共查询到20条相似文献,搜索用时 31 毫秒
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Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor 总被引:121,自引:0,他引:121
R Schüle P Rangarajan S Kliewer L J Ransone J Bolado N Yang I M Verma R M Evans 《Cell》1990,62(6):1217-1226
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E A Allegretto T Smeal P Angel B M Spiegelman M Karin 《Journal of cellular biochemistry》1990,42(4):193-206
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Repression of interleukin-5 transcription by the glucocorticoid receptor targets GATA3 signaling and involves histone deacetylase recruitment 总被引:4,自引:0,他引:4
Jee YK Gilmour J Kelly A Bowen H Richards D Soh C Smith P Hawrylowicz C Cousins D Lee T Lavender P 《The Journal of biological chemistry》2005,280(24):23243-23250
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DNA binding activities of three murine Jun proteins: stimulation by Fos 总被引:144,自引:0,他引:144
Three members of the Jun/AP-1 family have been identified in mouse cDNA libraries: c-Jun, Jun-B, and Jun-D. We have compared the DNA binding properties of the Jun proteins by using in vitro translation products in gel retardation assays. Each protein was able to bind to the consensus AP-1 site (TGACTCA) and, with lower affinity, to related sequences, including the cyclic AMP response element TGACGTCA. The relative binding to the oligonucleotides tested was similar for the different proteins. The Jun proteins formed homodimers and heterodimers with other members of the family, and they were bound to the AP-1 site as dimers. When Fos translation product was present, DNA binding by Jun increased markedly, and the DNA complex contained Fos. The C-terminal homology region of Jun was sufficient for DNA binding, dimer formation, and interaction with Fos. Our general conclusion is that c-Jun, Jun-B, and Jun-D are similar in their DNA binding properties and in their interaction with Fos. If there are functional differences between them, they are likely to involve other activities of the Jun proteins. 相似文献
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DeNardo DG Kim HT Hilsenbeck S Cuba V Tsimelzon A Brown PH 《Molecular endocrinology (Baltimore, Md.)》2005,19(2):362-378
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