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Shamsher MK Chuzhanova NA Friedman B Scopes DA Alhaq A Millar DS Cooper DN Berg LP 《Human genetics》2000,107(5):458-465
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The TAF subunits of TFIID mediate activation of subsets of the eukaryotic genome. Recent results demonstrate that TFIID is recruited to promoters in an activator-specific manner involving functional interaction between upstream regulatory elements and the core promoter, thereby coordinating the expression of distinct sets of genes. 相似文献
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A mammary cell-specific enhancer in mouse mammary tumor virus DNA is composed of multiple regulatory elements including binding sites for CTF/NFI and a novel transcription factor, mammary cell-activating factor. 总被引:7,自引:3,他引:4
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S Mink E H?rtig P Jennewein W Doppler A C Cato 《Molecular and cellular biology》1992,12(11):4906-4918
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Functional dissection of Escherichia coli promoters: information in the transcribed region is involved in late steps of the overall process. 总被引:29,自引:4,他引:25
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After binding to a promoter Escherichia coli RNA polymerase is in contact with a region of about 70 bp. Around 20 bp of this sequence are transcribed. Information encoded within this transcribed region is involved in late steps of the functional program of a promoter. By changing such 'down-stream' sequences promoter strength in vivo can be varied more than 10-fold. By contrast, information for early steps of the promoter program such as recognition by the enzyme and formation of a stable complex resides in a central core region of about 35 bp. Our data show that the strength of a promoter can be limited at different levels of the overall process. Consequently promoters of identical strength can exhibit different structures due to an alternate optimization of their program. 相似文献
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