter 下载免费PDF全文
Cicatiello L Addeo R Sasso A Altucci L Petrizzi VB Borgo R Cancemi M Caporali S Caristi S Scafoglio C Teti D Bresciani F Perillo B Weisz A 《Molecular and cellular biology》2004,24(16):7260-7274
15.
16.
STAT1 pathway is involved in activation of caprine arthritis-encephalitis virus long terminal repeat in monocytes. 下载免费PDF全文
The caprine arthritis-encephalitis virus (CAEV) long terminal repeat (LTR) is activated by gamma interferon (IFN-gamma) in promonocytic cells. We have previously shown that a 70-bp element is necessary and sufficient for the response of the CAEV LTR to this cytokine. At the 5' end, this 70-bp IFN-gamma response element contains sequence similarity to the gamma activated site (GAS). Here we demonstrate that the putative GAS element in the CAEV LTR binds specifically to a cellular factor induced by IFN-gamma in promonocytic cells. Substitution mutations in this consensus sequence eliminate binding of the inducible factor. The GAS element from the 70-bp motif is sufficient to confer responsiveness to IFN-gamma using a heterologous minimal promoter. Consistent with the binding data, the same mutations in the GAS element eliminate responsiveness to IFN-gamma in the context of both a functional CAEV LTR and a heterologous promoter. The cellular factor that binds to the GAS element is present from 5 min to 14 h after stimulation with IFN-gamma. Binding of the nuclear factor to the GAS element in the CAEV LTR is inhibited by antibody directed against STAT1 (p91/84). Thus, the GAS sequence in the CAEV LTR is essential for the response to IFN-gamma and a STAT1-like factor binds to this site. The STAT-1 signaling pathway provides at least one mechanism for activation of the CAEV LTR by IFN-gamma in monocytes. These data are the first demonstration of a role for a STAT family member in the regulation of a viral promoter. 相似文献
17.
18.
19.